ChemicalBook > CAS DataBase List > (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

Product Name
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
CAS No.
42399-49-5
Chemical Name
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Synonyms
HYDROXY LACTAM;(2S,3S)-DHMB;96.0%(LC&DiltiazeM IMpurity E;(2S) -cis-hydroxy lactam;CIS(+) HYDROXY DILTIAZEM;Diltiazem Hydrochloride Impurity E;(2S,3S)-3-Hydroxy-2-(4-methoxypheny;Diltiazem Hydrochloride EP Impurity E;Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem
CBNumber
CB2319542
Molecular Formula
C16H15NO3S
Formula Weight
301.36
MOL File
42399-49-5.mol
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(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Property

Melting point:
203-206 °C(lit.)
alpha 
112 º (c=0.5 in MeOH)
Boiling point:
545.4±50.0 °C(Predicted)
Density 
1.2458 (rough estimate)
refractive index 
114 ° (C=0.5, MeOH)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
pka
12.37±0.40(Predicted)
form 
Solid
color 
Off-White
InChIKey
LHBHZALHFIQJGJ-CABCVRRESA-N
CAS DataBase Reference
42399-49-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3661
Product name
(2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Purity
>96.0%(HPLC)(N)
Packaging
5g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
D3661
Product name
(2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
Purity
>96.0%(HPLC)(N)
Packaging
25g
Price
$111
Updated
2024/03/01
TRC
Product number
D288450
Product name
Des[3-Acetyl-5-(2-dimethylamino)ethyl]Diltiazem
Packaging
50mg
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21106
Product name
Des[3-acetyl-5-(2-dimethylamino)ethyl] diltiazem
Packaging
50g
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD21106
Product name
Des[3-acetyl-5-(2-dimethylamino)ethyl] diltiazem
Packaging
25g
Price
$55
Updated
2021/12/16
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(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Chemical Properties,Usage,Production

Chemical Properties

white to slightly beige powder

Uses

A key intermediate for Diltiazem (D460620) synthesis.

(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Suppliers

Americas 1 Belgium 1 Canada 1 China 139 Europe 3 Germany 2 India 30 Italy 1 Japan 2 Switzerland 2 United Kingdom 3 United States 18 Global 203
Acros Organics (Part of Thermo Fisher Scientific )
Tel
--
Fax
--
Email
fo@acros.com
Country
Belgium
ProdList
3824
Advantage
58
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View Lastest Price from (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 42399-49-5
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2024-11-11
Shaanxi Dideu New Materials Co. Ltd
Product
Hydroxy Lactam 42399-49-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100000KGS
Release date
2024-11-13
Dideu Industries Group Limited
Product
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 42399-49-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28

42399-49-5, (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-oneRelated Search:

CHLOROPHOSPHONAZO III Diltiazem Impurity 3 (2S,3S)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one 1-oxide N-DESMETHYLDILTIAZEM, HYDROCHLORIDE DESACETYL DILTIAZEM HCL Diltiazem EP Impurity B Diltiazem EP Impurity C Glycolic acid Hydroxy silicone oil 2-Phenylphenol Triphenylphosphine Hydroxyapatite 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Methoxyammonium chloride Camptothecin Series--10-hydroxycamptothecin Phenylacetone (+)-5-[2-(Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester) (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one

  • HYDROXY LACTAM
  • (2S-CIS)-(+)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE
  • (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one ,99%
  • DiltiazeM IMpurity E
  • 3-hydroxy-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
  • (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3-dihydrobenzo[b][1,4]thiazepin-4(5H)-one
  • (2<i>S</i>,3<i>S</i>)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5<i>H</i>)-one
  • Des[3-Acetyl-5-(2-dimethylamino)ethyl] Diltiazem
  • (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one(Dilthiazem hydrochloride)
  • 3-hydroxy-2-(4-methoxyphenyl)-3,5-dihydro-2H-1,5-benzothiazepin-4-one
  • 5-benzothiazepin-4(5h)-one,2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-(2s-c
  • CIS-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-4(5H)-ONE
  • (2S-CIS)-(+)-DIHYDRO-3-OH-2-(4-MEO-PH)-1 ,5-BENZOTHIAZEPIN-4(5H)-ONE, 98%
  • (2S,3S)-(+)-3-Hydroxy-2-(4'-Methoxyphenyl)-2.3-Dihydro-1,5-Benzothiazepin-4(5H)-One[Cis-(+)-HydroxyLactam]
  • 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S-cis)
  • (2S-CIS)-2,3-DIHYDRO-3-HYDROXY-2-(4-METHOXYPHENYL)-1,5-BENZOTHIAZEPIN-
  • (2S)-cis-(+)-2， 3-Dihydro-3-hydroxy-2- (4-methoxyphenyl)-1，5-benzothiazepin- 4(5H)-one (cis-Lactam)
  • (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • (2S)-2,3-Dihydro-3β-hydroxy-2β-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • (2S)-2β-(4-Methoxyphenyl)-3β-hydroxy-2,3,4,5-tetrahydro-1,5-benzothiazepine-4-one
  • (2S,3S)-DHMB
  • (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one,98%
  • (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one&gt
  • (2S,3S)-3-Hydroxy-2-(4-methoxypheny
  • 96.0%(LC&amp
  • 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-, (2S,3S)-
  • (2S,3S)-3-hydroxy-2-(4-methoxyphenyl)-2,3,4,5-tet rahydro-1,5-benzothiazepin-4-one
  • (2S,3S)-3-HYDROXY-2-(4-METHOXYPHENYL)-2,3-DIHYDRO-1,5-BENZOTHIAZEPIN-
  • (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one USP/EP/BP
  • (2S-cis)-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzo...
  • (2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-b 42399-49-5
  • (2S) -cis-hydroxy lactam
  • Diltiazem Hydrochloride EP Impurity E
  • Diltiazem Hydrochloride Impurity E
  • CIS(+) HYDROXY DILTIAZEM
  • Diltiazem EP Impurity E (2S,3S)-3-Hydroxy-2-(4-methoxyphenyl)-2,3- dihydro-1,5-benzothiazepin-4(5H)-one
  • (2S,3S)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one, ≥ 96.0%
  • 42399-49-5
  • C16H15NO3S
  • Heterocyclic Building Blocks
  • Others
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Pharmaceutical Intermediates
  • Chiral Building Blocks
  • Heterocyclic Building Blocks
  • Others
  • Heterocycles series
  • INTERMEDIATESOFDILTIAZEM
  • API intermediates
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds