Ascomycin
- Product Name
- Ascomycin
- CAS No.
- 11011-38-4
- Chemical Name
- Ascomycin
- Synonyms
- AAG;FK-520;CS-740;CGTHBA;Ascomycin;FR-900520;Nsc106410;Aids093221;IMMUNOMYCIN;Aids-093221
- CBNumber
- CB5406331
- Molecular Formula
- C43H69NO12
- Formula Weight
- 792.01
- MOL File
- 11011-38-4.mol
Ascomycin Property
- Melting point:
- 158 - 161°C
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 50 mg/ml), or in Ethanol (up to 50 mg/ml with warming).
- form
- White crystalline solid
- color
- White
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety
- RTECS
- CI7570000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H351Suspected of causing cancer
H361Suspected of damaging fertility or the unborn child
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313IF exposed or concerned: Get medical advice/attention.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SAB2501813
- Product name
- Anti-Nprl3 antibody produced in goat
- Purity
- affinity isolated antibody, buffered aqueous solution
- Packaging
- 100μG
- Price
- $568
- Updated
- 2024/03/01
- Product number
- 182800
- Product name
- Ascomycin, Streptomyces hygroscopicus - CAS 11011-38-4 - Calbiochem
- Purity
- An ethyl analog of FK506 with similar immunosuppressant properties.
- Packaging
- 1mg
- Price
- $205
- Updated
- 2022/05/15
- Product number
- 207066
- Product name
- Ascomycin
- Packaging
- 1mg
- Price
- $273
- Updated
- 2021/12/16
- Product number
- A3698-75
- Product name
- Ascomycin
- Packaging
- 25mg
- Price
- $196
- Updated
- 2021/12/16
- Product number
- orb545956
- Product name
- Ascomycin
- Purity
- >98%
- Packaging
- 25mg
- Price
- $280.5
- Updated
- 2021/12/16
Ascomycin Chemical Properties,Usage,Production
Description
Ascomycin (11011-38-4) is an analog of FK-506 (Cat.# 10-1103). Potent immunosuppressant1. Binds to FKBP122 and inhibits calcineurin and NFAT. Ascomycin displays anti-inflammatory effects in skin diseases3. Cell permeable and active in vivo.
Uses
A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases.
General Description
An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
Biochem/physiol Actions
Product does not compete with ATP.
Enzyme inhibitor
This antifungal antibiotic (FW = 792.02 g/mol; CAS 104987-12-4; Solubility: 50 mM in DMSO), also known as FK520, isolated from Streptomyces hygroscopicus, is also a powerful immunosuppressant. Note that ascomycin is a structural analogue of tacrolimus (or FK506) and, as such, operates by a similar mechanism of action (See Tacrolimus). Ascomycin inhibits allogenic T-lymphocyte proliferation and calcineurin phosphatase activity.
References
1) Hatanaka et al. (1988), FR-900520 and FR-900523, novel immunosuppressants isolated from a Streptomyces. II. Fermentation, isolation and physio-chemical and biological characteristics; J. Antibiot. (Tokyo), 41 1592 2) Petros et al. (1991), NMR studies of an FK506 analogue [U-13C]ascomycin, bound to FKBP: conformation and regions of ascomycin involved in binding; J. Med. Chem., 34 2925 3) Mollison et al. (1999), A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases; J. Invest. Dermatol., 112 729
Ascomycin Preparation Products And Raw materials
Raw materials
Preparation Products
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- 001-857-928-2050 or 1-888-588-9418
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- 001-617-206-9595
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- United States
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View Lastest Price from Ascomycin manufacturers
- Product
- Ascomycin 11011-38-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2024-04-23
- Product
- Ascomycin 11011-38-4
- Price
- US $0.00/KG
- Min. Order
- 100g
- Purity
- 98%+
- Supply Ability
- 100kg
- Release date
- 2020-10-16
- Product
- Ascomycin 11011-38-4
- Price
- US $0.00-0.00/g
- Min. Order
- 100g
- Purity
- 99.5%
- Supply Ability
- 100kg
- Release date
- 2023-07-04