Sodium tolmetin dihydrate
- Product Name
- Sodium tolmetin dihydrate
- CAS No.
- 64490-92-2
- Chemical Name
- Sodium tolmetin dihydrate
- Synonyms
- Tolmene;McN 2559-21-98;TOLMELINSODIUM;tolmetinsodiumdihydrate;sodiumtolmetindihydrate;Tolmetin Sodium (500 mg);Tolmetin Sodium (1670502);Tormetine Sodium (Dihydrate);TolMetin sodiuM salt dehydrate;TOLMETIN SODIUM SALT DIHYDRATE
- CBNumber
- CB2352833
- Molecular Formula
- C15H14NO3.Na.2H2O
- Formula Weight
- 315.3
- MOL File
- 64490-92-2.mol
Sodium tolmetin dihydrate Property
- Melting point:
- 155-157 (dec.)
- storage temp.
- -20°C Freezer
- solubility
- Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Beige
- Water Solubility
- Soluble in water
- InChIKey
- QQILXENAYPUNEA-UHFFFAOYSA-M
- CAS DataBase Reference
- 64490-92-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 1670502
- Product name
- Tolmetin sodium
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $174.4
- Updated
- 2024/03/01
- Product number
- J62663
- Product name
- Tolmetin sodium salt dihydrate
- Purity
- 98+%
- Packaging
- 1g
- Price
- $43.65
- Updated
- 2024/03/01
- Product number
- J62663
- Product name
- Tolmetin sodium salt dihydrate
- Purity
- 98+%
- Packaging
- 5g
- Price
- $148.65
- Updated
- 2024/03/01
- Product number
- 18195
- Product name
- Tolmetin (sodium salt hydrate)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 18195
- Product name
- Tolmetin (sodium salt hydrate)
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $116
- Updated
- 2024/03/01
Sodium tolmetin dihydrate Chemical Properties,Usage,Production
Chemical Properties
Crystalline Solid
Uses
beta-adrenergic blocker
Uses
Anti-inflammatory.
Definition
ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.
Biological Activity
tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].
in vitro
tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].
in vivo
in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].
References
[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.
[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.
[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.
[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.
Sodium tolmetin dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
Sodium tolmetin dihydrate Suppliers
- Tel
- --
- Fax
- --
- standards@synzeal.com
- Country
- India
- ProdList
- 6514
- Advantage
- 58
- Tel
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- Fax
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- mktg@pharmaffiliates.com
- Country
- India
- ProdList
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- Advantage
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View Lastest Price from Sodium tolmetin dihydrate manufacturers
- Product
- Sodium tolmetin dihydrate 64490-92-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-06-06
- Product
- Sodium tolmetin dihydrate 64490-92-2
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2023-05-24
- Product
- Sodium tolmetin dihydrate 64490-92-2
- Price
- US $500.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- 200ton
- Release date
- 2023-07-25