(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
- Product Name
- (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
- CAS No.
- 160706-62-7
- Chemical Name
- (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
- Synonyms
- D-1-CBZ-NIPECOTIC ACID;(R)-1-Benzyloxycarbonylnipecotic acid;(R)-1-CBZ-3-piperidinecarboxylic acid;(R)-1-CBZ-PIPERIDINE-3-CARBOXYLIC ACID;1-Cbz-(3R)-3-piperidinecarboxylic acid;(R)-1-CBZ-PIPERIDINE-1-CARBOXYLIC ACID;(R)-(+)-N-cbz-3-piperidinecarboxylic acid;3(R)-N-(Carbobenzyloxy)-3-carboxypiperidine;(R)-1-Cbz-piperidine-3-carboxylic acid - [P12343];(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER
- CBNumber
- CB2433479
- Molecular Formula
- C14H17NO4
- Formula Weight
- 263.29
- MOL File
- 160706-62-7.mol
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Property
- Boiling point:
- 443.9±45.0 °C(Predicted)
- Density
- 1.265
- storage temp.
- 2-8°C
- pka
- 4.48±0.20(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B700285
- Product name
- (R)-1-((Benzyloxy)carbonyl)piperidine-3-carboxylicAcid
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 17563
- Product name
- Z-D-nipecoticacid,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 1G
- Price
- $28
- Updated
- 2021/12/16
- Product number
- P12343
- Product name
- (R)-1-Cbz-piperidine-3-carboxylicacid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 074061
- Product name
- (R)-Piperidine-1,3-dicarboxylic acid1-benzyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- W3488
- Product name
- (R)-Piperidine-1,3-dicarboxylicacid1-benzylester
- Packaging
- 1g
- Price
- $83
- Updated
- 2021/12/16
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Chemical Properties,Usage,Production
Synthesis
501-53-1
498-95-3
160706-62-7
GENERAL STEPS: (R)-Piperidine-3-carboxylic acid (XXVII) (5.0 g, 39 mmol) was dissolved in a solvent mixture of 50 mL of THF and 20 mL of water and cooled to 0 °C. Subsequently, sodium bicarbonate (6.5 g, 77.4 mmol) and benzyl chloroformate (8.0 g, 46.4 mmol) were added. The reaction mixture was stirred at 0 °C for 30 min and then continued to stir at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated under reduced pressure. The remaining aqueous phase was extracted with ether to remove unreacted benzyl chloroformate, then the pH was adjusted to 6 with 1 M HCl solution and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give 1-benzyl ester of (R)-piperidine-1,3-dicarboxylic acid (XXVIII) (3.7 g, 36% yield). Mass spectrum (MS): m/z = 263.9 (M + 1). 1H NMR (DMSO-d6) δ = 7.38 (5H, m), 5.12 (2H, s), 4.19-3.90 (2H, m), 3.02 (1H, m), 2.44 (1H, m), 2.05 (1H, m), 1.80-1.40 (3H, m).
References
[1] Patent: WO2009/47359, 2009, A1. Location in patent: Page/Page column 160
[2] European Journal of Medicinal Chemistry, 2012, vol. 54, p. 771 - 783
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
(R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
- Tel
- --
- Fax
- --
- enquiry@sldrugs.com
- Country
- India
- ProdList
- 2683
- Advantage
- 50
View Lastest Price from (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER manufacturers
- Product
- (R)-PIPERIDINE-1,3-DICARBOXYLIC ACID 1-BENZYL ESTER 160706-62-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-20