ChemicalBook > CAS DataBase List > 4-METHOXY-2-METHYLPHENYLBORONIC ACID

4-METHOXY-2-METHYLPHENYLBORONIC ACID

Uses

Product Name: 4-METHOXY-2-METHYLPHENYLBORONIC ACID
CAS No.: 208399-66-0
Chemical Name: 4-METHOXY-2-METHYLPHENYLBORONIC ACID
Synonyms: 2-methyl-4-methoxyphenylboronic acid;AKOS BRN-0221;4-Methoxy-2-methyL;4-Methoxy-2-Methylphenylboroni;4-Methoxy-2-methylphebylboronic acid;4-METHOXY-2-METHYLPHENYLBORONIC ACID;(4-methoxy-2-methylphenyl)boronicaci;2-Methyl-4-methoxybenzeneboronic acid;4-METHOXY-2-METHYLBENZENEBORONIC ACID;B-(4-Methoxy-2-methylphenyl)boronic acid
CBNumber: CB2344430
Molecular Formula: C8H11BO3
Formula Weight: 165.98
MOL File: 208399-66-0.mol

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4-METHOXY-2-METHYLPHENYLBORONIC ACID Property

Melting point:: 169-174 °C (lit.)
Boiling point:: 327.1±52.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 9.03±0.58(Predicted)
form: Crystalline Solid
color: White
Water Solubility: Insoluble in water.
BRN: 8111222
InChI: InChI=1S/C8H11BO3/c1-6-5-7(12-2)3-4-8(6)9(10)11/h3-5,10-11H,1-2H3
InChIKey: AMSQNQJCBXQYEX-UHFFFAOYSA-N
SMILES: B(C1=CC=C(OC)C=C1C)(O)O
CAS DataBase Reference: 208399-66-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-37/39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29163990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 639370
Product name: 4-Methoxy-2-methylphenylboronic acid
Packaging: 1g
Price: $22.24
Updated: 2025/07/31

Sigma-Aldrich

Product number: 639370
Product name: 4-Methoxy-2-methylphenylboronic acid
Packaging: 5g
Price: $72.3
Updated: 2023/06/20

TCI Chemical

Product number: M2255
Product name: 4-Methoxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 1g
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: M2255
Product name: 4-Methoxy-2-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $180
Updated: 2025/07/31

TRC

Product number: M219153
Product name: 4-Methoxy-2-methylphenylboronic acid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

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4-METHOXY-2-METHYLPHENYLBORONIC ACID Chemical Properties,Usage,Production

Uses

4-Methoxy-2-Methylphenylboronic Acid is a useful research chemical.

Chemical Properties

White solid

Uses

Reactant for preparation of biologically active molecule preparation of hydroxyphenylnaphthols as 17?-hydroxysteroid dehydrogenase Type 2 inhibitors

Uses

suzuki reaction

Synthesis

5419-55-6

27060-75-9

208399-66-0

4-Methoxy-2-methylphenylboronic acid was synthesized as follows: 4-bromo-3-methylanisole (10 g, 0.050 mol) was used as starting material, and reacted with n-butyllithium (24 mL of 2.5 M hexane solution, 0.055 mol) under anhydrous and anaerobic conditions at a low temperature (-78°C) to generate the corresponding aryl lithium intermediate. Subsequently, triisopropyl borate (57.7 mL, 47.02 g, 0.25 mol) was added to the reaction system, slowly warmed to room temperature and stirred overnight. Upon completion of the reaction, the crude product was obtained by acidic hydrolysis treatment and purified to give 5.7 g of 4-methoxy-2-methylphenylboronic acid white solid in 69% yield. The product was characterized by mass spectrometry (ESI), m/z 313 (2M-H2O-H)-.

References

[1] Organic Letters, 2001, vol. 3, # 26, p. 4263 - 4265
[2] Patent: US2003/181519, 2003, A1

4-METHOXY-2-METHYLPHENYLBORONIC ACID Preparation Products And Raw materials

Raw materials

Tetrahydrofuran 2-Methylanisole Bromine Triisopropyl borate Acetic acid n-Butyllithium

Preparation Products

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View Lastest Price from 4-METHOXY-2-METHYLPHENYLBORONIC ACID manufacturers

Career Henan Chemical Co

Product: 4-METHOXY-2-METHYLPHENYLBORONIC ACID 208399-66-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg;5kg;100kg
Release date: 2019-07-04

208399-66-0, 4-METHOXY-2-METHYLPHENYLBORONIC ACIDRelated Search:

AKOS BRN-0221

4-METHOXY-2-METHYLBENZENEBORONIC ACID

4-METHOXY-2-METHYLPHENYLBORONIC ACID

2-methyl-4-methoxyphenylboronic acid

4-Methoxy-2-Methylphenylboronic Acid (contains varying aMounts of Anhydride)

4-Methoxy-2-Methylphenylboronic Acid&nbsp

4-Methoxy-2-methylphebylboronic acid

4-Methoxy-2-Methylphenylboroni

4-Methoxy-2-methylphenylboronic acid ,98%

4-Borono-3-methylanisole, 2-Borono-5-methoxytoluene

2-Methyl-4-methoxybenzeneboronic acid

B-(4-Methoxy-2-methylphenyl)boronic acid

4-Methoxy-2-methyL

Boronic acid, B-(4-methoxy-2-methylphenyl)-

(4-methoxy-2-methylphenyl)boronicaci

4-Methoxy-2-methylphenylboronic acid - [M4226]

208399-66-0

CH3OC6H3CH3BOH2

Organometallic Reagents

Boronic Acids

Boronic Acids and Derivatives

Aryl

Boronic acids

Boronic acid

Aryl

Boronic Acids

Boronic Acids and Derivatives

blocks

BoronicAcids