Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
- Product Name
- Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
- CAS No.
- 711085-63-1
- Chemical Name
- Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-
- Synonyms
- PNU 282987 free base;(R)-4-Chloro-N-(quinuclidin-3-yl)benzamide;4-chloro-N-[(3R)-quinuclidin-3-yl]benzamide;Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro-;N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide
- CBNumber
- CB23268809
- Molecular Formula
- C14H17ClN2O
- Formula Weight
- 264.75
- MOL File
- 711085-63-1.mol
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Property
- Boiling point:
- 431.5±30.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- solubility
- DMF: 10 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 5 mg/ml
- form
- A crystalline solid
- pka
- 13.86±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P2774
- Product name
- PNU-282987
- Packaging
- 10MG
- Price
- $108
- Updated
- 2025/07/31
- Product number
- P2774
- Product name
- PNU-282987
- Packaging
- 50MG
- Price
- $323
- Updated
- 2025/07/31
- Product number
- 17424
- Product name
- PNU 282987
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $45
- Updated
- 2024/03/01
- Product number
- 17424
- Product name
- PNU 282987
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 17424
- Product name
- PNU 282987
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Chemical Properties,Usage,Production
Uses
PNU-282987 is a highly selective α7 nicotinic acetylcholine receptor agonist (1,2). PNU-282,987 has been utilized to generate retinal neurons in the absence of retinal injury or exogenous growth factors in rat (1). PNU-282,987 has the potential to reverse vision loss due to neurodegenerative disease or aging.
Definition
ChEBI: N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-4-chlorobenzamide is a carbonyl compound and an organohalogen compound.
in vivo
PNU-282987 (free base) (Compound C7) (i.v.; 1, 3 mg/kg) leads to a reversal of the gating deficit[1].
PNU-282987 (30 μM) evokes currents in rat hippocampal neurons in a concentration-dependent and MLA blockable manner[1].
| Animal Model: | Rats[1] |
| Dosage: | 1, 3 mg/kg |
| Administration: | i.v. |
| Result: | Significantly reversed amphetamine-induced gating deficit. |
IC 50
5-HT3 Receptor
storage
Store at RT
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Preparation Products And Raw materials
Raw materials
Preparation Products
Benzamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-4-chloro- Suppliers
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