BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE
- Product Name
- BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE
- CAS No.
- 121505-93-9
- Chemical Name
- BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE
- Synonyms
- Boc-Gly-N(OMe);BOC-GLY-N(OME)ME;BOC-GLY-NME(OME);(Tert-Butoxy)Carbonyl Gly-N(OMe)Me;BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE;N-Boc-glycine N'-methoxy-N'-methylamide;2-(Boc-amino)-N-methoxy-N-methylacetamide;N-alpha-Boc-glycine-N-methyl-N-methoxy amide;BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE USP/EP/BP;Boc-glycineN,O-dimethylhydroxamide≥ 99% (HPLC)
- CBNumber
- CB2391904
- Molecular Formula
- C9H18N2O4
- Formula Weight
- 218.25
- MOL File
- 121505-93-9.mol
BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE Property
- Melting point:
- 100-104 °C(lit.)
- Density
- 1.090±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 11.03±0.46(Predicted)
- color
- White to Off-White
- InChI
- InChI=1S/C9H18N2O4/c1-9(2,3)15-8(13)10-6-7(12)11(4)14-5/h6H2,1-5H3,(H,10,13)
- InChIKey
- XJVZHKXGDQXSNT-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NCC(N(OC)C)=O
Safety
- WGK Germany
- 3
- HS Code
- 2924190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- 465127
- Product name
- N-(tert-Butoxycarbonyl)glycine N′-methoxy-N′-methylamide
- Purity
- 98%
- Packaging
- 5g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- B692970
- Product name
- tert-Butyl(2-(Methoxy(methyl)amino)-2-oxoethyl)carbamate
- Packaging
- 10g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FB35864
- Product name
- N-(tert-Butoxycarbonyl)glycine N'-methoxy-N'-methylamide
- Packaging
- 5G
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 110803
- Product name
- Boc-Gly-N(OMe)Me
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 05079
- Product name
- Boc-glycineN,O-dimethylhydroxamide,99%(HPLC)
- Purity
- 99%(HPLC)
- Packaging
- 25G
- Price
- $106.4
- Updated
- 2021/12/16
BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
α-Amino Weinreb amide.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
4530-20-5
1117-97-1
121505-93-9
To a stirred solution of (tert-butoxycarbonyl)glycine (5.0 g, 28.57 mmol) and triethylamine (4.1 mL, 31.42 mmol) in dichloromethane (80 mL) was added N,O-dimethylhydroxylamine hydrochloride (3.0 g, 31.42 mmol). Subsequently, the reaction mixture was stirred at room temperature for 12 hours by dropwise addition of a solution of N,N'-dicyclohexylcarbodiimide (6.5 g, 31.42 mmol) in dichloromethane (20 mL). The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was filtered through diatomaceous earth and washed with dichloromethane. The filtrate was concentrated under reduced pressure to give the crude product, which was purified by silica gel column chromatography using 10% ethyl acetate/hexane as eluent to give the final N-BOC-glycine-N'-methoxy-N'-methylamide (6.0 g, 97.0%) as an off-white solid.1H NMR (400 MHz, CDCl3): δ 5.27 (broad single peak, 1H), δ 4.08 (broad single peak, 2H), 3.72 (single peak, 3H), 3.21 (single peak, 3H), 1.46 (single peak, 9H).
References
[1] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 226-227
[2] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 12, p. 2180 - 2183
[3] Journal of Organic Chemistry, 2006, vol. 71, # 17, p. 6678 - 6681
[4] Nucleosides, Nucleotides and Nucleic Acids, 2001, vol. 20, # 4-7, p. 1393 - 1397
[5] Arzneimittel-Forschung/Drug Research, 1989, vol. 39, # 4, p. 432 - 437
BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE Suppliers
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View Lastest Price from BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE manufacturers
- Product
- BOC-GLYCINE N,O-DIMETHYLHYDROXAMIDE 121505-93-9
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-09