ChemicalBook > CAS DataBase List > ROC-325

ROC-325

Product Name
ROC-325
CAS No.
1859141-26-6
Chemical Name
ROC-325
Synonyms
ROC-325;ROC325;ROC 325;ROC-325 ，S8527;ROC-325, 10 mM in DMSO;1-((2-((2-((7-Chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one;9H-Thioxanthen-9-one, 1-[[2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]methylamino]ethyl]amino]-4-methyl-;Apoptosis,anticancer,inhibit,Autophagosomes,cathepsin-D,lysosomes,ROC 325,ROC-325,ROC325,oral,Autophagy,Inhibitor
CBNumber
CB23339912
Molecular Formula
C28H27ClN4OS
Formula Weight
503.06
MOL File
1859141-26-6.mol
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ROC-325 Property

Boiling point:
726.0±60.0 °C(Predicted)
Density 
1.344±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Chloroform: 10 mg/ml; DMF: slightly soluble; DMSO: slightly soluble; Ethanol: slightly soluble
form 
A solid
pka
8.36±0.50(Predicted)
color 
Light yellow to orange
InChIKey
HXUYKEGAEIYPKY-UHFFFAOYSA-N
SMILES
C1(=O)C2=C(C=CC=C2)SC2=C1C(NCCN(CCNC1=C3C(=NC=C1)C=C(Cl)C=C3)C)=CC=C2C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
R639505
Product name
ROC325
Packaging
2.5mg
Price
$180
Updated
2021/12/16
Ambeed
Product number
A461073
Product name
ROC-325
Purity
98+%
Packaging
25mg
Price
$200
Updated
2021/12/16
Ambeed
Product number
A461073
Product name
ROC-325
Purity
98+%
Packaging
50mg
Price
$320
Updated
2021/12/16
Ambeed
Product number
A461073
Product name
ROC-325
Purity
98+%
Packaging
100mg
Price
$485
Updated
2021/12/16
DC Chemicals
Product number
DC10097
Product name
ROC-325
Purity
>98%
Packaging
250mg
Price
$950
Updated
2021/12/16
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ROC-325 Chemical Properties,Usage,Production

Uses

ROC 325, is a novel inhibitor of autophagy. It triggers an increase in cathepsin D (CTSD) levels.

in vivo

Oral administration of ROC-325 (25 mg/kg, 40 mg/kg, 50 mg/kg,) to mice bearing 786-0 RCC xenografts is well tolerated, significantly more effective at inhibiting tumor progression than Hydroxychloroquine, and inhibits autophagy in vivo[1].

ROC-325 Preparation Products And Raw materials

Raw materials

Preparation Products

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ROC-325 Suppliers

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1859141-26-6, ROC-325Related Search:

Ro 3306 Bisindoylmaleimide X RO495 3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)-N-(2-hydroxyethoxy)-5-((3-oxoMorpholino)Methyl)benzaMide 3,4-dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide RO2959 Hydrochloride (S)-2-(4-(2-chlorophenoxy)-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(1-((S)-2,3-dihydroxypropyl)-1H-pyrazol-3-yl)-4-methylpentanamide

  • ROC-325
  • ROC325;ROC 325
  • 9H-Thioxanthen-9-one, 1-[[2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]methylamino]ethyl]amino]-4-methyl-
  • 1-((2-((2-((7-Chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one
  • Apoptosis,anticancer,inhibit,Autophagosomes,cathepsin-D,lysosomes,ROC 325,ROC-325,ROC325,oral,Autophagy,Inhibitor
  • ROC-325, 10 mM in DMSO
  • ROC-325 ，S8527
  • 1859141-26-6