Sodium tolmetin dihydrate

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Sodium tolmetin dihydrate

Product Name: Sodium tolmetin dihydrate
CAS No.: 64490-92-2
Chemical Name: Sodium tolmetin dihydrate
Synonyms: Tolmene;McN 2559-21-98;TOLMELINSODIUM;tolmetinsodiumdihydrate;sodiumtolmetindihydrate;Tolmetin Sodium (500 mg);Tolmetin Sodium (1670502);Tormetine Sodium (Dihydrate);TolMetin sodiuM salt dehydrate;TOLMETIN SODIUM SALT DIHYDRATE
CBNumber: CB2352833
Molecular Formula: C15H14NO3.Na.2H2O
Formula Weight: 315.3
MOL File: 64490-92-2.mol

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Sodium tolmetin dihydrate Property

Melting point:: 155-157 (dec.)
storage temp.: -20°C Freezer
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Beige
Water Solubility: Soluble in water
InChIKey: QQILXENAYPUNEA-UHFFFAOYSA-M
CAS DataBase Reference: 64490-92-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22-38
Safety Statements: 36
WGK Germany: 3
RTECS: UX9280000
HS Code: 2933995500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1670502
Product name: Tolmetin sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $174.4
Updated: 2024/03/01

Alfa Aesar

Product number: J62663
Product name: Tolmetin sodium salt dihydrate
Purity: 98+%
Packaging: 1g
Price: $43.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62663
Product name: Tolmetin sodium salt dihydrate
Purity: 98+%
Packaging: 5g
Price: $148.65
Updated: 2024/03/01

Cayman Chemical

Product number: 18195
Product name: Tolmetin (sodium salt hydrate)
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18195
Product name: Tolmetin (sodium salt hydrate)
Purity: ≥98%
Packaging: 5g
Price: $116
Updated: 2024/03/01

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Sodium tolmetin dihydrate Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

beta-adrenergic blocker

Uses

Anti-inflammatory.

Definition

ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.

Biological Activity

tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].

in vitro

tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].

in vivo

in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].

References

[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.
[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.
[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.
[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.

Sodium tolmetin dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sodium tolmetin dihydrate manufacturers

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Sodium tolmetin dihydrate 64490-92-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.10%
Supply Ability: 50000kg
Release date: 2024-04-22

Hebei Duling International Trade Co. LTD

Product: Sodium tolmetin dihydrate 64490-92-2
Price: US $50.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 20 tons
Release date: 2023-03-28

Hebei Mojin Biotechnology Co., Ltd

Product: Sodium tolmetin dihydrate 64490-92-2
Price: US $500.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: 200ton
Release date: 2023-07-25

64490-92-2, Sodium tolmetin dihydrateRelated Search:

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64490-92-2

C15H14NNaO32H2O

C15H14NNaO3

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C15H18NNaO5

C15H14NO3Na2H2O

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