Flunarizine dihydrochloride

Product Name: Flunarizine dihydrochloride
CAS No.: 30484-77-6
Chemical Name: Flunarizine dihydrochloride
Synonyms: FLUNARIZINE HCL;FLUNARIZINE HYDROCHLORIDE;Gradient;Flunarizine dihydrochloride CRS;Issium;Mondus;r14950;Flunarl;kw-3149;Flunagen
CBNumber: CB2377940
Molecular Formula: C26H28Cl2F2N2
Formula Weight: 477.42
MOL File: 30484-77-6.mol

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Flunarizine dihydrochloride Property

Melting point:: 188-190?C
storage temp.: 2-8°C
solubility: chloroform/methanol (9:1): 50 mg/mL, clear, colorless
form: Solid
color: White to Off-White
Merck: 13,4170
BRN: 4284243
CAS DataBase Reference: 30484-77-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: TK9187000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: F8257
Product name: Flunarizine dihydrochloride
Purity: ≥98% (TLC)
Packaging: 1g
Price: $79.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: F8257
Product name: Flunarizine dihydrochloride
Purity: ≥98% (TLC)
Packaging: 10g
Price: $469
Updated: 2024/03/01

Alfa Aesar

Product number: J62969
Product name: Flunarizine dihydrochloride, 99%
Packaging: 1g
Price: $62.65
Updated: 2024/03/01

Cayman Chemical

Product number: 20385
Product name: Flunarizine (hydrochloride)
Purity: ≥98%
Packaging: 1g
Price: $36
Updated: 2024/03/01

Cayman Chemical

Product number: 20385
Product name: Flunarizine (hydrochloride)
Purity: ≥98%
Packaging: 5g
Price: $163
Updated: 2024/03/01

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Flunarizine dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Sibelium,Janssen,W. Germany,1977

Uses

antipsychotic, H1 antihistamine

Uses

Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.

Uses

Calcium channel blocker; fluorinated derivative of Cinnarizine. Vasodilator (cerebral and peripheral). This is the labeled analog.

Definition

ChEBI: Flunarizine hydrochloride is a diarylmethane.

Manufacturing Process

A mixture of 14.3 parts of di-(p-fluorophenyl)-chloromethane, 10.1 parts of 1- cinnamylpiperazine, 12.7 parts of sodium carbonate, a few crystals of potassium iodide in 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 21 hours. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried, filtered and evaporated.
The oily residue is dissolved in 480 parts of anhydrous diisopropyl ether. This solution is boiled with activated charcoal, filtered and to the clear filtrate is added an excess of 2-propanol, previously saturated with gaseous hydrogen chloride. The precipitated salt is filtered off and recrystallized from a mixture of 2-propanol and ethanol, yielding 1-cinnamyl-4-(di-p-fluorobenzhydryl) piperazine dihydrochloride, MP 251.5°C.

Therapeutic Function

Vasodilator

General Description

Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.

Biological Activity

Dual Na + /Ca 2+ channel blocker; a cerebral and peripheral vasodilator. Neuroprotective.

Biochem/physiol Actions

Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells

Flunarizine dihydrochloride Preparation Products And Raw materials

Raw materials

Fluorobenzene Cinnamyl alcohol Piperazine Fluoroboric acid 4,4'-Methylenedianiline

Preparation Products

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Flunarizine dihydrochloride Suppliers

Austria 1 Belgium 2 Canada 3 China 268 Europe 2 France 3 Germany 1 India 46 Italy 1 Japan 1 Malaysia 1 Nepal 1 Nigeria 1 Poland 1 Singapore 1 South Korea 1 Spain 1 Switzerland 3 United Arab Emirates 1 United Kingdom 15 United States 34 Global 388

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View Lastest Price from Flunarizine dihydrochloride manufacturers

WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Product: Flunarizine dihydrochloride 30484-77-6
Price: US $0.00/KG
Min. Order: 100g
Purity: 98%+
Supply Ability: 100kg
Release date: 2020-10-24

Hebei Zhanyao Biotechnology Co. Ltd

Product: Flunarizine dihydrochloride 30484-77-6
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-02

Zhuozhou Wenxi import and Export Co., Ltd

Product: Flunarizine dihydrochloride 30484-77-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

30484-77-6, Flunarizine dihydrochlorideRelated Search:

Bensulfuron methyl Kresoxim-methyl Methyl acrylate 2-METHYL-2-PROPENE-1-SULFONIC ACID SODIUM SALT Methacryloyl chloride Flunarizine 1-Methylpiperazine DIPHENYLCYCLOPROPENONE N,N'-Methylenebisacrylamide Methacrolein Methylparaben Thiophanate-methyl Piperazine 1-AdaMantanethylaMine PHENYL VALERATE Methyl Dihydrochloride 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride

Flugeral

Flunarl

Fluxarten

Gradient

Issium

Flunarizine dihydrochloride,1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride

Flunarizine-d8 dihydrochloride

1-[Bis(4-fluorophenyl)Methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine Hydrochloride

Dinaplex

Flunagen

Mondus

Flunarizine Dihydrochloride (EP/BP)

Piperazine,1-[bis(4-fluorophenyl)Methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride(1:2)

1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-piperazine,hydrochloride (1:2)

(e)-1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazinedihydroch

1-(BIS[4-FLUOROPHENYL]) DIHYDROCHLORIDE

1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE 2 HCL

1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLO RIDE

(e)-1-(bis(p-fluorophenyl)methyl)-4-cinnamylpiperazinedihydrochloride

1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-,dihydrochloride,(e)-piperazin

kw-3149

r14950

(E)-1-[BIS(4-FLUOROPHENYL)METHYL]-4-(3-PHENYL-2-PROPENYL)PIPERAZINE DIHYDROCHLORIDE

FLUNARIZINE 2HCL

FLUNARIZINE DIHYDROCHLORIDE

FLUNARIZINE HCL

FLUNARIZINE HYDROCHLORIDE

Flunarizine, DiHCl

(E)-1-[bis(4-fluorophenyl)methyl]-4-cinnamylpiperazine dihydrochloride

FLUNARIZINE DIHYDROCHLORIDE CA2+/NA+ CHA NNEL ANTA

FLUNARIZIN-DIHYDROCHLORIDE

FLUNARIZINE HYDROCHLORIDE EPF(CRM STANDARD)

1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine dihydrochloride

Flunarizine dihydrochloride CRS

Flunarizine dihydrochloride for system suitability CRS

Flunarizine dihydrochloride USP/EP/BP

Flunarizine dihydrochloride for system suitability (Y0000266)

1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride

FLURIZINE EP IMPURITY D

30484-77-6

30784-77-6

30848-77-6

C26H26F2N22HCl

C26H26F2N22ClH

C26H28Cl2F2N2

C26H28F2N2

47742

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