Sodium tolmetin dihydrate

ChemicalBook > CAS DataBase List > Sodium tolmetin dihydrate

Sodium tolmetin dihydrate

Product Name: Sodium tolmetin dihydrate
CAS No.: 64490-92-2
Chemical Name: Sodium tolmetin dihydrate
Synonyms: Tolmene;McN 2559-21-98;TOLMELINSODIUM;tolmetinsodiumdihydrate;sodiumtolmetindihydrate;Tolmetin Sodium (500 mg);Tolmetin Sodium (1670502);Tormetine Sodium (Dihydrate);TolMetin sodiuM salt dehydrate;TOLMETIN SODIUM SALT DIHYDRATE
CBNumber: CB2352833
Molecular Formula: C15H14NO3.Na.2H2O
Formula Weight: 315.3
MOL File: 64490-92-2.mol

Less

Sodium tolmetin dihydrate Property

Melting point:: 155-157 (dec.)
storage temp.: -20°C Freezer
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Beige
Water Solubility: Soluble in water
InChIKey: QQILXENAYPUNEA-UHFFFAOYSA-M
CAS DataBase Reference: 64490-92-2(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-38
Safety Statements: 36
WGK Germany: 3
RTECS: UX9280000
HS Code: 2933995500

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1670502
Product name: Tolmetin sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $174.4
Updated: 2024/03/01

Alfa Aesar

Product number: J62663
Product name: Tolmetin sodium salt dihydrate
Purity: 98+%
Packaging: 1g
Price: $43.65
Updated: 2024/03/01

Alfa Aesar

Product number: J62663
Product name: Tolmetin sodium salt dihydrate
Purity: 98+%
Packaging: 5g
Price: $148.65
Updated: 2024/03/01

Cayman Chemical

Product number: 18195
Product name: Tolmetin (sodium salt hydrate)
Purity: ≥98%
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18195
Product name: Tolmetin (sodium salt hydrate)
Purity: ≥98%
Packaging: 5g
Price: $116
Updated: 2024/03/01

Less

Sodium tolmetin dihydrate Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

beta-adrenergic blocker

Uses

Anti-inflammatory.

Definition

ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.

Biological Activity

tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].

in vitro

tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].

in vivo

in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].

References

[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.
[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.
[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.
[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.

Sodium tolmetin dihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Sodium tolmetin dihydrate Suppliers

Canada 1 China 81 Europe 2 Germany 1 India 3 Switzerland 1 United Kingdom 3 United States 26 Global 118

Zhangjiagang huamao Fine chemical Co.,Ltd.

Tel: 0512-58327208; 13962221965
Fax: 0512-58327206
Email: sales@huamao-chem.com
Country: China
ProdList: 34
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Email: sales@capotchem.com
Country: China
ProdList: 18207
Advantage: 66

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400 638 7771
Email: sales@heowns.com
Country: China
ProdList: 14435
Advantage: 57

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1830
Advantage: 55

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9484
Advantage: 50

Taizhou Tianhong Biochemistry Technology Co., Ltd.

Tel: 0523-86132544 15366717810
Fax: 0523-86201489
Email: sales@thbiochem.com
Country: China
ProdList: 358
Advantage: 55

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Wuhai Shuou Technology Co., Ltd.

Tel: 17792809151
Fax: 18872220797
Email: 2355916837@ycphar.com
Country: China
ProdList: 6133
Advantage: 55

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718 +86-13336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29791
Advantage: 60

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6038 18902104717
Email: sales@heowns.com
Country: China
ProdList: 21085
Advantage: 60

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57412
Advantage: 58

Guangzhou Tomums Life Science Co., Ltd.

Tel: 020-31155029 18902330969
Fax: 020-31155029
Email: sales@tomums.cn
Country: China
ProdList: 4696
Advantage: 58

Hebei Mojin Biotechnology Co., Ltd

Tel: +86 13288715578 +8613288715578
Email: sales@hbmojin.com
Country: China
ProdList: 12840
Advantage: 58

Henan Alfa Chemical Co., Ltd

Tel: +86-18339805032; +8618339805032
Email: alfa4@alfachem.cn
Country: China
ProdList: 13227
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Hubei Ipure Biology Co., Ltd

Tel: +8613367258412
Fax: 18062427325
Email: ada@ipurechemical.com
Country: China
ProdList: 10319
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52849
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15354
Advantage: 58

Hebei Weibang Biotechnology Co., Ltd

Tel: +8615531157085
Fax: whatapp+8619930503282
Email: abby@weibangbio.com
Country: China
ProdList: 8812
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

Wuxi Kehua Biological Technology Co., Ltd.

Tel: 0510-0510-86838766
Email: 2258830676@qq.com
Country: China
ProdList: 4546
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Country: China
ProdList: 39894
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49374
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: wulan@absin.cn
Country: China
ProdList: 24731
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Changzhou Kechem Bio-Scientific Co., LTD.

Tel: 0519-68985668 13685222090
Fax: qq735434464
Email: sales@kechem.cn
Country: China
ProdList: 26028
Advantage: 58

Hebei mo Jin biotechnology co., ltd

Tel: 13288715578
Email: angelia@hbmojin.com
Country: China
ProdList: 1689
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4495
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6567
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44458
Advantage: 58

Hebei Momojin Biological Technology Co., Ltd

Tel: 0311-13383097 13383097021
Email: sales@hbmojin.com
Country: China
ProdList: 2973
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29774
Advantage: 58

ChemeGen 中国

Tel: 18818260767
Fax: QQ 3610331285
Email: 2625930290@qq.com
Country: China
ProdList: 6973
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24647
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29794
Advantage: 58

Jikang Chemical Industry Co. , Ltd.

Tel: 0573-85609002 18157336032
Email: zhejia01@163.com
Country: China
ProdList: 7859
Advantage: 58

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 18621169109
Email: market03@meryer.com
Country: China
ProdList: 27987
Advantage: 58

Wuhan woxuan Technology Co., Ltd

Tel: 13322067656
Email: 3199863540@qq.com
Country: China
ProdList: 5081
Advantage: 58

Less

View Lastest Price from Sodium tolmetin dihydrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Sodium tolmetin dihydrate 64490-92-2
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-06-06

Hebei Weibang Biotechnology Co., Ltd

Product: Sodium tolmetin dihydrate 64490-92-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2023-05-24

Hebei Mojin Biotechnology Co., Ltd

Product: Sodium tolmetin dihydrate 64490-92-2
Price: US $500.00/g
Min. Order: 100g
Purity: 99%
Supply Ability: 200ton
Release date: 2023-07-25

64490-92-2, Sodium tolmetin dihydrateRelated Search:

Phenylmethylsulfonyl fluoride Sodium phenylacetate 1-Methylpyrrolidine Sodium bicarbonate Sodium chloride Trisodium phosphate Diclofenac sodium Methyl acrylate Sodium acetate Methyl cellulose Tolmetin sodium Methylparaben Sodium hydroxide Pyrrole Phenoxyacetic acid sodium salt N-Methyl-2-pyrrolidone Sodium citrate Amtolmetin guacil

sodiumtolmetindihydrate

tolmetinsodiumdihydrate

1-methyl-5-(p-toluoyl)pyrrole-2-acetic acid sodium-potassium salt dihydrate

TOLMELINSODIUM

Tolmetinsodiumsaltdihydratecrystalline

1-Methyl-5-(4-methylbenzoyl)-1H-pyrrole-2-acetic Acid Sodium Dihydrate

1-Methyl-5-p-toluoylpyrrole-2-acetic Acid Sodium Dihydrate

5-[(p-Tolyl)carbonyl]-1-methylpyrrole-2-acetic Acid Sodium Dihydrate

McN 2559-21-98

Tolmene

1-Methyl-5-(p-toluoyl)pyrrole-2-acetic acid dihydrate sodium-potassium salt

Tolmetin dihydrate sodium salt

TolMetin SodiuM Salt, Dihydrate, USP

sodiuM 2,2-dihydroxy-2-{1-Methyl-5-[(4-Methylphenyl)carbonyl]-1H-pyrrol-2-yl}acetic acid

Sodium 2-(1-methyl-5-(4-methylbenzoyl)-1H-pyrrol-2-yl)acetate dihydrate

Tolmetin Sodium (500 mg)

TolMetin sodiuM salt dehydrate

TOLMETIN SODIUM SALT DIHYDRATE

TOLMETIN SODIUM SALT: DIHYDRATE

1h-pyrrole-2-aceticacid,1-methyl-5-(4-methylbenzoyl)-,sodiumsalt,dihydrate

1-METHYL-5-(P-TOLUOYL)PYRROLE-2-ACETIC ACID SODIUM SALT, DIHYDRATE

1-METHYL-5-[P-TOLUOYL]PYRROLE-2-ACETIC ACID SODIUM SALT: DIHYDRATE

sodium 2-[1-methyl-5-[(4-methylphenyl)-oxomethyl]-2-pyrrolyl]acetate dihydrate

sodium1-methyl-5-p-toluoylpyrrole-2-acetatedihydrate

Tolmetin (sodium salt hydrate)

Tormetine Sodium (Dihydrate)

Tolmetin Sodium(Secondary Standards traceble to USP)

Tolmetin Sodium (1670502)

64490-92-2

C15H14NNaO32H2O

C15H14NNaO3

C15H19NNaO5

C15H18NNaO5

C15H14NO3Na2H2O

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

BETAGAN

API intermediates