4-Hydroxy-4'-isopropoxydiphenylsulfone

Product Name: 4-Hydroxy-4'-isopropoxydiphenylsulfone
CAS No.: 95235-30-6
Chemical Name: 4-Hydroxy-4'-isopropoxydiphenylsulfone
Synonyms: BPS-monoP;UBA7;UBE2;D-8.;UBE1L;UBA1B;D8(HPS);MGC12713;WinCon-8;F-108(D-8)
CBNumber: CB2324449
Molecular Formula: C15H16O4S
Formula Weight: 292.35
MOL File: 95235-30-6.mol

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4-Hydroxy-4'-isopropoxydiphenylsulfone Property

Melting point:: 129 °C
Boiling point:: 478.8±30.0 °C(Predicted)
Density: 1.251±0.06 g/cm3(Predicted)
vapor pressure: 0Pa at 27℃
storage temp.: Sealed in dry,Room Temperature
solubility: 0.891 in mg/100g standard fat at 20 ℃
form: powder to crystal
pka: 7.24±0.15(Predicted)
color: White to Almost white
Water Solubility: 19.7mg/L at 25℃
InChI: InChI=1S/C15H16O4S/c1-11(2)19-13-5-9-15(10-6-13)20(17,18)14-7-3-12(16)4-8-14/h3-11,16H,1-2H3
InChIKey: ZTILAOCGFRDHBH-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(S(C2=CC=C(OC(C)C)C=C2)(=O)=O)C=C1
LogP: 3.36 at 25℃
CAS DataBase Reference: 95235-30-6(CAS DataBase Reference)
EPA Substance Registry System: Phenol, 4-[[4-(1-methylethoxy)phenyl]sulfonyl]- (95235-30-6)

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Safety

Hazard Codes: N
Risk Statements: 51/53
Safety Statements: 61
HS Code: 2930.90.2900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements: H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SAB5300007
Product name: Monoclonal Anti-UBA7 antibody produced in mouse
Purity: clone 5B10, ascites fluid
Packaging: 100μL
Price: $503
Updated: 2023/01/07

Sigma-Aldrich

Product number: SAB1307068
Product name: ANTI-UBA7(N-TERMINAL) antibody produced in rabbit
Purity: affinity isolated antibody, buffered aqueous solution
Packaging: 400μL
Price: $461
Updated: 2023/01/07

TCI Chemical

Product number: I1045
Product name: 4-[(4-Isopropoxyphenyl)sulfonyl]phenol
Packaging: 5G
Price: $59
Updated: 2024/03/01

TCI Chemical

Product number: I1045
Product name: 4-[(4-Isopropoxyphenyl)sulfonyl]phenol
Packaging: 25G
Price: $203
Updated: 2024/03/01

Usbiological

Product number: 134984
Product name: UBA7
Packaging: 50ug
Price: $539
Updated: 2021/12/16

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4-Hydroxy-4'-isopropoxydiphenylsulfone Chemical Properties,Usage,Production

Uses

For color developing dyes, various types of dye such as fluoran, phthalide, lactam, triphenylmethane, spiropyran and other types of leuco dyes can be used, but usable dyes are not limited to these only. Besides, these color developing dyes can be mixed in different combinations.

Flammability and Explosibility

Not classified

Safety

4-Hydroxy-4′-isopropoxydiphenylsulfone (BPSIP), a novel alternative to BPA, is frequently detected in breast milk and the placental barrier system, suggesting that it may be transmitted from mother to offspring and increase the risk of exposure. In a study of the behavioral and neurobiological effects of early-life exposure to BPSIP (0.02, 0.1, and 0.5 mg/kg body weight/day) in mouse offspring, BPSIP exposure induced ASD-like behaviors in male and female pups, including increased anxiety-related behaviors and decreased spatial memory. A clear pattern of decreased social novelty was observed only in female offspring, accompanied by significant changes in antioxidant levels. In addition, decreased protein levels of complex IV (COX IV) in all tested populations suggest a significant impact on mitochondrial function, which may contribute to abnormal energy metabolism in autism. Changes in synaptic proteins, as evidenced by altered levels of synapsin 1 (SYN1) and postsynaptic density protein 95 (PSD95) in the cerebellum and hippocampus, support the idea of synaptic involvement. These findings suggest that BPSIP may induce sex-specific neurotoxic effects involving oxidative stress, energy production, and synaptic plasticity^[1].

Synthesis

30.3 g of bis(p-hydroxyphenyl)sulfone, 18.5 g of isopropylbromide, and 22.2 g of potassium carbonate as acid-binding agent were added to 200 ml of dimethylformamide, then stirred for 4 hours at about 120° C. and dimethylformamide was distilled off under reduced pressure. When this was accomplished, chloroform was added to the residue to extract crude 4-hydroxy-4'-isopropoxydiphenylsulfone. Then this crude compound was refined by using a silica gel column chromatography and 15.7 g of 4-hydroxy-4'-isopropoxydiphenylsulfone was obtained in white microfine crystals with a melting point of 129.0°~131.0° C.

References

[1] SHENGNAN ZHANG. Early-Life Exposure to 4-Hydroxy-4’-Isopropoxydiphenylsulfone Induces Behavioral Deficits Associated with Autism Spectrum Disorders in Mice.[J]. 环境科学与技术, 2024: 15984-15996. DOI:10.1021/acs.est.4c04760.

4-Hydroxy-4'-isopropoxydiphenylsulfone Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Hydroxy-4'-isopropoxydiphenylsulfone Suppliers

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View Lastest Price from 4-Hydroxy-4'-isopropoxydiphenylsulfone manufacturers

Jinan Finer Chemical Co., Ltd

Product: 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 99%
Supply Ability: 100mt/year
Release date: 2021-07-13

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-12

Hebei Weibang Biotechnology Co., Ltd

Product: 4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

95235-30-6, 4-Hydroxy-4'-isopropoxydiphenylsulfoneRelated Search:

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BPS-monoP

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4-Hydroxy-4'-isoprop

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Anti-UBE1L, C-Terminal antibody produced in rabbit

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4-ISOPROPOXYPHENYL-4'-HYDROXYPHENYL SULFONE

4-ISOPROPYLOXYPHENYL-4'-HYDROXYPHENYLSULFONE

D-8 DEVELOPER

D8(HPS)

4-hydroxy-4'-isopropoxydiphenylsulphone

4-hydroxy-4'-isopropoxydiphenylsulfone(D-8) developer

D8(HPS)4-ISOPROPYLOXYPHENYL-4'-HYDROXYPHENYLSULFONE

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D-8.

4-HYDROXY-4'' -CISOPROPOXYDIPHENYLSULFONE

4-(4-Isopropoxyphenylsulfonyl)phenol

Phenol,4-[[4-(1-methylethoxy)phenyl]sulfonyl]-

4-[[4-(1-Methylethoxy)phenyl]sulfonyl]phenol

4-Hydroxyphenyl 4-isopropoxyphenyl sulfone

4-Hydroxy-4-isopropoxydiphenylsulfone 99%

F-108(D-8)

4-(4-Isopropoxyp

4-HYDROXY-4''-ISOPROPOXYDIPHENYLSULFONE(D-8) DEVELOPER 99%

4,4,4&rsquo

DL-Homocystine-3,3,3&rsquo

WinCon-8

4-Hydroxy-4'-isopropoxydiphenylsulfone 95235-30-6

D8/4-hydroxy-4 '- isopropoxydiphenylsulfone/thermosensitive dye D-8

4-Hydroxy-4'-isopropoxydiphenylsulfone

4-Hydroxy-4'-isopropoxydiphenylsulfone(D8)

Thermal paper developer D8

4-Isopropyloxyphenyl-4'-Hydroxyphenylsulfone

4-[(4-Isopropoxyphenyl)sulfonyl]phenol （D8 )

95235-30-6

85235-80-6

95235-30-3

C15H16SO4