Ascomycin

Product Name: Ascomycin
CAS No.: 104987-12-4
Chemical Name: Ascomycin
Synonyms: AAG;IMMUNOMYCIN;AscoMycin solution;Tacrolimus USP Related Compound A;CBR02;FK-520;FR 520;C058028;CS-1818;L 683590
CBNumber: CB2406330
Molecular Formula: C43H69NO12
Formula Weight: 792.01
MOL File: 104987-12-4.mol

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Ascomycin Property

Melting point:: 153-157°C
Boiling point:: 868℃
Density: 1.19±0.1 g/cm3(Predicted)
Flash point:: >110°(230°F)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: ≥38.9 mg/mL in DMSO; insoluble in H2O; ≥98.6 mg/mL in EtOH
form: Powder
pka: 9.97±0.70(Predicted)
color: White to off-white
Water Solubility: Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
InChIKey: ZDQSOHOQTUFQEM-AMASXYNMSA-N

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Safety

Hazard Codes: Xn,F
Risk Statements: 20/21/22-36-11
Safety Statements: 36/37-16
RIDADR: UN 1648 3 / PGII
WGK Germany: 3
RTECS: KD4185000
F: 10
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H312Harmful in contact with skin

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A3835
Product name: Ascomycin from Streptomyces hygroscopicus var. ascomyceticus
Packaging: 1mg
Price: $274
Updated: 2024/03/01

Sigma-Aldrich

Product number: A-094
Product name: Ascomycin solution
Purity: 1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging: 1mL
Price: $288
Updated: 2024/03/01

Sigma-Aldrich

Product number: A-094
Product name: Ascomycin solution
Purity: 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material
Packaging: 094-1ml
Price: $220
Updated: 2021/12/16

Alfa Aesar

Product number: J66751
Product name: Ascomycin, 95%
Packaging: 25mg
Price: $180
Updated: 2024/03/01

Alfa Aesar

Product number: J66751
Product name: Ascomycin, 95%
Packaging: 100mg
Price: $543
Updated: 2024/03/01

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Ascomycin Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases

Uses

Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

Uses

Ascomycin is a macrocyclic lactone closely related to tacrolimus and rapamycin. Ascomycin is isolated from several species of Streptomyces and was first reported in 1988. Ascomycin exhibits limited, potent antifungal activity but has found considerable utility as an immunosuppressant.

Definition

ChEBI: A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.

Biological Activity

ascomycin (fk 520, fr900520) is a novel neutral macrolide immunosuppressant, isolated from the cultured broth of streptomyces hygroscopicus subsp. yakushimaensis no. 7238.

in vitro

ascomycin (fk 520, fr900520) suppressed lymphocyte reaction in a dose dependent fashion. ascomycin was non-toxic at concentrations less than 3,200 nm, at which the percent inhibition was 18.9%. ascomycin showed antifungal activity against aspergillus fumigatus ifo 5840. ascomycin had no inhibitory effect on bacteria or yeast at 100 μg/ml [1].

in vivo

ascomycin was dose-dependently effective and clearly prolonged skin allograft survival at 3.2 mg/kg or more, though all skin allografts were rejected within 7 days in rats treated intramuscularly with olive oil. ascomycin, dissolved in olive oil, showed no adverse effect when administered intraperitoneally to ddy mice (male, 8 weeks old) at 100 mg/kg [1].

target

peptidyl-prolyl cis-trans isomerase

storage

-20°C

References

[1] hatanaka h, kino t, miyata s, inamura n, kuroda a, goto t, tanaka h, okuhara m. fr-900520 and fr-900523, novel immunosuppressants isolated from a streptomyces. ii. fermentation, isolation and physico-chemical and biological characteristics. j antibiot (tokyo). 1988;41(11):1592-601.

Ascomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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Ascomycin Suppliers

Australia 1 Canada 4 China 200 France 1 Germany 7 India 11 Italy 1 Japan 4 Poland 1 Switzerland 3 United Kingdom 8 United States 39 Global 280

CLEANCHEM LABORATORIES LLP

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Maas Pharma Chemicals

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Pharma Affiliates

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Clearsynth Labs

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SynZeal Research Pvt Ltd

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Indogulf Group

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Pharmaffiliates Analytics and Synthetics P. Ltd

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A.J Chemicals

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Country: India
ProdList: 6100
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View Lastest Price from Ascomycin manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Ascomycin 104987-12-4
Price: US $0.00/G
Min. Order: 100G
Purity: 98%min
Supply Ability: 30kg/month
Release date: 2023-02-06

qingdao trust agri chemical co.,ltd

Product: ascomycin 104987-12-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 20tons
Release date: 2024-08-01

Wuhan Xinhao Biotechnology Co., Ltd

Product: Ascomycin 104987-12-4
Price: US $10.00-100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 Metric Ton/Month
Release date: 2024-01-17

104987-12-4, AscomycinRelated Search:

Spiramycin Ascomycin 19-Epi FK-506 8-EpitacroliMus Tacrolimus Hydroxy Acid Impurity Δ23-FK-506 (E/Z)-FK-506 26,28-Allylic Ester RearrangeMent IMpurity Iso-FK-506 (iso-TacroliMus) TacroliMus Methyl Acryl Aldehyde Tacrolimus Open Ring Impurity Tacrolimus Ring-opening Impurity Dihydro-FK506 Paclitaxel Hyodeoxycholic acid Tacrolimus Impurity 7 Tacrolimus Impurity 3 oleandomycin corydalmine

15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-4,10,12,18-tetram

C058028

AscoMycin solution

L 683590, FR 900520, IMMunoMycin, FK 520, WS 7238A, NSC 106410

Ascomycin:Tacrolimus Desmethylene Impurit

Tacrolimus USP RC A

Tacrolimus Imprity 6

Ascomycin:Tacrolimus Desmethylene Impurity

Pimecrolimus 4-Deschloro-4-Hydroxy Impurity

Tacrolimus impurity 2/Tacrolimus Related Compound A(USP)/Ascomycin/(3S,4R,5S, 8R,9E,12S, 14S,15R,16S,18R,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24, 25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-1

TACROLIMUS RELATED COMPOUND A (ASCOMYCIN)

Ascomycin(Immunomycin, FR-900520, FK520)

CS-1818

FK520;FK 520

Ascomycin (Tacrolimus Related Compound A)

Tacrolimus Impurity 5(Ascomycin)（Tacrolimus EP Impurity A）（Tacrolimus USP RC A）

CBR02

Tacrolimus Desmethylene Impurity

AAG

FK-520

FR-900520

IMMUNOMYCIN

ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS

ASCOMYCIN, STREPTOMYCES HYGROSCOPICUS VAR ASCOMYCETICUS

12,18-tetramethyl-,(3s-(3r*(e(1s*,3s*,4s*)),4s*,19s*,26ar*))--10

8-ethyl-3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy

ASCOMYCIN FROM STREPTOMYCESHYGROSCOPICUS VAR ASCOM

Changchuanmycin

FR 520

L 683590

15,19-Epoxy-3H-pyrido2,1-c1,4oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-(1E)-2-(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl-1-methylethenyl-14,16-dimethoxy-4,10,12,18-te

ascomycin from streptomyces hygroscopicus var. ascomyceticus

Ascomycin

Ascorbic acid (tacrolimus-related compound A)

Tacrolimus USP Related Compound A

15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,1...

Tacrolimus EP Impurity A

US-DMF No.: 029433

AscomycinQ: What is Ascomycin Q: What is the CAS Number of Ascomycin Q: What is the storage condition of Ascomycin Q: What are the applications of Ascomycin

ChangChuan drug

TacrolimusUSPRCA/Ascomycin

comycin(FK 520)

AUF4U5NSJK

nagakuamycin

TACROLIMUS EP IMP A

Pimecrolimus 4-Hydroxy Analog

ASCOMYCIN STANDARD

Ascomycin (Tacrolimus EP Impurity A)

Ascomycin impurity A

104987-12-4

104978-12-4

C43H69NO12

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