(2S)-Bornane-10,2-sultam

Product Name: (2S)-Bornane-10,2-sultam
CAS No.: 108448-77-7
Chemical Name: (2S)-Bornane-10,2-sultam
Synonyms: (7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide;2-sultaM;L-SultaM;(2S)-Bornane-10;L-2,10-amphorsultam;D-(-)-CAMPHOR SULTAM;(2S)-Borne-10,2-sultam;(+)-10,2-CAMPHORSULTAM;(+)-2,10-CAMPHORSULTAM;(1R)-(+)-Camphorsultam
CBNumber: CB2411257
Molecular Formula: C10H17NO2S
Formula Weight: 215.31
MOL File: 108448-77-7.mol

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(2S)-Bornane-10,2-sultam Property

Melting point:: 185-187 °C(lit.)
alpha: 33 º (c=4.9, CHCl3)
Boiling point:: 324.8±25.0 °C(Predicted)
Density: 1.1469 (rough estimate)
refractive index: 31 ° (C=1, CHCl3)
storage temp.: Sealed in dry,Room Temperature
solubility: almost transparency in Chloroform
form: powder to crystal
pka: 11.05±0.40(Predicted)
color: White to Almost white
optical activity: [α]20/D +32°, c = 5 in chloroform
BRN: 4675755
InChI: InChI=1S/C10H17NO2S/c1-9(2)7-3-4-10(9)6-14(12,13)11-8(10)5-7/h7-8,11H,3-6H2,1-2H3/t7-,8-,10-/m0/s1
InChIKey: DPJYJNYYDJOJNO-CFGJQEBVSA-N
SMILES: N1[C@]2([H])[C@@]3(C(C)(C)[C@]([H])(C2)CC3)CS1(=O)=O
CAS DataBase Reference: 108448-77-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C1324
Product name: (+)-10,2-Camphorsultam
Purity: >98.0%(GC)
Packaging: 1g
Price: $94
Updated: 2021/12/16

TCI Chemical

Product number: C1324
Product name: (+)-10,2-Camphorsultam
Purity: >98.0%(GC)
Packaging: 5g
Price: $325
Updated: 2024/03/01

Alfa Aesar

Product number: A14133
Product name: (1R,2S)-(+)-10,2-Camphorsultam, 99%
Packaging: 1g
Price: $75.65
Updated: 2024/03/01

Alfa Aesar

Product number: A14133
Product name: (1R,2S)-(+)-10,2-Camphorsultam, 99%
Packaging: 5g
Price: $237.65
Updated: 2024/03/01

TRC

Product number: C175130
Product name: (1R)-(+)-2,10-Camphorsultam
Packaging: 5g
Price: $140
Updated: 2021/12/16

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(2S)-Bornane-10,2-sultam Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

(1R)-(+)-2,10-Camphorsultam has been used as a reactant in the synthesis of pyrrolidine acid analogs as potent dual PPARα/γ agonists.

Application

(2S)-Bornane-10,2-sultam is a pharmaceutical intermediate compound that can be used to synthesize sulfonamide drugs. (2R)-Bornane-10,2-sultam can be used as a chiral auxiliary to perform intramolecular 1,3-dipolar cycloadditions to generate bridged and fused cycloadditions with complete diastereocontrol. Reduction of fused isoxazolidines can generate 1-azaspiro[4.5]decane, which is a potential intermediate in the asymmetric synthesis of cylindrosin alkaloids^[1].

Purification Methods

The (-)-enantiomer is recrystallised from 95% EtOH and dried in a vacuum desiccator. It dissolves in dilute aqueous NaOH and can be precipitated without hydrolysis by acidifying. It forms the N-Na salt in EtOH (by addition of Na to the EtOH solution), and the salt can be methylated with MeI to give the (-)-N-Me lactam with m 80o after recrystallisation from hot H2O and has []D -59.6o (c 5, CHCl3) [Shriner et al. J Am Chem Soc 60 2794 1938]. [Oppolzer et al. Helv Chim Acta 69 1142 1986, Weismiller et al. Org Synth 69 154 1955, Beilstein 27 III/IV 1007.]

References

[1] MARK C BAGLEY; Wolfgang O. Asymmetric synthesis of 1-azaspiro[4.5]decanes via intramolecular dipolar cycloaddition of nitrones containing the bornane-10,2-sultam chiral auxiliary[J]. Tetrahedron, asymmetry, 2000. DOI:10.1016/S0957-4166(00)00205-6.

(2S)-Bornane-10,2-sultam Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-Bornane-10,2-sultam Suppliers

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View Lastest Price from (2S)-Bornane-10,2-sultam manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: (1R)-(+)-2,10-Camphorsultam 108448-77-7
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20tons
Release date: 2024-08-29

Aromsyn Co., Ltd.

Product: (1R)-(+)-2,10-Camphorsultam 108448-77-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: kgs
Release date: 2023-02-17

Career Henan Chemical Co

Product: (2S)-Bornane-10,2-sultam 108448-77-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20KG
Release date: 2018-08-07

108448-77-7, (2S)-Bornane-10,2-sultamRelated Search:

3-Aminobenzenesulfonamide N,N-Dimethylformamide Dacthal Dimethyl ether Dimethyl sulfoxide Methanesulfonamide Cyclopropanesulfonamide Dimethyl fumarate Sulfanilamide Benzenesulfonamide Dimethyl carbonate ETHANE Dimethyl sulfate Dimethyl phthalate Dimethyl disulfide p-Toluenesulfonamide (2R)-Bornane-10,2-sultam (1S)-(+)-10-CAMPHORSULFONAMIDE

(7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide

(2S)-Borne-10,2-sultam

L-2,10-Camphorsultam,99%e.e.

(2S)-BORNANE-10,2-SULTAM

(1R)-(+)-2,10-CAMPHORSULTAM

(1R)-2,10-CAMPHORSULTAM

(1R,2S)-(+)-2,10-CAMPHORSULTAM

(1R,5S)-10,10-DIMETHYL-3-THIA-4-AZATRICYCLO[5.2.1.01,5]DECANE 3,3-DIOXIDE

(+)-2,10-CAMPHORSULTAM

(+)-10,2-CAMPHORSULTAM

(IR)-(+)-2,10-Camphorsultam

(1R)-(+)-2,10-camphorsultam ,98%

L-2,10-amphorsultam

(2S)-Bornane-10

2-sultaM

(2S)-Bornane-1,2-sultaM

L-SultaM

(2S)-Bornane-10,2-sultam (1R,5S)-10,10-Dimethyl-3-thia-4-azatricyclo[5.2.1.0(1,5)]decane 3,3-Dioxide

(1<i>R</i>)-(+)-2,10-Camphorsultam

(5S,7S)-10,10-dimethyl-3λ-thia-4-azatricyclo[5.2.1.01,]decane-3,3-dione

(2S)-Bornane-10,2-sultam (1R)-(+)-2,10-Camphorsultam

[3AR-(3A-ALPHA,6-ALPHA,7A-BETA)]-HEXAHYDRO-8,8-DIMETHYL-2,2-DIOXIDE-3H-3A,6-METHANO-2,1-BENZISOTHIAZOLE

[3aR-(3aalpha,6alpha,7abeta)]-Hexahydro-8,8-dimethyl-2,2-dioxide-3H-3a,6-methano-2,1-benzisothiazole

(+)-EXO-10,2-BORNANESULTAM

(+)-L-2,10-CAMPHORSULTAM

L(+)-10,2-CAMPHORSULTAME

D-(-)-CAMPHOR SULTAM

(+)-2,10-CAMPHORSULTAM 99%

(2S)-Bornane-10,2-sultam,99+%, (99+% ee)

(2S)-Bornane-10,2-sultam,98%

(+)-exo-10,2-Bornanesultam, (1R,5S)-10,10-Dimethyl-3-thia-4-azatricyclo[5.2.1.01,5]decane 3,3-dioxide

(+)-10,2-Camphorsultam, (+)-exo-10,2-Bornanesultam, L-2,10-Camphorsultam, (1R,5S)-10,10-Dimethyl-3-thia-4-azatricyclo[5.2.1.01,5]decane 3,3-dioxide

(1β,5α,7β)-10,10-Dimethyl-3-thia-4-azatricyclo[5.2.1.01,5]decane3,3-dioxide

(3aR)-1,4,5,6,7,7aβ-Hexahydro-8,8-dimethyl-3H-3aα,6α-methano-2,1-benzisothiazole 2,2-dioxide

(3aR,3aα,6α,7aβ)-8,8-Dimethyl-3a,6-methanooctahydro-2,1-benzisothiazole 2,2-dioxide

[3aR,7aβ,(+)]-Hexahydro-8,8-dimethyl-3H-3aα,6α-methano-2,1-benzisothiazole 2,2-dioxide

(1R)-(+)-Camphorsultam

(1R,2S)-(+)-10,2-Camphorsultam

(1R,2S)-(+)-10,2-CamphorsuL

3H-3a,6-Methano-2,1-benzisothiazole, hexahydro-8,8-dimethyl-, 2,2-dioxide, (3aR,6S,7aS)-

(3aR)-8,8-dimethylhexahydro-2H-3a,6-methanobenzo[d]isothiazole 1,1-dioxide

(2S)-Bornane-10,2-sultam ISO 9001：2015 REACH

(3aR,6S,7aS)-8,8-Dimethylhexahydro-1H-3a,6-methanobenzo[c]isothiazole 2,2-dioxide

(+)-10，2-Camphorsultam

(5S,7S)-10,10-dimethyl-3λ?-thia-4-azatricyclo[5.2.1.01?]decane 3,3-dioxide

(+)-2,10-Camphorsultam

108448-77-7

C10H17NO2S

Sulfur-Based

Sulfur Compounds (for Synthesis)

Bicyclic Monoterpenes

Terpenes

Asymmetric Synthesis

Chiral Auxiliaries

chiral

Asymmetric Synthesis

Bicyclic Monoterpenes

Biochemistry