7-(Trifluoromethyl)indoline-2,3-dione

Product Name: 7-(Trifluoromethyl)indoline-2,3-dione
CAS No.: 391-12-8
Chemical Name: 7-(Trifluoromethyl)indoline-2,3-dione
Synonyms: 7-(TRIFLUOROMETHYL)ISATIN;7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE;7-TRIFLUOROMET;7-Trifluoroisatin;BUTTPARK 24\07-40;7-TRIFLUOROMETHYLINDOLE;7-(Trifluoromethyl)isatin 98%;7-(Trifluoromethyl)isatin,97%;1,4,7-trifluoroindole-2,3-dione;7-(trifluoromethyl)indole-2,3-dione
CBNumber: CB2406138
Molecular Formula: C9H4F3NO2
Formula Weight: 215.13
MOL File: 391-12-8.mol

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7-(Trifluoromethyl)indoline-2,3-dione Property

Melting point:: 192-193
Density: 1.525±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.43±0.20(Predicted)
color: Very Dark Yellow to Brown
InChI: InChI=1S/C9H4F3NO2/c10-9(11,12)5-3-1-2-4-6(5)13-8(15)7(4)14/h1-3H,(H,13,14,15)
InChIKey: MXLDJTXXAYVWDF-UHFFFAOYSA-N
SMILES: N1C2=C(C=CC=C2C(F)(F)F)C(=O)C1=O
CAS DataBase Reference: 391-12-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36-52
Safety Statements: 26
HazardClass: IRRITANT
HS Code: 2933790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: T2457
Product name: 7-(Trifluoromethyl)isatin
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $20
Updated: 2025/07/31

TCI Chemical

Product number: T2457
Product name: 7-(Trifluoromethyl)isatin
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $64
Updated: 2025/07/31

TRC

Product number: T791300
Product name: 7-(Trifluoromethyl)1H-indole-2,3-dione
Packaging: 10g
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: PC1776
Product name: 7-(Trifluoromethyl)isatin
Purity: 98%
Packaging: 5g
Price: $53
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H17-3-17
Product name: 7-(Trifluoromethyl)isatin
Purity: 98%
Packaging: 5G
Price: $85
Updated: 2021/12/16

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7-(Trifluoromethyl)indoline-2,3-dione Chemical Properties,Usage,Production

Chemical Properties

7-(Trifluoromethyl)indoline-2,3-dione is Brown Solid

Uses

7-(Trifluoromethyl)indoline-2,3-dione is an indole derivative as inhibitor of COX-1, COX-2, and ?catenin.Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer disease.

Uses

An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer''s disease.

Synthesis

444-93-9

391-12-8

General procedure: Concentrated sulfuric acid (95 mL) was preheated in a thermostatic flask at 60 °C. Intermediate 2 ((2E)-2-(hydroxyimino)-N-[2-(trifluoromethyl)phenyl]acetamide, 12 g, 52 mmol) was added slowly in batches while keeping the reaction temperature below 70 °C. Subsequently, the temperature of the reaction system was raised to 80°C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by slow pouring into crushed ice under vigorous stirring. The precipitated solid precipitate was collected by filtration and dried in a vacuum drying oven to give the final product 3 (7-(trifluoromethyl)dihydroindole-2,3-dione).

References

[1] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1248 - 1251
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 1, p. 22 - 26
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 6003 - 6017

7-(Trifluoromethyl)indoline-2,3-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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7-(Trifluoromethyl)indoline-2,3-dione Suppliers

Canada 1 China 140 India 4 Japan 2 Ukraine 2 United Kingdom 7 United States 20 Global 176

Hebei duofang Technology Co. , Ltd.

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Tetranov Biopharm

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Accela ChemBio Co.,Ltd.

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View Lastest Price from 7-(Trifluoromethyl)indoline-2,3-dione manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 7-(Trifluoromethyl)indoline-2,3-dione 391-12-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-25

Shaanxi Dideu Medichem Co. Ltd

Product: 7-(Trifluoromethyl)indoline-2,3-dione 391-12-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-06-25

Henan Fengda Chemical Co., Ltd

Product: 7-(Trifluoromethyl)indoline-2,3-dione 391-12-8
Price: US $36.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-09

391-12-8, 7-(Trifluoromethyl)indoline-2,3-dioneRelated Search:

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7-TRIFLUOROMETHYLINDOLE

7-(TRIFLUOROMETHYL)INDOLINE-2,3-DIONE

7-(TRIFLUOROMETHYL)ISATIN

7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE

7-(trifluoromethyl)indole-2,3-dione

7-(Trifluoromethyl)indoline-2,3-dione 98%

7-(Trifluoromethyl)indoline-2,3-dione98%

BUTTPARK 24\07-40

7-Trifluoroisatin

7-TRIFLUOROMET

7-(trifluoroMethyl)-2,3-dihydro-1H-indole-2,3-dione

7-(Trifluoromethyl)indoline-2,3-dione, 7-(Trifluoromethyl)-1H-indole-2,3-dione

7-(Trifluoromethyl)isatin 98%

1,4,7-trifluoroindole-2,3-dione

1H-Indole-2,3-dione, 7-(trifluoromethyl)-

7-(Trifluoromethyl)-2,3-indolinedione

7-(Trifluoromethyl)indoline-2,3-dione ISO 9001：2015 REACH

7-(Trifluoromethyl)isatin,97%

7-(Trifluoromethyl)-1H-indol-2,3-dione

391-12-8

Heterocyclic Compounds

blocks

IndolesOxindoles

All Inhibitors

Indoles

Simple Indoles

Inhibitors

Intermediates & Fine Chemicals

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