3-Chloro-5-(trifluoromethyl)pyridin-2-amine
- Product Name
- 3-Chloro-5-(trifluoromethyl)pyridin-2-amine
- CAS No.
- 79456-26-1
- Chemical Name
- 3-Chloro-5-(trifluoromethyl)pyridin-2-amine
- Synonyms
- ACTP;5-ACTF;2,3,5-actf;TIMTEC-BB SBB003584;3-Chloro-5-(trifluor;LABOTEST-BB LT00012608;2-Amino-3-Chloro-5-Trifluorome;2-Amino-3-chloro-5-trifluoropyridine;2-Amino-3-chloro-5-(trifluoromethyl);2-AMINO-3-CHLORO-5-TRIFLUOROMETHYLPYRIDI
- CBNumber
- CB2331315
- Molecular Formula
- C6H4ClF3N2
- Formula Weight
- 196.56
- MOL File
- 79456-26-1.mol
3-Chloro-5-(trifluoromethyl)pyridin-2-amine Property
- Melting point:
- 86-90 °C (lit.)
- Boiling point:
- 205°C
- Density
- 1.4650 (estimate)
- vapor pressure
- 40.8Pa at 24.85℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 1.79±0.49(Predicted)
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- 622mg/L at 25℃
- InChI
- InChI=1S/C6H4ClF3N2/c7-4-1-3(6(8,9)10)2-12-5(4)11/h1-2H,(H2,11,12)
- InChIKey
- WXNPZQIRDCDLJD-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(C(F)(F)F)C=C1Cl
- LogP
- 2.59 at 20℃
- CAS DataBase Reference
- 79456-26-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-52/53-36/37/38-20/21/22
- Safety Statements
- 61-36/37/39-26-22
- WGK Germany
- 2
- HazardClass
- IRRITANT
- HS Code
- 29339900
N-Bromosuccinimide Price
- Product number
- 366080
- Product name
- 2-Amino-3-chloro-5-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 25g
- Price
- $44.9
- Updated
- 2023/06/20
- Product number
- A1157
- Product name
- 2-Amino-3-chloro-5-trifluoromethylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- A1157
- Product name
- 2-Amino-3-chloro-5-trifluoromethylpyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- A596070
- Product name
- 2-Amino-3-chloro-5-trifluoromethylpyridine
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H30-7-35
- Product name
- 2-Amino-3-chloro-5-(trifluoromethyl)pyridine
- Purity
- 97%
- Packaging
- 100g
- Price
- $55
- Updated
- 2021/12/16
3-Chloro-5-(trifluoromethyl)pyridin-2-amine Chemical Properties,Usage,Production
Chemical Properties
Light yellow Cryst
Uses
2-?Amino-?3-?chloro-?5-?trifluoromethylpyrid?ine acts as a reactant in the synthesis of novel imidazo[1,2-a]pyridine-coumarin hybrid molecules as inhibitors of NS5B in potential treatment of Hepititis C.
Definition
ChEBI: 3-Chloro-5-(trifluoromethyl)pyridin-2-amine is an aminopyridine.
Synthesis
69045-84-7
79456-26-1
Example 1: General procedure for the synthesis of 2-amino-3-chloro-5-trifluoromethylpyridine from 2,3-dichloro-5-trifluoromethylpyridine 1. Ammonolysis reaction: 2,3-dichloro-5-trifluoromethylpyridine (26.75 g, 0.125 mol) and water (25 ml) were added to an autoclave. After sealing, liquid ammonia (45 g, 2.85 mol) was added through a pressure bottle. The reaction mixture was heated to 80 °C and maintained for 9 h at 18-22 bar pressure. After cooling to room temperature, the intermediate 2-amino-3-chloro-5-trifluoromethylpyridine was obtained by filtration, washed with water and dried (22 g, 90% yield). 2. Condensation reaction: the above intermediate was dissolved in acetonitrile (230 ml), cooled to 5 ℃ and added solid KOH (12 g, 0.22 mol). A solution of 2,4-dichloro-3,5-dinitro-5-trifluoromethylbenzene (25 g, 0.08 mol) in acetonitrile (230 ml) was added slowly over 15 min under continuous cooling conditions. The reaction was gradually warmed up to 25°C for 4 hours and subsequently warmed up to 40°C for 2 hours. 3. Post-treatment: The reaction mixture was poured into water (1500 ml) and the pH was adjusted to about 4 with a 4N aqueous hydrochloric acid solution, followed by extraction with isopropyl acetate (2 x 750 ml). The organic phases were combined and concentrated to dryness to give the crude fludioxamine (43 g, 70% yield, 60% purity). The target product can be further purified by recrystallization.
References
[1] Patent: WO2014/198278, 2014, A1. Location in patent: Page/Page column 9; 17
[2] Heterocycles, 1984, vol. 22, # 1, p. 117 - 124
[3] Patent: US4349681, 1982, A
3-Chloro-5-(trifluoromethyl)pyridin-2-amine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Chloro-5-(trifluoromethyl)pyridin-2-amine Suppliers
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View Lastest Price from 3-Chloro-5-(trifluoromethyl)pyridin-2-amine manufacturers
- Product
- Pal-GHK 79456-26-1
- Price
- US $1.00-100.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 300KG
- Release date
- 2025-09-03
- Product
- 2-Amino-3-chloro-5-(trifluoromethyl)pyridine 79456-26-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 25KG
- Purity
- Purity: 99%
- Supply Ability
- 1000tons
- Release date
- 2025-07-20
- Product
- 3-Chloro-5-(trifluoromethyl)pyridin-2-amine 79456-26-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-25