ChemicalBook > CAS DataBase List > 4,6-Dichloro-2-(methylthio)pyrimidine

4,6-Dichloro-2-(methylthio)pyrimidine

Product Name
4,6-Dichloro-2-(methylthio)pyrimidine
CAS No.
6299-25-8
Chemical Name
4,6-Dichloro-2-(methylthio)pyrimidine
Synonyms
NSC 44560;4,6-Dichloro-2-(meth;4,6-DICHLORO-2-(METHYLTHIO)-;Dichloro-2-(Methylthio)pyriM;4,6-Dichloro-2-(Methylthio)Pyr;4,6-Dichloro-2-Methythiopyrimidine;6-Dichloro-2-(Methylthio)pyriMidine;2-Methylthio-4,6-dichloropyrimidine;4,6-DICHLORO-2-THIOMETHYLPYRIMIDINE;4,6-dichloro-dimethylthiopyrimidine
CBNumber
CB2409124
Molecular Formula
C5H4Cl2N2S
Formula Weight
195.07
MOL File
6299-25-8.mol
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4,6-Dichloro-2-(methylthio)pyrimidine Property

Melting point:
38-42 °C(lit.)
Boiling point:
135-136 °C14 mm Hg(lit.)
Density 
1.502 (estimate)
refractive index 
1.6300 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform, Dichloromethane, Ethyl Acetate
pka
-4.86±0.30(Predicted)
form 
Powder or Crystals
color 
White to yellow or orange
BRN 
127664
CAS DataBase Reference
6299-25-8(CAS DataBase Reference)
NIST Chemistry Reference
Pyrimidine, 4,6-dichloro-2-(methylthio)-(6299-25-8)
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Safety

Hazard Codes 
C
Risk Statements 
34-36/37
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
F 
10-19
HazardClass 
8
PackingGroup 
III
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
144533
Product name
4,6-Dichloro-2-(methylthio)pyrimidine
Purity
98%
Packaging
5g
Price
$22.35
Updated
2025/07/31
Sigma-Aldrich
Product number
144533
Product name
4,6-Dichloro-2-(methylthio)pyrimidine
Purity
98%
Packaging
25g
Price
$106
Updated
2025/07/31
TCI Chemical
Product number
D2533
Product name
4,6-Dichloro-2-(methylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
5g
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
D2533
Product name
4,6-Dichloro-2-(methylthio)pyrimidine
Purity
>98.0%(GC)
Packaging
25g
Price
$90
Updated
2025/07/31
TRC
Product number
D435580
Product name
4,6-Dichloro-2-(methylthio)pyrimidine
Packaging
5g
Price
$55
Updated
2021/12/16
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4,6-Dichloro-2-(methylthio)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

4,6-Dichloro-2-(methylthio)pyrimidine (cas# 6299-25-8) is a compound useful in organic synthesis.

General Description

4,6-Dichloro-2-(methylthio)pyrimidine reacts with (η5-C5H5)Fe(CO)2 to form monometallic and bimetallic complexes.

Synthesis

1979-98-2

6299-25-8

Step b: Synthesis of 4,6-dichloro-2-methylthiopyrimidine (19b); 2-methylthiopyrimidine-4,6-diol (30.0 g, 189 mmol) was slowly added to phosphorochloride (350 mL) under cooling in an ice bath, followed by the slow addition of N,N-diethylaniline (52.5 mL) while maintaining cooling. The reaction mixture was gradually warmed to reflux and maintained at reflux for 2.5 hours. Upon completion of the reaction, the mixture was concentrated and subsequently poured into crushed ice for quenching. The aqueous phase was extracted three times with ethyl acetate, and the organic phases were combined and washed sequentially three times with water and once with brine, after which the organic phase was concentrated. The crude product was purified by silica gel column chromatography using hexane-ethyl acetate as eluent to afford 4,6-dichloro-2-methylthiopyrimidine (36 g, 97% yield).

References

[1] Patent: WO2008/95999, 2008, A1. Location in patent: Page/Page column 96
[2] European Journal of Organic Chemistry, 2015, vol. 2015, # 29, p. 6547 - 6556
[3] Organic and Biomolecular Chemistry, 2003, vol. 1, # 19, p. 3353 - 3361
[4] ACS Combinatorial Science, 2014, vol. 16, # 4, p. 168 - 175
[5] Journal of Medicinal Chemistry, 1984, vol. 27, # 12, p. 1621 - 1629

4,6-Dichloro-2-(methylthio)pyrimidine Preparation Products And Raw materials

Raw materials

Thiour Sodium Methoxide

Preparation Products

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4,6-Dichloro-2-(methylthio)pyrimidine Suppliers

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View Lastest Price from 4,6-Dichloro-2-(methylthio)pyrimidine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
4,6-Dichloro-2-(methylthio)pyrimidine 6299-25-8
Price
US $100.00-50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 tons
Release date
2024-11-12
Henan Aochuang Chemical Co.,Ltd.
Product
4,6-Dichloro-2-(methylthio)pyrimidine 6299-25-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Dideu Industries Group Limited
Product
4,6-Dichloro-2-(methylthio)pyrimidine 6299-25-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-14

6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidineRelated Search:

4,6-Dichloropyrimidine 2-Methylsulfonyl-4,6-dimethoxypyrimidine 4,6-Dichloro-2-methylpyrimidine 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE Pyrimidine 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLIC ACID 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXAMIDE 4,6-DICHLORO-2-METHYLTHIO-PYRIMIDINE, [4,6-14C] 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBALDEHYDE 5-PHENYLHYDRAZONE 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBALDEHYDE 5-(2,4-DICHLOROPHENYL)HYDRAZONE, TECH 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBALDEHYDE 5-[3-(TRIFLUOROMETHYL)PHENYL]HYDRAZONE 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBALDEHYDE 5-(2,4-DICHLOROPHENYL)HYDRAZONE 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXALDEHYDE 5-(4-ISOPROPYLPHENYL)HYDRAZONE 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBALDEHYDE 5-(4-ISOPROPYLPHENYL)HYDRAZONE, TECH 5-(([(ANILINOCARBONYL)OXY]IMINO)METHYL)-4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBALDEHYDE 5-PHENYLHYDRAZONE, TECH 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXALDEHYDE 5-PHENYLHYDRAZONE 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXALDEHYDE 5-(2,4-DICHLOROPHENYL)HYDRAZONE

  • 4,6-dichloropyrimidine methyl sulphide
  • 2-Methylthio-4,6-dichloropyrimidine
  • 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE, 9 8%
  • Dichloro-2-methylmercaptopyrimidine,4,6-
  • 4,6-Dichloro-2-(Methylthio)Pyr
  • 4,6-DICHLORO-2-METHYLTHIOPYRIMIDINE 98%
  • 4,6-Dichloro-2-Methythiopyrimidine
  • Pyrimidine, 4,6-dichloro-2-(methylthio)-
  • 4,6-Dichloro-2-(meth
  • 6-Dichloro-2-(Methylthio)pyriMidine
  • 4,6-Dichloro-2-(methylthio)pyrimidine ,99%
  • JR-8367, 4,6-Dichloro-2-(methylthio)pyrimidine, 97%
  • 4,6-Dichloro-2-(Methylthio)pyriMidine, 98% 5GR
  • 2-Methylsulfanyl-4,6-dichloropyriMidine
  • NSC 44560
  • 4,6-DICHLORO-2-THIOMETHYLPYRIMIDINE
  • 4,6-DICHLORO-2-METHYLMERCAPTOPYRIMIDINE
  • 4,6-DICHLORO-2-METHYLSULFANYL-PYRIMIDINE
  • 4,6-DICHLORO-2-(METHYLTHIO)-
  • 4,6-DICHLORO-2-(METHYLTHIO)PYRIMIDINE
  • Dichloro-2-(Methylthio)pyriM
  • 4,6-Dichloro-2-(methylsulphanyl)pyrimidine, 4,6-Dichloro-2-(methylmercapto)-1,3-diazine
  • 4,6- twochloro -2-MethylthiopyriMidine
  • 4,6-dichloro-dimethylthiopyrimidine
  • 4,6-Dichloro-2-(methylthio)pyrimidine&gt
  • 4,6-Dichloro-2-(methylthio)pyrimidine ISO 9001：2015 REACH
  • 6299-25-8 4,6-Dichloro-2-(methylthio)pyrimidine
  • 6299-25-8
  • 6229-25-8
  • C5H4Cl2N2S
  • C5H4N2Cl2S
  • C5H4CI2N2S
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidines
  • Building Blocks
  • Bases & Related Reagents
  • Nucleotides
  • Sulfur & Selenium Compounds
  • Pyrazines, Pyrimidines & Pyridazines
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyrimidines
  • PyrimidinesHeterocyclic Building Blocks
  • Pyrimidine
  • Nucleotides and Nucleosides
  • Halides
  • Pyrazines, Pyrimidines & Pyridazines
  • Heterocycle-Pyrimidine series