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Phthalylsulfathiazole

Product Name
Phthalylsulfathiazole
CAS No.
85-73-4
Chemical Name
Phthalylsulfathiazole
Synonyms
PST;ST8SIA4;Talidine;Thalinil;MGC34450;MGC61459;Anti-PST;Ftalazol;Taloudron;Thalazole
CBNumber
CB2405964
Molecular Formula
C17H13N3O5S2
Formula Weight
403.43
MOL File
85-73-4.mol
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Phthalylsulfathiazole Property

Melting point:
198-204°C
Boiling point:
371.31℃[at 101 325 Pa]
Density 
1.4235 (rough estimate)
vapor pressure 
0Pa at 25℃
refractive index 
1.6390 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Practically insoluble in water, freely soluble in dimethylformamide, slightly soluble in acetone and in ethanol (96 per cent).
pka
3.40±0.36(Predicted)
color 
White to Light Yellow
Water Solubility 
400mg/L at 28℃
Merck 
14,7377
BRN 
359901
LogP
-2 at 28℃
CAS DataBase Reference
85-73-4(CAS DataBase Reference)
NIST Chemistry Reference
Phthalylsulfathiazole(85-73-4)
EPA Substance Registry System
Benzoic acid, 2-[[[4-[(2-thiazolylamino)sulfonyl]phenyl]amino]carbonyl]- (85-73-4)
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Safety

Safety Statements 
24/25
RIDADR 
3249
RTECS 
TH8575000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29350090
Toxicity
LD50 i.p. in mice: 920 mg/kg (Mattis)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
WH0006817M1
Product name
Monoclonal Anti-SULT1A1 antibody produced in mouse
Purity
clone 1F8, ascites fluid
Packaging
200μL
Price
$524
Updated
2024/03/01
Sigma-Aldrich
Product number
P1500000
Product name
Phthalylsulfathiazole
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
p1500000
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
HPA053995
Product name
Anti-ST8SIA4 antibody produced in rabbit
Purity
Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody
Packaging
100μL
Price
$580
Updated
2024/03/01
Sigma-Aldrich
Product number
HPA051126
Product name
Anti-ST8SIA4 antibody produced in rabbit
Purity
Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging
100μL
Price
$580
Updated
2024/03/01
Sigma-Aldrich
Product number
HPA049500
Product name
Anti-SULT1A1 antibody produced in rabbit
Purity
Prestige Antibodies? Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Packaging
100μL
Price
$547
Updated
2024/03/01
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Phthalylsulfathiazole Chemical Properties,Usage,Production

Chemical Properties

White or yellowish-white, crystalline powder.

Originator

Sulfathalidine, MSD, US,1946

Uses

Phthalylsulfathiazole is a sulfonamide antibacterial drug with similar and stronger effects than Sulfaguanidine and Succinylsulfathiazole. It is rarely absorbed orally and slowly decomposes in the intestine to release Sulfathiazole and exert intestinal antibacterial effects, and is used in the treatment of dysentery, colitis, and gastroenteritis.

Definition

ChEBI: Phthalylsulfathiazole is a sulfonamide incorporating 2-carboxybenzamido and 1,3-thiazol-2-yl moieties that is a broad-spectrum antibiotic indicated in the treatment of dysentery, colitis, gastroenteritis and intestinal surgery. It is a sulfonamide, a member of 1,3-thiazoles, a dicarboxylic acid monoamide and a sulfonamide antibiotic. It derives from a phthalic acid.

Preparation

It may be prepared by the interaction of sulfathiazole and phthalic anhydride in equimolar proportions.
It exerts its bacteriostatic effect in the gastro-intestinal tract. It has been found to be twice as active as sulfaguanidine in the treatment of bowel irregularities. It is often effective in watery diarrhoeas and ulcerative colitis. It is also used in the pre-operative treatment of patients undergoing surgery of the intestinal tract. It may also be recommended in the treatment of acute bascillary dysentry of the Sonne, Flexner and Shiga species.

Manufacturing Process

5 g of phthalic anhydride was added to a boiling suspension of 10 g of sulfathiazole in 100 cc of alcohol. The mixture was then refluxed for 5 minutes after the addition was complete at which time all of the solids were in solution. The solution was then cooled and diluted with an equal volume of water, The white solid precipitate which formed was filtered and recrystallized from dilute alcohol, yielding 2-N4-phthalylsulfanilamidothiazole,which decomposes above 260°C, according to US Patent 2,324,015.

brand name

Canidis-anti-diarr;Carbidiar;Carbotalin;Colicitina;Coliclase;Crematalil;Diacolin;Direver;Disenterol;Ef-micin;Enterocalme;Entero-hermes;Entero-red;Enterosteril;Entero-toxan;Esteraplidin mag;Eugeniteed;Fitazil;Ftalil-tiazol;Ilentazol;Inrestibla strepto;Iodentero-neomicina;Logical;Massotalil;Neo-sulfazon;Novosulfina;Phtazol;Septiftalil;Syptan;Talisulfazol;Tamil;.

Therapeutic Function

Antibacterial (intestinal)

World Health Organization (WHO)

Phthalylsulfathiazole, a sulfonamide anti-infective agent, was introduced in 1946 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. Although phthalylsulfathiazole, which is poorly absorbed from the gastrointestinal tract, is no longer recommended in some countries, it continues to be used in others for the treatment of local intestinal infections, including bacterial dysentery, and for pre-operative bowel preparation.

Flammability and Explosibility

Non flammable

Mode of action

Phthalylsulfathiazole is of low inherent toxicity. Besides, it also enjoys an additional plus point for being only slightly absorbed by the intestinal mucosa ; and, therefore, may be safely administered in comparatively large doses in the management and treatment of bacillary infections of the intestine. The drug is not absorbed orally and is mostly employed for ulcerative colitis.

Phthalylsulfathiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Phthalylsulfathiazole manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Phthalylsulfathiazole 85-73-4
Price
US $95.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
1T
Release date
2021-06-04
Hebei Zhanyao Biotechnology Co. Ltd
Product
Phthalylsulfathiazole 85-73-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2022-01-25
Qiuxian Baitai New Material Co., LTD
Product
Phthalylsulfathiazole 85-73-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000pcs
Release date
2021-03-22

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