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RESCINNAMINE

Product Name
RESCINNAMINE
CAS No.
24815-24-5
Chemical Name
RESCINNAMINE
Synonyms
Rozex;Apolon;Rescin;Tuareg;ANAPREL;Anapral;Cartric;Moderil;Resipal;Apoterin
CBNumber
CB2344278
Molecular Formula
C35H42N2O9
Formula Weight
634.73
MOL File
24815-24-5.mol
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RESCINNAMINE Property

Melting point:
238-239°C
alpha 
D24 -97° (c = 1 in chloroform)
Boiling point:
669.26°C (rough estimate)
Density 
1.2161 (rough estimate)
refractive index 
1.5300 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
pKa 6.4 (Uncertain)
color 
Pale Beige to Pale Brown
Stability:
Stable, but darkens slowly in light. Incompatible with strong oxidizing agents.
EPA Substance Registry System
Rescinnamine (24815-24-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
25-20/21/22
Safety Statements 
22-45-36
RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
24815-24-5(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
R144720
Product name
Rescinnamine
Packaging
10mg
Price
$765
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61500
Product name
Cartric
Packaging
10mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61500
Product name
Cartric
Packaging
25mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61500
Product name
Cartric
Packaging
50mg
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC61500
Product name
Cartric
Packaging
100mg
Price
$200
Updated
2021/12/16
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RESCINNAMINE Chemical Properties,Usage,Production

Description

This Rauwolfia alkaloid is found in the barks of R. serpentina and R. vomitora and was originally given the name Reserpinine, this being altered to avoid confusion with another alkaloid of the same name (q.v.). The base has [α]17D - 99.2° (c 1.3, CHCI3). From chemical degradation and spectroscopic analysis, the structure has been established as the 3:4: 5-trimethoxycinnamoyl ester of reserpic acid.

Chemical Properties

white to cream powder

Uses

Rescinnamine occurs in the roots of a num ber of Rauwolfia species. Therapeutically, itis used as an antihypertensive agent.

Uses

Rescinnamine is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.

Definition

ChEBI: Rescinnamine is a methyl ester, an organic heteropentacyclic compound and an indole alkaloid. It has a role as an antihypertensive agent. It derives from a hydride of a yohimban.

brand name

Moderil (Pfizer).

General Description

Odorless white to cream colored crystalline powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

The neat material darkens slowly on exposure to light. In solution this occurs more rapidly. .

Health Hazard

The pharmacological properties of rescinnamine are similar to those of reserpine, butthe side effects are low. It acts as a sedativeand hypotensive. A dose of 0.25 mg/day mayproduce the effect of sleepiness in humans.Excessive doses may produce depression,nightmare, nausea, diarrhea, and hypotension.
LD50 value, oral (rats): 1000 mg/kg
The carcinogenicity of rescinnamine inanimals or humans is unknown.

Fire Hazard

Flash point data for RESCINNAMINE are not available. RESCINNAMINE is probably combustible.

Purification Methods

Crystallise it from *benzene, MeOH or aqueous Me2CO. The hydrochloride has m 232o(dec) (from MeOH) and [] D -74o (MeOH). It is an antihypertensive. [Klohs et al. J Am Chem Soc 77 2241 1955, Beilstein 25 III/IV 1323.]

References

Haack e tal., Naturwiss., 41, 214 (1954)
Klohs, Draper, Keller.,J. Amer. Chem. Soc., 77,2241 (1955)
Kidd., Chem. & Ind., 1481 (1955)
Popelak, Lettenbauer., Arch. Pharm., 296,261 (1963)

RESCINNAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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24815-24-5, RESCINNAMINERelated Search:

(R)-(-)-1-METHOXY-2-PROPANOL 2-Nonanamine N-BUTYL CINNAMATE METHYL 3,4,5-TRIMETHOXYCINNAMATE 2-METHOXY-1-BUTANOL RESCINNAMINE 2-AMINOHEPTANE 1,6-DIMETHOXYHEXANE (1-Methyl-piperidin-4-yl)-acetaldehyde 3-(2-Aminoethyl)-6-methoxyindole Piperidine DL-3-Methylvaleric acid (1R,2R)-TRANS-1,2-CYCLOHEXANEDIOL N-Methylpiperidine 2-Methylpiperidine Caprylic acid methyl ester 3-METHYLPYRROLE 3-METHOXYCINNAMIC ACID

  • Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-[[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]oxy]-, methyl ester, (3β,16β,17α,18β,20α)-
  • METHYL RESERPATE-3,4,5-TRIMETHOXY CINNAMIC ACID ESTER
  • ANAPREL
  • 3,4,5-TRIMETHOXYCINNAMOYLRESERPATE
  • 17alpha-dimethoxy-18beta-((1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)oxy)-1
  • 3,4,5-Trimethoxycinnamic acid, methyl reserpate
  • 3,4,5-Trimethoxycinnamoyl methyl reserpate
  • 3,4,5-trimethoxycinnamoylmethylreserpate
  • 3,4,5-Trimethylcinnamic acid, ester with methyl reserpate
  • 3,4,5-trimethylcinnamicacid,esterwithmethylreserpate
  • 3,4,5-Trimethylcinnamoyl methyl reserpate
  • 3,4,5-trimethylcinnamoylmethylreserpate
  • 3beta,20alpha-Yohimban-16beta-carboxylic acid, 18beta-hydroxy-11,17alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxycinnamate (ester)
  • 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 18-beta-hydroxy-11,17-alpha-dimethoxy-,methyl ester, 3,4,5-trimethoxycinnamate
  • 3beta,20alpha-yohimban-16beta-carboxylicacid,18beta-hydroxy-11,17alpha-dimeth
  • 3beta,20alpha-yohimban-16beta-carboxylicacidmethylester
  • Anapral
  • Apolon
  • Apoterin
  • Apoterin S
  • Benz(g)indolo(2,3-a)quinolizine-1-carboxylic acid, 1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydro-3-hydroxy-2,11-dimethoxy-, methyl ester, 3,4,5-trimethoxycinnamate
  • Cartric
  • Cinamine
  • Cinatabs
  • Cinnaloid
  • Cinnasil
  • imethoxy-,methylester,3,4,5-trimethoxycinnamate(ester)
  • Methyl 11,17-dimethoxy-18-([(2E)-3-(3,4,5-trimethoxyphenyl)-2-propenoyl]oxy)yohimban-16-carboxylate
  • Methyl 18beta-hydroxy-11,17alpha-dimethoxy-3beta,20alpha-yohimban-16beta-carboxylate
  • Methyl 18-O-(3,4,5-trimethoxycinnamoyl)reserpate
  • Methyl trimethoxycinnamoylreserpate
  • methyl18-o-(3,4,5-trimethoxycinnamoyl)reserpate
  • methyl18-o-(3,4,5-trimethoxycinnamoylreserpate
  • methylester,3,4,5-trimethoxycinnamate(ester),(e)-oxy
  • methyltrimethoxycinnamoylreserpate
  • Moderil
  • Normorescina
  • Paresinan
  • Raupyrol
  • Raurescin
  • Raurescine
  • Recinnamine
  • Recitensina
  • Rescaloid
  • Rescamin
  • Rescidan
  • Rescin
  • Rescinnamin
  • Rescinpal
  • Rescisan
  • Rescitens
  • Resealoid
  • resepinine(c35alkaloid)
  • Reserpinene
  • Reserpinin
  • Reserpinine (C35 alkaloid)
  • reserpinine[c35alkaloid]
  • Resipal