Ascomycin
- Product Name
- Ascomycin
- CAS No.
- 104987-12-4
- Chemical Name
- Ascomycin
- Synonyms
- AAG;IMMUNOMYCIN;AscoMycin solution;Tacrolimus USP Related Compound A;CBR02;FK-520;FR 520;C058028;CS-1818;L 683590
- CBNumber
- CB2406330
- Molecular Formula
- C43H69NO12
- Formula Weight
- 792.01
- MOL File
- 104987-12-4.mol
Ascomycin Property
- Melting point:
- 153-157°C
- Boiling point:
- 868℃
- Density
- 1.19±0.1 g/cm3(Predicted)
- Flash point:
- >110°(230°F)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- ≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
- form
- Powder
- pka
- 9.97±0.70(Predicted)
- Water Solubility
- Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
- InChIKey
- ZDQSOHOQTUFQEM-AMASXYNMSA-N
Safety
- Hazard Codes
- Xn,F
- Risk Statements
- 20/21/22-36-11
- Safety Statements
- 36/37-16
- RIDADR
- UN 1648 3 / PGII
- WGK Germany
- 3
- RTECS
- KD4185000
- F
- 10
- HS Code
- 29419090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H302Harmful if swallowed
H312Harmful in contact with skin
H319Causes serious eye irritation
H332Harmful if inhaled
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
N-Bromosuccinimide Price
- Product number
- A3835
- Product name
- Ascomycin from Streptomyces hygroscopicus var. ascomyceticus
- Packaging
- 1mg
- Price
- $274
- Updated
- 2024/03/01
- Product number
- A-094
- Product name
- Ascomycin solution
- Purity
- 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
- Packaging
- 1mL
- Price
- $288
- Updated
- 2024/03/01
- Product number
- A-094
- Product name
- Ascomycin solution
- Purity
- 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material
- Packaging
- 094-1ml
- Price
- $220
- Updated
- 2021/12/16
- Product number
- J66751
- Product name
- Ascomycin, 95%
- Packaging
- 25mg
- Price
- $180
- Updated
- 2024/03/01
- Product number
- J66751
- Product name
- Ascomycin, 95%
- Packaging
- 100mg
- Price
- $543
- Updated
- 2024/03/01
Ascomycin Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases
Uses
Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.
Uses
Ascomycin is a macrocyclic lactone closely related to tacrolimus and rapamycin. Ascomycin is isolated from several species of Streptomyces and was first reported in 1988. Ascomycin exhibits limited, potent antifungal activity but has found considerable utility as an immunosuppressant.
Definition
ChEBI: A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.
Biological Activity
ascomycin (fk 520, fr900520) is a novel neutral macrolide immunosuppressant, isolated from the cultured broth of streptomyces hygroscopicus subsp. yakushimaensis no. 7238.
in vitro
ascomycin (fk 520, fr900520) suppressed lymphocyte reaction in a dose dependent fashion. ascomycin was non-toxic at concentrations less than 3,200 nm, at which the percent inhibition was 18.9%. ascomycin showed antifungal activity against aspergillus fumigatus ifo 5840. ascomycin had no inhibitory effect on bacteria or yeast at 100 μg/ml [1].
in vivo
ascomycin was dose-dependently effective and clearly prolonged skin allograft survival at 3.2 mg/kg or more, though all skin allografts were rejected within 7 days in rats treated intramuscularly with olive oil. ascomycin, dissolved in olive oil, showed no adverse effect when administered intraperitoneally to ddy mice (male, 8 weeks old) at 100 mg/kg [1].
target
peptidyl-prolyl cis-trans isomerase
storage
-20°C
References
[1] hatanaka h, kino t, miyata s, inamura n, kuroda a, goto t, tanaka h, okuhara m. fr-900520 and fr-900523, novel immunosuppressants isolated from a streptomyces. ii. fermentation, isolation and physico-chemical and biological characteristics. j antibiot (tokyo). 1988;41(11):1592-601.
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View Lastest Price from Ascomycin manufacturers
- Product
- Ascomycin 104987-12-4
- Price
- US $10.00-100.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000 Metric Ton/Month
- Release date
- 2024-01-17
- Product
- Ascomycin 104987-12-4
- Price
- US $8.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28
- Product
- Ascomycin 104987-12-4
- Price
- US $0.00/G
- Min. Order
- 100G
- Purity
- 98%min
- Supply Ability
- 30kg/month
- Release date
- 2023-02-06