ChemicalBook > CAS DataBase List > L-Cysteine methyl ester hydrochloride

L-Cysteine methyl ester hydrochloride

Product Name
L-Cysteine methyl ester hydrochloride
CAS No.
18598-63-5
Chemical Name
L-Cysteine methyl ester hydrochloride
Synonyms
H-Cys-Ome;Methyl L-Cysteinate Hydrochloride;(R)-Cysteine Methyl Ester Hydrochloride;actiol;l.j.48;zeotin;acdrile;pectite;visclair;M-Cysten
CBNumber
CB2327369
Molecular Formula
C4H10ClNO2S
Formula Weight
171.65
MOL File
18598-63-5.mol
More
Less

L-Cysteine methyl ester hydrochloride Property

Melting point:
142 °C (dec.)(lit.)
alpha 
-2.25 º (c=5, 1 N HCl)
Density 
1.232 (estimate)
FEMA 
4781 | L-CYSTEINE METHYL ESTER HYDROCHLORIDE
refractive index 
-2.5 ° (C=20, MeOH)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol, Water (Slightly)
form 
Crystalline Powder
color 
White
biological source
synthetic
optical activity
[α]20/D 1.8°, c = 10 in methanol
Water Solubility 
Soluble in water
Merck 
13,5809
BRN 
3685824
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
WHOHXJZQBJXAKL-DFWYDOINSA-N
CAS DataBase Reference
18598-63-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-37/39
WGK Germany 
2
RTECS 
HA2460000
F 
1-10
HS Code 
29309090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H303May be harmfulif swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
410209
Product name
L-Cysteine methyl ester hydrochloride
Purity
98%
Packaging
5g
Price
$53.1
Updated
2025/07/31
Sigma-Aldrich
Product number
410209
Product name
L-Cysteine methyl ester hydrochloride
Purity
98%
Packaging
25g
Price
$78.1
Updated
2025/07/31
TCI Chemical
Product number
C0577
Product name
L-Cysteine Methyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
5g
Price
$17
Updated
2023/06/20
TCI Chemical
Product number
C0577
Product name
L-Cysteine Methyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
25g
Price
$32
Updated
2022/04/27
TCI Chemical
Product number
C0577
Product name
L-Cysteine Methyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
500g
Price
$273
Updated
2022/04/27
More
Less

L-Cysteine methyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

A mucolytic. An effective drug for the treatment of liver failure. Shown to effectively inhibit the binding of ethynylestradiol metabolites to protein and nucleic acids.

Uses

Mucolytic agent

Uses

L-Cysteine methyl ester hydrochloride is a biochemical shown to inhibit binding of ethynylestradiol metabolites to protein and nucleic acids. It used in the synthesis of peptides, Preparation of thiazolidine-4-carboxylates with carbonyl compounds.

Definition

ChEBI: Mecysteine hydrochloride is an alpha-amino acid ester.

Preparation

L-Cysteine methyl ester hydrochloride is prepared by esterification of L-cysteine hydrochloride monohydrate with methanol in the presence of hydrogen chloride.

reaction suitability

reaction type: solution phase peptide synthesis

Trade name

Acthiol (Joullié, France), Actiol (Lirca, Italy), Visclair (Sinclair, UK), Aslos-C (Nissin, J), Epectan (Seiko, Japan), Moltanine (Tohok.-Tokyo Tanabe, Japan), Radcol (Nippon Universal, Japan), Sekinin (Tokyo Hosei, Japan).

Synthesis

67-56-1

52-89-1

18598-63-5

3 mL of sulfoxide chloride (SOCl2) was slowly added dropwise to 35 mL of methanol under nitrogen protection in an ice bath. Subsequently, the reaction mixture was stirred at room temperature for 1 hour. After that, 1 g of L-cysteine hydrochloride monohydrate (Cys-HCl-H2O) was added to the above solution in batches. The reaction was continued with the mixed solution at room temperature for 3 hours and then heated to reflux for 1 hour. Upon completion of the reaction, the volatile components and solvent were removed by distillation under reduced pressure, and the resulting residue was recrystallized using a solvent mixture of methanol-dichloromethane (CH3OH-CH2Cl2) to give 0.84 g of the white solid product L-cysteine methyl ester hydrochloride in 85.9% yield. The product was analyzed by infrared spectroscopy (IR, KBr press) showing characteristic absorption peaks: 3040.4 cm-1 (strong, NH2 stretching vibration), 1709.7 cm-1 (strong, C=O stretching vibration), 2580 cm-1 (weak, SH stretching vibration). The nuclear magnetic resonance hydrogen spectrum (1H NMR, D2O as solvent, TMS as internal standard) data were as follows: δ 4.453 (t, 1H, CH, J = 5.2 Hz), 3.871 (s, 3H, CH3), 3.164 (t, 2H, CH2, J = 6.4 Hz). Elemental analysis results: Calculated values (C4H10NO2SCCl): C, 27.99%; H, 5.87%; N, 8.16%. Measured values: C, 28.11%; H, 6.01%; N, 8.08%.

References

[1] European Journal of Medicinal Chemistry, 2014, vol. 74, p. 199 - 215
[2] Journal of Organic Chemistry, 2013, vol. 78, # 9, p. 4270 - 4277
[3] Tetrahedron Asymmetry, 2000, vol. 11, # 21, p. 4255 - 4261
[4] Journal of the American Chemical Society, 2008, vol. 130, # 15, p. 5052 - 5053
[5] European Journal of Medicinal Chemistry, 2012, vol. 55, p. 176 - 187,12

L-Cysteine methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

L-Cysteine methyl ester hydrochloride Suppliers

Americas 1 Belgium 1 Canada 1 China 305 Europe 4 Germany 4 India 8 Japan 7 Romania 1 Slovakia 1 South Korea 1 Switzerland 5 United Kingdom 10 United States 47 Global 396
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19654
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Abblis Chemicals LLC
Tel
--
Fax
--
Email
info@abblis.com
Country
United States
ProdList
1272
Advantage
0
Wonda Science
Tel
--
Fax
--
Email
wonda@wondascience.com
Country
United States
ProdList
2192
Advantage
50
Scandinavian Formulas
Tel
--
Fax
--
Email
mikep@scandinavianformulas.com
Country
United States
ProdList
1550
Advantage
58
Sarchem Laboratories, Inc.
Tel
--
Fax
--
Email
info@sarchemlabs.com
Country
United States
ProdList
736
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Sarchem Laboratories, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
349
Advantage
58
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
AAPPTEC
Tel
--
Fax
--
Email
info@aapptec.com
Country
United States
ProdList
533
Advantage
0
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Pure Chemistry Scientific Inc
Tel
--
Fax
--
Email
sales@purechems.com
Country
United States
ProdList
2321
Advantage
50
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Chem-Impex International, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6730
Advantage
64
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
NetQem
Tel
--
Fax
--
Email
sales@netqem.us
Country
United States
ProdList
1641
Advantage
38
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Aroz Technologies, LLC.
Tel
--
Fax
--
Email
sales@aroztech.com
Country
United States
ProdList
1877
Advantage
30
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
MP Biomedicals, Inc.
Tel
--
Fax
--
Country
United States
ProdList
6561
Advantage
81
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
ECA International Corporation
Tel
--
Fax
--
Email
services@ecacorporation.com
Country
United States
ProdList
1062
Advantage
52
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Scandinavian Formulas, Inc.
Tel
--
Fax
--
Email
info@scandinavianformulas.com
Country
United States
ProdList
1447
Advantage
55
More
Less

View Lastest Price from L-Cysteine methyl ester hydrochloride manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
L-Cysteine methyl ester hydrochloride 18598-63-5
Price
US $1.00-4.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
L-Cysteine methyl ester hydrochloride 18598-63-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-26
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-L-Cys-OMe.HCl 18598-63-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-24

18598-63-5, L-Cysteine methyl ester hydrochlorideRelated Search:

L-Alanine methyl ester hydrochloride L-Cysteine Methyl acrylate Kresoxim-methyl L-Cysteine ethyl ester hydrochloride DL-Homocysteine N-Acetyl-L-cysteine Bensulfuron methyl Methylparaben Topotecan hydrochloride L-Cystine S-Cbz-L-cysteine H-CYS(Z)-OH HCL Thiophanate-methyl Methyl Methyl bromide Ethyl L-thiazolidine-4-carboxylate hydrochloride D-Cysteine methyl ester hydrochloride

  • L-Cysteine Methyl ester hydrochloride 98%
  • L-Cysteine methyl ester hydrochloride(Acdrile)
  • L-Cys-OMe·HCl
  • L-Cysteine methyl ester hydrochloride≥ 98.5% (Titration)
  • MECYSTEINE HYDROCHLORIDE
  • methyl cysteine hydrochloride
  • H-CYS-OME HCL
  • H-CYS(ME)OH HYDROCHLORIDE
  • L-CYSTEINE METHYL ESTER HYDROCHLORIDE
  • L-CYSTEINE METHYL ESTER MONOHYDROCHLORIDE
  • L-CYSTEIN METHYL ESTER HYDROCHLORIDE
  • acdrile
  • actiol
  • l.j.48
  • methylester,hydrochloride,l-cystein
  • pectite
  • visclair
  • zeotin
  • Methyl α-aMino-β-Mercaptopropionate hydrochloride
  • Methyl β-Mercaptoalanine hydrochloride
  • L-Cysteine Methyl ester hydrochloride, 98% 25GR
  • L-Cysteine Methyl ester hydrochloride, 98% 5GR
  • (R)-Cysteine Methyl Ester Hydrochloride
  • Methyl (R)-2-AMino-3-Mercaptopropanoate Hydrochloride
  • Methyl L-Cysteinate Hydrochloride
  • NSC 161611
  • (R)-Methyl 2-aMino-3-Mercaptopropanoate hydrochloride
  • L-CYSTEINE METHYL ESTER HYDROCHLORIDECRY STALLINE
  • L-CYSTEINE METHYL ESTER HYDROCHLORIDE, 9 8%
  • Mecysteine HCL
  • CYS-OME.HCL
  • L-Cysteine Methyl Ester HCl
  • L-Cystein methyl ester HCl
  • H-CYS(ME)-OH . HCL
  • [(2R)-3-mercapto-1-methoxy-1-oxopropan-2-yl]ammonium
  • Methyl cysteinate hydrochloride
  • Cysteine methyl·hydrochloride
  • L-Cyseinemethyl hydrochloride
  • L-Methylcyseine hydrochloride
  • M-Cysten
  • Methyl L-cysteine hydrochloride
  • L(-)-Cysteine Mehtyl Ester Hydrochloride
  • L-Cysteine methyl ester hydrochloride(Cys-Ome·HCl) ,98%
  • L-Cysteine methyl es
  • H-Cys-Ome
  • methyl (2R)-2-amino-3-sulfanylpropanoate,hydrochloride
  • L-Cysteine Methyl Ester Hydrochloride &gt
  • (R)-METHYL 2-AMINO-3-MERCAPTOPROPANOATE HCL
  • -Cysteine methyL
  • L-Cysteine methyl ester hydrochloride USP/EP/BP
  • L-Cysteine methyl ester hydrochloride,0.98
  • H-L-Cys-OMe.HCl
  • L-Cysteine, methyl ester, hydrochloride (9CI)
  • L-Cysteine methyl ester hydrochloride, 10 mM in DMSO
  • <sc>L</sc>-Cysteine methyl ester hydrochloride
  • 18598-63-5
  • 18698-63-5
  • C4H9NO2SHCl