2-Methoxy-5-methylphenylboronic acid
- Product Name
- 2-Methoxy-5-methylphenylboronic acid
- CAS No.
- 127972-00-3
- Chemical Name
- 2-Methoxy-5-methylphenylboronic acid
- Synonyms
- AKOS BRN-0586;CHEMBRDG-BB 4008663;2-Methoxy-5-Methylphenylboroni;2-Methoxy-5-methylphenylboronic Aci;5-Methyl-2-methoxyphenylboronic acid;2-METHOXY-5-METHYLPHENYLBORONIC ACID;(2-Methoxy-5-methylphenyl)boranediol;5-METHOXY-2-METHYLPHENYL BORONIC ACID;(2-METHOXY-5-METHYLBENZENE)BORONIC ACID;2-Methoxy-5-methylphenylboronic acid >=95%
- CBNumber
- CB3742237
- Molecular Formula
- C8H11BO3
- Formula Weight
- 165.98
- MOL File
- 127972-00-3.mol
2-Methoxy-5-methylphenylboronic acid Property
- Melting point:
- 92-97 °C (lit.)
- Boiling point:
- 342.0±52.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in methanol.
- form
- powder to crystal
- pka
- 8.65±0.58(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 127972-00-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-60-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29319090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 567507
- Product name
- 2-Methoxy-5-methylphenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $127
- Updated
- 2023/06/20
- Product number
- 567507
- Product name
- 2-Methoxy-5-methylphenylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $290
- Updated
- 2023/06/20
- Product number
- M2311
- Product name
- 2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 5g
- Price
- $322
- Updated
- 2025/07/31
- Product number
- M2311
- Product name
- 2-Methoxy-5-methylphenylboronic Acid (contains varying amounts of Anhydride)
- Packaging
- 25g
- Price
- $1160
- Updated
- 2025/07/31
- Product number
- M330788
- Product name
- 2-Methoxy-5-methylphenylboronic acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
2-Methoxy-5-methylphenylboronic acid Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
Reactant for:
- Coupling reactions
- Preparation of selective quinazolinyl-phenol inhibitors of CHK1 as potential antitumors and radioprotectants
- Rh-catalyzed asymmetric arylation of aldehydes
- Stereoselective hydroarylation reactions
- Suzuki-Miyaura cross-coupling
Uses
suzuki reaction
Synthesis
121-43-7
22002-45-5
127972-00-3
To a solution of 2-bromo-1-methoxy-4-methylbenzene (1.39 g, 15 mmol) in tetrahydrofuran (THF) was slowly added n-butyllithium (15 mmol) dropwise under nitrogen protection and -78 °C. The solution was stirred for 1 h. The solution was then mixed with tetramethyl borate (100 mL). After maintaining -78 °C and stirring for 1 h, the solution was transferred to a solution of THF (100 mL) containing trimethyl borate (15 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously for 4 hours. Subsequently, the reaction mixture was poured into 3N hydrochloric acid (125 mL) and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the yellowish white solid product 2-methoxy-5-methylphenylboronic acid (2.2 g, 89% yield). The product was characterized by 1H NMR (300 MHz, d6-DMSO): δ 7.6 (s, 1H), 7.38 (d, J = 2.3 Hz, 1H), 7.19 (dd, J = 8.4 Hz, 2.3 Hz, 1H), 6.87 (d, J = 8.4 Hz, 1H), 3.78 (s, 3H), 2.2 (s, 3H).
References
[1] Patent: US2004/19190, 2004, A1. Location in patent: Page 24
[2] Patent: US5688808, 1997, A
[3] Patent: US5693646, 1997, A
[4] Patent: US5688810, 1997, A
[5] Patent: US5693647, 1997, A
2-Methoxy-5-methylphenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methoxy-5-methylphenylboronic acid Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 2-Methoxy-5-methylphenylboronic acid manufacturers
- Product
- 2-Methoxy-5-methylphenylboronic acid 127972-00-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Methoxy-5-methylphenylboronic acid 127972-00-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- 2-Methoxy-5-methylphenylboronic acid 127972-00-3
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customise
- Release date
- 2018-08-09