Phthalylsulfathiazole

ChemicalBook > CAS DataBase List > Phthalylsulfathiazole

Phthalylsulfathiazole

Product Name: Phthalylsulfathiazole
CAS No.: 85-73-4
Chemical Name: Phthalylsulfathiazole
Synonyms: PST;ST8SIA4;Talidine;Thalinil;MGC34450;MGC61459;Anti-PST;Ftalazol;Taloudron;Thalazole
CBNumber: CB2405964
Molecular Formula: C17H13N3O5S2
Formula Weight: 403.43
MOL File: 85-73-4.mol

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Phthalylsulfathiazole Property

Melting point:: 198-204°C
Boiling point:: 371.31℃[at 101 325 Pa]
Density: 1.4235 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.6390 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent).
pka: 3.40±0.36(Predicted)
color: White to Light Yellow
Water Solubility: 400mg/L at 28℃
Merck: 14,7377
BRN: 359901
LogP: -2 at 28℃
CAS DataBase Reference: 85-73-4(CAS DataBase Reference)
NIST Chemistry Reference: Phthalylsulfathiazole(85-73-4)
EPA Substance Registry System: Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- (85-73-4)

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Safety

Safety Statements: 24/25
RIDADR: 3249
RTECS: TH8575000
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29350090
Toxicity: LD50 i.p. in mice: 920 mg/kg (Mattis)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: WH0006817M1
Product name: Monoclonal Anti-SULT1A1 antibody produced in mouse
Purity: clone 1F8, ascites fluid
Packaging: 200μL
Price: $524
Updated: 2024/03/01

Sigma-Aldrich

Product number: P1500000
Product name: Phthalylsulfathiazole
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: p1500000
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA053995
Product name: Anti-ST8SIA4 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging: 100μL
Price: $580
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA051126
Product name: Anti-ST8SIA4 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 100μL
Price: $580
Updated: 2024/03/01

Sigma-Aldrich

Product number: HPA049500
Product name: Anti-SULT1A1 antibody produced in rabbit
Purity: Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging: 100μL
Price: $547
Updated: 2024/03/01

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Phthalylsulfathiazole Chemical Properties,Usage,Production

Chemical Properties

White or yellowish-white, crystalline powder.

Originator

Sulfathalidine, MSD, US,1946

Uses

Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.

Definition

ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.

Preparation

It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.
It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.

Manufacturing Process

5 g of phthalic anhydride was added to a boiling suspension of 10 g of sulfathiazole in 100 cc of alcohol. The mixture was then refluxed for 5 minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water, The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-phthalylsulfanilamidothiazole,which decomposes above 260°C, according to US Patent 2,324,015.

brand name

Canidis-anti-diarr;Carbidiar;Carbotalin;Colicitina;Coliclase;Crematalil;Diacolin;Direver;Disenterol;Ef-micin;Enterocalme;Entero-hermes;Entero-red;Enterosteril;Entero-toxan;Esteraplidin mag;Eugeniteed;Fitazil;Ftalil-tiazol;Ilentazol;Inrestibla strepto;Iodentero-neomicina;Logical;Massotalil;Neo-sulfazon;Novosulfina;Phtazol;Septiftalil;Syptan;Talisulfazol;Tamil;.

Therapeutic Function

Antibacterial (intestinal)

World Health Organization (WHO)

Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.

Flammability and Explosibility

Non flammable

Mode of action

Phthalylsulfathiazole is of low inherent toxicity. Besides, it also enjoys an additional plus point for being only slightly absorbed by the intestinal mucosa ; and, therefore, may be safely administered in comparatively large doses in the management and treatment of bacillary infections of the intestine. The drug is not absorbed orally and is mostly employed for ulcerative colitis.

Phthalylsulfathiazole Preparation Products And Raw materials

Raw materials

Sulfathiazole

Preparation Products

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View Lastest Price from Phthalylsulfathiazole manufacturers

Baoji Guokang Bio-Technology Co., Ltd.

Product: Phthalylsulfathiazole 85-73-4
Price: US $95.00/Kg/Bag
Min. Order: 1KG
Purity: 99%
Supply Ability: 1T
Release date: 2021-06-04

Hebei Zhanyao Biotechnology Co. Ltd

Product: Phthalylsulfathiazole 85-73-4
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2022-01-25

Qiuxian Baitai New Material Co., LTD

Product: Phthalylsulfathiazole 85-73-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200000pcs
Release date: 2021-03-22

85-73-4, PhthalylsulfathiazoleRelated Search:

Dibenzoylmethane 2-Aminothiazole PYRAZOPHOS Sulfathiazole sodium ALTRENOGEST Sulfanilamide PHENYL VALERATE Sulfathiazole Glycine 4-Aminobenzoic acid Thiazole Benzoyl peroxide Phenylhydrazine PHTHALYLSULFACETAMIDE Phthalhydrazide Phthalazine Phthalic anhydride Phthaloyl amlodipine

4'-(2-THIAZOLYLSULFAMYL)PHTHALANILIC ACID

2-[[[4-[(2-THIAZOLYLAMINO)SULFONYL]PHENYLAMINO]CARBONYL]BENZOIC ACID

2-(N4-PHTHALYSULFANILAMIDO)THIAZOLE

2-(N-PHTHALYLAMINOBENZENESULFONAMIDO)THIAZOLE

N4-PHTHALYLSULFATHIAZOLE

PST

PHTHALYLSULFATHIAZOLE

PHTHALYLSULFATHIOZOLE

PHTHALYLSULPHATHIAZOLE

SULFATHALIDINE

4-(2-THIAZOLYLSULFAMYL)PHTHALANILIC ACID 95+%

2-[(((4-[(2-Thiozolylamino)sulfonyl]phenyl]amino]carbonyl]benzoic acid

2-[[4-[(2-Thiazolyl)sulfamoyl]phenyl]carbamoyl]benzoic acid

N-[4-(2-Thiazolylsulfamoyl)phenyl]phthalamic acid

N-[4-(2-Thiazolylsulfamoyl)phenyl]phthalamidic acid

Phthalylsulfathiazo

Phtalylsulfathiazole

(o-Carboxybenzoyl)-p-aminophenylsulfonamidothiazole

2-((4-[(1,3-Thiazol-2-ylamino)sulfonyl]anilino)carbonyl)benzoic acid

2-(n(sup4)-phthalyaminobenzenesulfonamide)thiazole

2-(n(sup4)-phthalyaminobenzenesulfonamido)thiazole

2-(n(sup4)-phthalylsulfanilamido)thiazole

2-(N4-phthalyaminobenzenesulfonamide)thiazole

2-(N4-phthalyaminobenzenesulfonamido)thiazole

2-(N4-phthalylsulfanilamido)thiazole

2-(N4-Phthalylaminobenzenesulfonamide)thiazole

2-(p-N-Phthalylsulfanilyl)aminothiazole

2-(p-Phthalylaminobenzenesulfamido)thiazole

2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]-benzoicaci

4'-(2-Thiazolylsulfamoyl)phthalanilic acid

Talidine

Taloudron

Thalazole

Thalinil

Thalistanin

Thalistatyl

Ultratiazol

Anti-ST8SIA4 antibody produced in rabbit

MGC34450

MGC61459

ST8SIA4

Anti-MGC34450

Anti-MGC61459

Anti-PST

Anti-PST1

Anti-ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 4

Anti-HAST1/HAST2

Anti-MGC5163

Anti-ST1A3

Anti-STP1

Anti-sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

N4-PHTHALYLSULFATHIAZOLE VETRANAL, 250

PHTHALYLSULFATHIAZOLE(PST)

PhthalylsulphathiazolePhthalylsulphathiazoleBp

2-((4-(N-(Thiazol-2-yl)sulfaMoyl)phenyl)carbaMoyl)benzoic acid

Phthalyslsulfathiazole(PST)

N4-Phthalylsul

4-(1,3-dioxo-2-isoindolyl)-N-(2-thiazolyl)benzenesulfonamide