ChemicalBook > CAS DataBase List > BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

Product Name: BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
CAS No.: 39945-51-2
Chemical Name: BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Synonyms: BUTTPARK 75\50-54;N-CBZ-3-piperidinol;N-Cbz-3-hydroxymethylpiperidine;1-CBZ-3-HYDROXYMETHYL-PIPERIDINE;3-(Hydroxymethyl)piperidine, N-CBZ protected;1-Cbz-3-(hydroxymethyl)piperidine - [H12354];1-Benzyloxycarbonyl-3-piperidineMethanol, 97%;1-BENZYLOXYCARBONYL-3-(HYDROXYMETHYL)PIPERIDINE;BENZYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate
CBNumber: CB2372657
Molecular Formula: C14H19NO3
Formula Weight: 249.31
MOL File: 39945-51-2.mol

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BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property

Melting point:: 59-60℃
Boiling point:: 396.4±25.0 °C(Predicted)
Density: 1.162±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.93±0.10(Predicted)
Appearance: Colorless to light yellow Viscous liquid
CAS DataBase Reference: 39945-51-2(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38-36
Safety Statements: 26-36/37/39
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B278810
Product name: Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate
Packaging: 5g
Price: $250
Updated: 2021/12/16

TRC

Product number: B278810
Product name: Benzyl3-(Hydroxymethyl)piperidine-1-carboxylate
Packaging: 1g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51015
Product name: Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate
Packaging: 1g
Price: $107
Updated: 2021/12/16

Apolloscientific

Product number: OR23396
Product name: 3-(Hydroxymethyl)piperidine,N-CBZprotected
Packaging: 1g
Price: $19
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-UK
Product name: 3-(Hydroxymethyl)piperidine, N-Cbz protected
Packaging: 1g
Price: $21
Updated: 2021/12/16

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BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

White to off-white crystal powder

Uses

Benzyl 3-(Hydroxymethyl)piperidine-1-carboxylate is an intermediate used in the synthesis of disubstituted pyrimidines as Lck inhibitors.

Synthesis

4606-65-9

501-53-1

39945-51-2

Triethylamine (0.51 g, 5 mmol) was added to a frozen solution of 3-hydroxymethylpiperidine (0.61 g, 5 mmol) in dichloromethane (10 mL), followed by slow dropwise addition of benzyl chloroformate (0.88 g, 5 mmol). The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. After completion of the reaction, dichloromethane (50 mL) was added to dilute the reaction mixture, and the organic layer was washed sequentially with 5% hydrochloric acid solution (2 × 20 mL), saturated sodium bicarbonate solution (20 mL), and saturated sodium chloride solution (20 mL). The organic layer was dried over anhydrous sodium sulfate, filtered to remove the desiccant, and concentrated under reduced pressure to remove the solvent. The crude product was purified by fast column chromatography (silica gel, ethyl acetate/hexane as eluent) to afford the target compound 3-methanol-N-benzyloxycarbonylpiperidine (1.21 g, 96% yield) as a colorless oil.1H NMR (CDCl3) δ: 1.20-1.83 (m, 5H), 2.78-3.20 (m, 2H), 3.50 (s, 2H), 3.69-4.05 (m, 2H), 5.14 (s, 2H), 7.25-7.40 (m, 5H).

References

[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 20, p. 5975 - 5983
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 9, p. 2673 - 2676
[3] Patent: WO2005/806, 2005, A2. Location in patent: Page 85
[4] Patent: US2010/48606, 2010, A1. Location in patent: Page/Page column 32
[5] Patent: EP1780210, 2007, A1. Location in patent: Page/Page column 51

BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE manufacturers

Career Henan Chemica Co

Product: BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 39945-51-2
Price: US $1.00/g
Min. Order: 1g
Purity: 85.0-99.8%
Supply Ability: 20ton
Release date: 2020-10-28

Shanxi Naipu Import and Export Co.,Ltd

Product: BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 39945-51-2
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 500tons/month
Release date: 2021-09-26

39945-51-2, BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATERelated Search:

BENZYL ETHYL PIPERIDINE-1,3-DICARBOXYLATE BENZYL 4-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-N-CBZ-NIPECOTAMIDE 3-Piperidinemethanol N- Cbz-2-piperidinemethanol (S)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-METHYL ESTER 3-Boc-Amino-1-Cbz-piperidine-3-carboxylic acid BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE 1-[(Benzyloxy)carbonyl]-3-piperidinecarboxylic acid N-CBZ-3-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER ETHYL (S)-1-CBZ-NIPECOTATE (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 4-Oxo-1,3-piperidinedicarboxylic acid 1-benzyl ester 3-methyl ester 2S,3S-1-CBZ-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID 4-OXO-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 3-ETHYL ESTER 2S,3R-1-CBZ-2-METHYL-PIPERIDINE-3-CARBOXYLIC ACID

3-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER

N-Cbz-3-hydroxymethylpiperidine

1-BENZYLOXYCARBONYL-3-(HYDROXYMETHYL)PIPERIDINE

1-CBZ-3-HYDROXYMETHYL-PIPERIDINE

BENZYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

BENZYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

BUTTPARK 75\50-54

3-(Hydroxymethyl)piperidine, N-CBZ protected

Benzyl 3-(hydroxymethyl)piperidine-1-carboxylate, [(Benzyloxy)carbonyl]piperidin-3-yl]methanol

benzyl (3S)-3-(hydroxyMethyl)piperidine-1-carboxylate

1-Benzyloxycarbonyl-3-piperidineMethanol, 97%

benzyl 3-(hydroxymethyl)-1-piperidinecarboxylate

1-Piperidinecarboxylic acid, 3-(hydroxymethyl)-, phenylmethyl ester

N-CBZ-3-piperidinol

1-Cbz-3-(hydroxymethyl)piperidine - [H12354]

39945-51-2

139945-51-2