2-Methoxy-5-methylphenylboronic acid

Product Name: 2-Methoxy-5-methylphenylboronic acid
CAS No.: 127972-00-3
Chemical Name: 2-Methoxy-5-methylphenylboronic acid
Synonyms: AKOS BRN-0586;CHEMBRDG-BB 4008663;2-Methoxy-5-Methylphenylboroni;2-Methoxy-5-methylphenylboronic Aci;5-Methyl-2-methoxyphenylboronic acid;2-METHOXY-5-METHYLPHENYLBORONIC ACID;(2-Methoxy-5-methylphenyl)boranediol;5-METHOXY-2-METHYLPHENYL BORONIC ACID;(2-METHOXY-5-METHYLBENZENE)BORONIC ACID;2-Methoxy-5-methylphenylboronic acid >=95%
CBNumber: CB3742237
Molecular Formula: C8H11BO3
Formula Weight: 165.98
MOL File: 127972-00-3.mol

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2-Methoxy-5-methylphenylboronic acid Property

Melting point:: 92-97 °C (lit.)
Boiling point:: 342.0±52.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in methanol.
form: powder to crystal
pka: 8.65±0.58(Predicted)
color: White to Almost white
CAS DataBase Reference: 127972-00-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37/39-60-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29319090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 567507
Product name: 2-Methoxy-5-methylphenylboronic acid
Purity: ≥95%
Packaging: 1g
Price: $127
Updated: 2023/06/20

Sigma-Aldrich

Product number: 567507
Product name: 2-Methoxy-5-methylphenylboronic acid
Purity: ≥95%
Packaging: 5g
Price: $290
Updated: 2023/06/20

TCI Chemical

Product number: M2311
Product name: 2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 5g
Price: $322
Updated: 2025/07/31

TCI Chemical

Product number: M2311
Product name: 2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging: 25g
Price: $1160
Updated: 2025/07/31

TRC

Product number: M330788
Product name: 2-Methoxy-5-methylphenylboronic acid
Packaging: 10mg
Price: $45
Updated: 2021/12/16

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2-Methoxy-5-methylphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Reactant for:

Coupling reactions
Preparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants
Rh-catalyzed asymmetric arylation of aldehydes
Stereoselective hydroarylation reactions
Suzuki-Miyaura cross-coupling

Uses

suzuki reaction

Synthesis

121-43-7

22002-45-5

127972-00-3

To a solution of 2-bromo-1-methoxy-4-methylbenzene (1.39 g, 15 mmol) in tetrahydrofuran (THF) was slowly added n-butyllithium (15 mmol) dropwise under nitrogen protection and -78 °C. The solution was stirred for 1 h. The solution was then mixed with tetramethyl borate (100 mL). After maintaining -78 °C and stirring for 1 h, the solution was transferred to a solution of THF (100 mL) containing trimethyl borate (15 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Subsequently, the reaction mixture was poured into 3N hydrochloric acid (125 mL) and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellowish white solid product 2-methoxy-5-methylphenylboronic acid (2.2 g, 89% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 7.6 (s, 1H), 7.38 (d, J = 2.3 Hz, 1H), 7.19 (dd, J = 8.4 Hz, 2.3 Hz, 1H), 6.87 (d, J = 8.4 Hz, 1H), 3.78 (s, 3H), 2.2 (s, 3H).

References

[1] Patent: US2004/19190, 2004, A1. Location in patent: Page 24
[2] Patent: US5688808, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5688810, 1997, A
[5] Patent: US5693647, 1997, A

2-Methoxy-5-methylphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-5-methylphenylboronic acid Suppliers

Americas 1 China 115 Europe 1 France 2 Germany 9 India 4 Italy 1 Japan 2 Russia 2 Switzerland 1 United Kingdom 9 United States 37 Global 184

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View Lastest Price from 2-Methoxy-5-methylphenylboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Methoxy-5-methylphenylboronic acid 127972-00-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Methoxy-5-methylphenylboronic acid 127972-00-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 2-Methoxy-5-methylphenylboronic acid 127972-00-3
Price: US $2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customise
Release date: 2018-08-09

127972-00-3, 2-Methoxy-5-methylphenylboronic acidRelated Search:

3-(METHOXYMETHOXY)BENZALDEHYDE 4-Tolylboronic acid 4-Methoxyphenylboronic acid Anisole p-Anisaldehyde 4-Methoxybenzoic acid (4-METHOXYPHENYL)-BORANE Phenylboronic acid 3-Methoxyacetophenone (Trifluoromethoxy)benzene 4'-Methoxyacetophenone Ascoric Acid 3-BROMO-2-BUTOXY-5-METHYLPHENYLBORONIC & 3-BROMO-5-METHYL-2-PROPOXYPHENYLBORONIC& 2-ISOPROPOXY-5-METHYLPHENYLBORONIC ACID 5-METHYL-2-PROPOXYPHENYLBORONIC ACID 3-BROMO-2-ETHOXY-5-METHYLPHENYLBORONIC & 2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID

5-Methyl-2-methoxyphenylboronic acid

(2-methoxy-5-methylphenyl)boronic acid(SALTDATA: FREE)

2-Methoxy-5-Methylphenylboronic Acid (contains varying aMounts of Anhydride)

BORONICACID, (2-METHOXY-5-METHYLPHENYL)- (9CI)

2-Methoxy-5-methylphenylboronic acid >=95%

CHEMBRDG-BB 4008663

AKOS BRN-0586

5-METHOXY-2-METHYLPHENYL BORONIC ACID

2-METHOXY-5-METHYLPHENYLBORONIC ACID

(2-METHOXY-5-METHYLBENZENE)BORONIC ACID

2-Methoxy-5-Methylphenylboroni

2-METHOXY-5-METHYLPHENYLBORONIC ACID, 98+%

2-Methoxy-5-methylphenylboronic Aci

Boronic acid, B-(2-methoxy-5-methylphenyl)-

(2-Methoxy-5-methylphenyl)boranediol

127972-00-3

27972-00-3

C6H3CH3OCH3BOH2

BORONIC ACID

Organometallic Reagents

Aryl

Boronic Acids

Boronic Acids and Derivatives

Boronic Acids

Aryl

Organoborons

Boronic Acids

Boronic Acids and Derivatives

Substituted Boronic Acids

blocks

BoronicAcids

Heterocyclic Compounds

Alkoxy