Roquinimex

Product Name: Roquinimex
CAS No.: 84088-42-6
Chemical Name: Roquinimex
Synonyms: FCF89;CS-1231;LS-2616;LINOMIDE;ABR212616;ROQUINIMEX;PNU 212616;Roquinimex(Linomide);N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide;1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide
CBNumber: CB2391777
Molecular Formula: C18H16N2O3
Formula Weight: 308.33
MOL File: 84088-42-6.mol

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Roquinimex Property

Melting point:: 200-204°
Boiling point:: 436.2±45.0 °C(Predicted)
Density: 1.357±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: 11 mg/mL
form: solid
pka: 4.50±1.00(Predicted)
color: White to off-white
Merck: 14,8259

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36/37
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
HS Code: 2933.49.2600

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

TCI Chemical

Product number: L0270
Product name: Linomide
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $170
Updated: 2024/03/01

Alfa Aesar

Product number: J65453
Product name: Linomide
Packaging: 10mg
Price: $174.65
Updated: 2024/03/01

Cayman Chemical

Product number: 30206
Product name: Roquinimex
Packaging: 5mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 30206
Product name: Roquinimex
Packaging: 100mg
Price: $700
Updated: 2024/03/01

Cayman Chemical

Product number: 30206
Product name: Roquinimex
Packaging: 10mg
Price: $168
Updated: 2024/03/01

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Roquinimex Chemical Properties,Usage,Production

Description

Roquinimex is an immunomodulator with diverse biological activities. In vivo, roquinimex (80 mg/kg) increases the number of myocardial MHC class II-expressing cells, the ratio of cytotoxic to helper T cells, and survival and decreases necrotic lesion area in a mouse model of murine coxsackievirus B3-induced myocarditis. It induces IFN-γ production, reduces TNF-α and IL-1β production, prevents the development of proteinuria, and ameliorates nephritis in a mouse model of chronic graft versus host disease (GVHD). Roquinimex (300 mg/kg) decreases colonic myeloperoxidase (MPO) activity and mucosal damage in a mouse model of colitis induced by dextran sulfate (DSS; ). It also decreases tumor weight and tumor blood flow in a von Hippel-Lindau (VHL) type 2a paraganglioma mouse xenograft model.

Uses

Biological response modifier; immunomodulator.

Uses

An immunomodulator with antitumour properties. Inhibits T-cell apoptosis in vivo; also inhibits angiogenesis in rats

Definition

ChEBI: 4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide is an aromatic amide.

Biological Activity

Immunomodulator with stimulatory and antitumor properties. Inhibits in vivo apoptosis of T-cells and inhibits angiogenesis in rats in vivo .

Roquinimex Preparation Products And Raw materials

Raw materials

Preparation Products

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Roquinimex Suppliers

Americas 1 China 65 Europe 2 Germany 5 India 2 Japan 1 Switzerland 1 United Kingdom 5 United States 30 Global 112

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84088-42-6, RoquinimexRelated Search:

Dimethyl sebacate N,N-Dimethylformamide Dimethyl carbonate Dimethyl phthalate ETHANE Dihydromyrcenol Dimethyl sulfoxide Dimethyl ether Dimethyl fumarate CIVENTICHEM CV-4057 Roquinimex

N-PHENYLMETHYL-1,2-DIHYDRO-4-HYDROXYL-N,1-DIMETHYL-2-OXO-QUINOLINE-3-CARBOXAMIDE

ROQUINIMEX

LINOMIDE

LS-2616

1,2-DIHYDRO-4-HYDROXY-N,1-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE

1,2-DIHYDRO-4-HYDROXY-N,N-DIMETHYL-2-OXO-N-PHENYL-3-QUINOLINECARBOXAMIDE

CS-1231

Roquinimex(Linomide)

4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

1,2-Dihydro-4-hydroxy-1,N-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide

N,1-Dimethyl-N-phenyl-2-oxo-4-hydroxy-1,2-dihydroquinoline-3-carboxamide

PNU 212616

N-phenyl-N-Methyl-1,2-dihydro-4-hydroxy-1-Methyl-2-oxo-quinoline-3-carboxaMide

ABR212616

FCF89

3-Quinolinecarboxamide, 1,2-dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-

Tumor Necrosis Factor Receptor,FCF-89,TNF Receptor,TNFR,Roquinimex,Inhibitor,ABR-212616,ABR 212616,FCF 89,inhibit

84088-42-6

C18H16N2O3

Cell Signaling and Neuroscience

Cell Biology

BioChemical

Immune System Regulation

Immunomodulators and Antibiotics

Immune Cell Signaling and Blood

Antitumour