BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- Product Name
- BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- CAS No.
- 39945-51-2
- Chemical Name
- BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
- Synonyms
- BUTTPARK 75\50-54;N-CBZ-3-piperidinol;N-Cbz-3-hydroxymethylpiperidine;1-CBZ-3-HYDROXYMETHYL-PIPERIDINE;3-(Hydroxymethyl)piperidine, N-CBZ protected;1-Cbz-3-(hydroxymethyl)piperidine - [H12354];1-Benzyloxycarbonyl-3-piperidineMethanol, 97%;1-BENZYLOXYCARBONYL-3-(HYDROXYMETHYL)PIPERIDINE;BENZYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate
- CBNumber
- CB2372657
- Molecular Formula
- C14H19NO3
- Formula Weight
- 249.31
- MOL File
- 39945-51-2.mol
BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property
- Melting point:
- 59-60℃
- Boiling point:
- 396.4±25.0 °C(Predicted)
- Density
- 1.162±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.93±0.10(Predicted)
- Appearance
- Colorless to light yellow Viscous liquid
- CAS DataBase Reference
- 39945-51-2(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-36/37/39
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B278810
- Product name
- Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate
- Packaging
- 1g
- Price
- $95
- Updated
- 2021/12/16
- Product number
- B278810
- Product name
- Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- OR23396
- Product name
- 3-(Hydroxymethyl)piperidine,N-CBZprotected
- Packaging
- 1g
- Price
- $19
- Updated
- 2021/12/16
- Product number
- 4H56-1-UK
- Product name
- 3-(Hydroxymethyl)piperidine, N-Cbz protected
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- FB51015
- Product name
- Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production
Chemical Properties
White to off-white crystal powder
Uses
Benzyl 3-(Hydroxymethyl)piperidine-1-carboxylate is an intermediate used in the synthesis of disubstituted pyrimidines as Lck inhibitors.
Synthesis
4606-65-9
501-53-1
39945-51-2
Triethylamine (0.51 g, 5 mmol) was added to a frozen solution of 3-hydroxymethylpiperidine (0.61 g, 5 mmol) in dichloromethane (10 mL), followed by slow dropwise addition of benzyl chloroformate (0.88 g, 5 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. After completion of the reaction, dichloromethane (50 mL) was added to dilute the reaction mixture, and the organic layer was washed sequentially with 5% hydrochloric acid solution (2 × 20 mL), saturated sodium bicarbonate solution (20 mL), and saturated sodium chloride solution (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered to remove the desiccant, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, ethyl acetate/hexane as eluent) to afford the target compound 3-methanol-N-benzyloxycarbonylpiperidine (1.21 g, 96% yield) as a colorless oil.1H NMR (CDCl3) δ: 1.20-1.83 (m, 5H), 2.78-3.20 (m, 2H), 3.50 (s, 2H), 3.69-4.05 (m, 2H), 5.14 (s, 2H), 7.25-7.40 (m, 5H).
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 5975 - 5983
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 9, p. 2673 - 2676
[3] Patent: WO2005/806, 2005, A2. Location in patent: Page 85
[4] Patent: US2010/48606, 2010, A1. Location in patent: Page/Page column 32
[5] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 51
BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Suppliers
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View Lastest Price from BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE manufacturers
- Product
- BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 39945-51-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20ton
- Release date
- 2020-10-28
- Product
- BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 39945-51-2
- Price
- US $10.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 99%
- Supply Ability
- 500tons/month
- Release date
- 2021-09-26