ChemicalBook > CAS DataBase List > 4-FLUORO-2-HYDROXYBENZALDEHYDE
4-FLUORO-2-HYDROXYBENZALDEHYDE
- Product Name
- 4-FLUORO-2-HYDROXYBENZALDEHYDE
- CAS No.
- 348-28-7
- Chemical Name
- 4-FLUORO-2-HYDROXYBENZALDEHYDE
- Synonyms
- 4-FLUOROSALICYLALDEHYDE;SW-40;SWF-40;4-Fluorosalicyladehyde;4-FLUORO-2-HYDROXYBENZALDEHYDE;2-HYDROXY-4-FLUOROBENZALDEHYDE;Benzaldehyde, 4-fluoro-2-hydroxy-;4-Fluoro-2-hydroxybenzaldehyde ,98%;4-Fluorosalicylaldehyde, 5-Fluoro-2-formylphenol;2-Hydroxy-4-Fluorobenzaldehyde 4-Fluoro Salicylaldehyde
- CBNumber
- CB2437912
- Molecular Formula
- C7H5FO2
- Formula Weight
- 140.11
- MOL File
- 348-28-7.mol
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4-FLUORO-2-HYDROXYBENZALDEHYDE Property
- Melting point:
- 70-72°C
- Boiling point:
- 208.2±20.0 °C(Predicted)
- Density
- 1.350±0.06 g/cm3(Predicted)
- Flash point:
- 110°
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline solid
- pka
- 7.18±0.10(Predicted)
- color
- Pale yellow
- Sensitive
- Air Sensitive
- CAS DataBase Reference
- 348-28-7(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TRC
- Product number
- F596205
- Product name
- 4-Fluorosalicylaldehyde
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2620-3-42
- Product name
- 4-Fluoro-2-hydroxybenzaldehyde
- Purity
- 99%
- Packaging
- 5G
- Price
- $98
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 2620-3-42
- Product name
- 4-Fluoro-2-hydroxybenzaldehyde
- Purity
- 99%
- Packaging
- 1g
- Price
- $24
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 072824
- Product name
- 4-Fluorosalicylaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $160
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- JK540611
- Product name
- 4-Fluoro-2-hydroxybenzaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $222
- Updated
- 2021/12/16
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4-FLUORO-2-HYDROXYBENZALDEHYDE Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
4-Fluorosalicylaldehyde is used as a reagent to synthesize quinoline derivatives that have potential antibacterial and antituberculosis effects. 4-Fluorosalicylaldehyde is also used as a reagent to prepare chromones (e.g. 4-Oxo-4H-1-benzopyran-2-carboxylic acid [B205670]).
Synthesis
50-00-0
372-20-3
348-28-7
The general procedure for the synthesis of 4-fluoro-2-hydroxybenzaldehyde from formaldehyde and 3-fluorophenol was as follows: to a mixture containing 3-fluorophenol (5 mL, 55.3 mmol) and anhydrous acetonitrile (250 mL) were added MgCl2 (14.2 g, 149 mmol), anhydrous trimethylamine (27 mL) and paraformaldehyde (11 g). The reaction mixture was stirred under reflux conditions for 5 h and subsequently cooled to room temperature. The reaction was quenched by addition of 5% hydrochloric acid (250 mL) and extracted with ethyl acetate (100 mL × 3). The combined organic layers were washed sequentially with 5% hydrochloric acid, water and brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 50:1 to 20:1) to afford 4-fluoro-2-hydroxybenzaldehyde (5 g, 65% yield) as a light yellow solid.1H NMR (400 MHz, CDCl3) data were as follows: δ 11.37 (d, J = 1.6 Hz, 1H), 9.83 (s, 1H), 7.55- 7.59 (m, 1H), 6.65-6.75 (m, 2H).
References
[1] Patent: WO2004/87686, 2004, A2. Location in patent: Page 504
[2] Patent: WO2004/87687, 2004, A1. Location in patent: Page 504
[3] Patent: WO2017/55860, 2017, A1. Location in patent: Page/Page column 138-139
[4] Patent: US2017/37038, 2017, A1. Location in patent: Paragraph 0375; 0376; 0377
[5] Patent: KR101679262, 2016, B1. Location in patent: Paragraph 0156-0158
4-FLUORO-2-HYDROXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-FLUORO-2-HYDROXYBENZALDEHYDE manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-FLUORO-2-HYDROXYBENZALDEHYDE 348-28-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-25
Shaanxi Dideu Medichem Co. Ltd
- Product
- 4-Fluoro-2-hydroxybenzaldehyde 348-28-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-15
Career Henan Chemical Co
- Product
- 4-FLUORO-2-HYDROXYBENZALDEHYDE 348-28-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-30
348-28-7, 4-FLUORO-2-HYDROXYBENZALDEHYDERelated Search:
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