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tert-Butyl N-(2-bromoethyl)carbamate

Product Name
tert-Butyl N-(2-bromoethyl)carbamate
CAS No.
39684-80-5
Chemical Name
tert-Butyl N-(2-bromoethyl)carbamate
Synonyms
tert-butyl 2-bromoethylcarbamate;2-(BOC-AMINO)ETHYL BROMIDE;N-BOC-BROMOETHYLAMINE;N-BOC-2-BROMOETHYLAMINE;tert-Butyl N-;BOC-2-BROMOETHYLAMINE;Boc-aminoethylbromide;BOC-2-AMINOETHYLBROMIDE;N-T-BOC-2-BROMETHANAMINE;BOC-1-AMINO-2-BROMOETHANE
CBNumber
CB2351412
Molecular Formula
C7H14BrNO2
Formula Weight
224.1
MOL File
39684-80-5.mol
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tert-Butyl N-(2-bromoethyl)carbamate Property

Melting point:
30-32 °C(lit.)
Boiling point:
262.3±23.0 °C(Predicted)
Density 
1.321±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in Chloroform, Dichloromethane and Ethyl Acetate.
pka
11.76±0.46(Predicted)
form 
Liquid
color 
Clear colorless to yellow
BRN 
2325117
InChI
InChI=1S/C7H14BrNO2/c1-7(2,3)11-6(10)9-5-4-8/h4-5H2,1-3H3,(H,9,10)
InChIKey
TZRQZPMQUXEZMC-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NCCBr
CAS DataBase Reference
39684-80-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
F 
10-21
HazardClass 
IRRITANT
HS Code 
29241990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
17354
Product name
2-(Boc-amino)ethyl bromide
Purity
≥97.0% (GC)
Packaging
1g
Price
$68.3
Updated
2025/07/31
Sigma-Aldrich
Product number
17354
Product name
2-(Boc-amino)ethyl bromide
Purity
≥97.0% (GC)
Packaging
5g
Price
$160
Updated
2025/07/31
TCI Chemical
Product number
B2289
Product name
2-(tert-Butoxycarbonylamino)ethyl Bromide
Purity
>98.0%(GC)
Packaging
1g
Price
$66
Updated
2025/07/31
TCI Chemical
Product number
B2289
Product name
2-(tert-Butoxycarbonylamino)ethyl Bromide
Purity
>98.0%(GC)
Packaging
5g
Price
$198
Updated
2025/07/31
TCI Chemical
Product number
B2289
Product name
2-(tert-Butoxycarbonylamino)ethyl Bromide
Purity
>98.0%(GC)
Packaging
25g
Price
$594
Updated
2025/07/31
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tert-Butyl N-(2-bromoethyl)carbamate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

N-t-Boc-2-bromoethylamine is a building block for preparing fluorinated spacers having nucleophilic and electrophilic termini.

reaction suitability

reagent type: cross-linking reagent

Synthesis

107-09-5

24424-99-5

39684-80-5

Di-tert-butyl dicarbonate (80.0 g, 366 mmol) was slowly added to a solution of 2-bromoethylamine (75.0 g, 366 mmol) and triethylamine (100 mL, 732 mmol) in methanol (700 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, water (500 mL) was added for dilution and extracted with dichloromethane (2 x 500 mL). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give N-Boc-2-bromoethylamine (78.0 g, 92% yield) as a colorless oil. NMR hydrogen spectrum (400MHz, DMSO-d6) δ 7.08 (broad single peak, 1H), 3.42 (double peak, J=6.8Hz, 2H), 3.29 (double peak, J=6.8Hz, 2H), 1.39 (single peak, 9H).

References

[1] European Journal of Organic Chemistry, 2015, vol. 2015, # 29, p. 6458 - 6465
[2] Patent: WO2016/176423, 2016, A1. Location in patent: Page/Page column 120
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 14, p. 3213 - 3215
[4] Organic and Biomolecular Chemistry, 2013, vol. 11, # 26, p. 4414 - 4418
[5] Patent: US2014/134110, 2014, A1. Location in patent: Paragraph 0087; 0088; 0089

tert-Butyl N-(2-bromoethyl)carbamate Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate 2-Bromoethylamine hydrobromide Dichloromethane Potassium bisulfate

Preparation Products

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tert-Butyl N-(2-bromoethyl)carbamate Suppliers

Americas 1 Austria 1 Belgium 1 Canada 3 China 215 Europe 2 France 2 Germany 1 India 28 Japan 2 Switzerland 2 United Kingdom 7 United States 32 Global 297
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
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View Lastest Price from tert-Butyl N-(2-bromoethyl)carbamate manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
tert-Butyl N-(2-bromoethyl)carbamate 39684-80-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-10-09
R&D Scientific Inc.
Product
N-Boc-2-bromoethylamine 39684-80-5
Price
US $2600.00/Kg
Min. Order
1Kg
Purity
98
Supply Ability
500 Kg
Release date
2024-08-28
Career Henan Chemical Co
Product
tert-Butyl N-(2-bromoethyl)carbamate 39684-80-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-24

39684-80-5, tert-Butyl N-(2-bromoethyl)carbamateRelated Search:

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  • 39684-80-5
  • 684-80-5
  • C7H14NO2Br
  • C7H14BrNO2
  • BrCH2CH2NHCO2CCH33
  • C7H14NBrO2
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