ChemicalBook > CAS DataBase List > 2-Methoxy-5-methylphenylboronic acid

2-Methoxy-5-methylphenylboronic acid

Product Name
2-Methoxy-5-methylphenylboronic acid
CAS No.
127972-00-3
Chemical Name
2-Methoxy-5-methylphenylboronic acid
Synonyms
AKOS BRN-0586;CHEMBRDG-BB 4008663;2-Methoxy-5-Methylphenylboroni;2-Methoxy-5-methylphenylboronic Aci;5-Methyl-2-methoxyphenylboronic acid;2-METHOXY-5-METHYLPHENYLBORONIC ACID;(2-Methoxy-5-methylphenyl)boranediol;5-METHOXY-2-METHYLPHENYL BORONIC ACID;(2-METHOXY-5-METHYLBENZENE)BORONIC ACID;2-Methoxy-5-methylphenylboronic acid >=95%
CBNumber
CB3742237
Molecular Formula
C8H11BO3
Formula Weight
165.98
MOL File
127972-00-3.mol
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2-Methoxy-5-methylphenylboronic acid Property

Melting point:
92-97 °C (lit.)
Boiling point:
342.0±52.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Soluble in methanol.
form 
powder to crystal
pka
8.65±0.58(Predicted)
color 
White to Almost white
CAS DataBase Reference
127972-00-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-60-37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29319090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
567507
Product name
2-Methoxy-5-methylphenylboronic acid
Purity
≥95%
Packaging
1g
Price
$127
Updated
2023/06/20
Sigma-Aldrich
Product number
567507
Product name
2-Methoxy-5-methylphenylboronic acid
Purity
≥95%
Packaging
5g
Price
$290
Updated
2023/06/20
TCI Chemical
Product number
M2311
Product name
2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
5g
Price
$322
Updated
2025/07/31
TCI Chemical
Product number
M2311
Product name
2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride)
Packaging
25g
Price
$1160
Updated
2025/07/31
TRC
Product number
M330788
Product name
2-Methoxy-5-methylphenylboronic acid
Packaging
10mg
Price
$45
Updated
2021/12/16
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2-Methoxy-5-methylphenylboronic acid Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

Reactant for:

  • Coupling reactions
  • Preparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants
  • Rh-catalyzed asymmetric arylation of aldehydes
  • Stereoselective hydroarylation reactions
  • Suzuki-Miyaura cross-coupling

Uses

suzuki reaction

Synthesis

121-43-7

22002-45-5

127972-00-3

To a solution of 2-bromo-1-methoxy-4-methylbenzene (1.39 g, 15 mmol) in tetrahydrofuran (THF) was slowly added n-butyllithium (15 mmol) dropwise under nitrogen protection and -78 °C. The solution was stirred for 1 h. The solution was then mixed with tetramethyl borate (100 mL). After maintaining -78 °C and stirring for 1 h, the solution was transferred to a solution of THF (100 mL) containing trimethyl borate (15 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Subsequently, the reaction mixture was poured into 3N hydrochloric acid (125 mL) and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellowish white solid product 2-methoxy-5-methylphenylboronic acid (2.2 g, 89% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 7.6 (s, 1H), 7.38 (d, J = 2.3 Hz, 1H), 7.19 (dd, J = 8.4 Hz, 2.3 Hz, 1H), 6.87 (d, J = 8.4 Hz, 1H), 3.78 (s, 3H), 2.2 (s, 3H).

References

[1] Patent: US2004/19190, 2004, A1. Location in patent: Page 24
[2] Patent: US5688808, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5688810, 1997, A
[5] Patent: US5693647, 1997, A

2-Methoxy-5-methylphenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-5-methylphenylboronic acid Suppliers

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View Lastest Price from 2-Methoxy-5-methylphenylboronic acid manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Methoxy-5-methylphenylboronic acid 127972-00-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Methoxy-5-methylphenylboronic acid 127972-00-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Career Henan Chemical Co
Product
2-Methoxy-5-methylphenylboronic acid 127972-00-3
Price
US $2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
Customise
Release date
2018-08-09

127972-00-3, 2-Methoxy-5-methylphenylboronic acidRelated Search:

3-(METHOXYMETHOXY)BENZALDEHYDE 4-Tolylboronic acid 4-Methoxyphenylboronic acid Anisole p-Anisaldehyde 4-Methoxybenzoic acid (4-METHOXYPHENYL)-BORANE Phenylboronic acid 3-Methoxyacetophenone (Trifluoromethoxy)benzene 4'-Methoxyacetophenone Ascoric Acid 3-BROMO-2-BUTOXY-5-METHYLPHENYLBORONIC & 3-BROMO-5-METHYL-2-PROPOXYPHENYLBORONIC& 2-ISOPROPOXY-5-METHYLPHENYLBORONIC ACID 5-METHYL-2-PROPOXYPHENYLBORONIC ACID 3-BROMO-2-ETHOXY-5-METHYLPHENYLBORONIC & 2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID

  • 5-Methyl-2-methoxyphenylboronic acid
  • (2-methoxy-5-methylphenyl)boronic acid(SALTDATA: FREE)
  • 2-Methoxy-5-Methylphenylboronic Acid (contains varying aMounts of Anhydride)
  • BORONICACID, (2-METHOXY-5-METHYLPHENYL)- (9CI)
  • 2-Methoxy-5-methylphenylboronic acid >=95%
  • CHEMBRDG-BB 4008663
  • AKOS BRN-0586
  • 5-METHOXY-2-METHYLPHENYL BORONIC ACID
  • 2-METHOXY-5-METHYLPHENYLBORONIC ACID
  • (2-METHOXY-5-METHYLBENZENE)BORONIC ACID
  • 2-Methoxy-5-Methylphenylboroni
  • 2-METHOXY-5-METHYLPHENYLBORONIC ACID, 98+%
  • 2-Methoxy-5-methylphenylboronic Aci
  • Boronic acid, B-(2-methoxy-5-methylphenyl)-
  • (2-Methoxy-5-methylphenyl)boranediol
  • 127972-00-3
  • 27972-00-3
  • C6H3CH3OCH3BOH2
  • BORONIC ACID
  • Organometallic Reagents
  • Aryl
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Aryl
  • Organoborons
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Substituted Boronic Acids
  • blocks
  • BoronicAcids
  • Heterocyclic Compounds
  • Alkoxy