ChemicalBook > CAS DataBase List > (R)-(+)-4-HYDROXY-2-PYRROLIDINONE

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE

Product Name
(R)-(+)-4-HYDROXY-2-PYRROLIDINONE
CAS No.
22677-21-0
Chemical Name
(R)-(+)-4-HYDROXY-2-PYRROLIDINONE
Synonyms
RHPD;In1122 Impurity 78;Oxiracetam Impurity P;(R)-4-hydoroxyoyrolidone;4-hydroxy-R-2-pyrrolidine;(R)-4-HYDROXY-2-PYRROLIDONE;(r)-β-hydroxy-γ-butyrolactam;（R)+4-hydroxy-2-prrolidinone;(R)-4-hydroxy-2-pyrrolidione;(4R)-4-hydroxy-2-pyrrolidone
CBNumber
CB2438434
Molecular Formula
C4H7NO2
Formula Weight
101.1
MOL File
22677-21-0.mol
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(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Property

Melting point:
156-160 °C
Boiling point:
363.6±35.0 °C(Predicted)
Density 
1.292±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Sparingly), Methanol (Slightly), Water (Sparingly)
pka
13.62±0.20(Predicted)
form 
Powder
color 
White to pale yellow
optical activity
[α]23/D +43°, c = 1 in ethanol
Water Solubility 
Slightly soluble in water.
BRN 
1524193
InChI
InChI=1S/C4H7NO2/c6-3-1-4(7)5-2-3/h3,6H,1-2H2,(H,5,7)/t3-/m1/s1
InChIKey
IOGISYQVOGVIEU-GSVOUGTGSA-N
SMILES
N1C[C@H](O)CC1=O
CAS DataBase Reference
22677-21-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-38-37-36
Safety Statements 
26
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
479160
Product name
(R)-(+)-4-Hydroxy-2-pyrrolidinone
Purity
97%
Packaging
1g
Price
$114
Updated
2025/07/31
Sigma-Aldrich
Product number
479160
Product name
(R)-(+)-4-Hydroxy-2-pyrrolidinone
Purity
97%
Packaging
5g
Price
$417
Updated
2023/06/20
TRC
Product number
H953070
Product name
(R)-(+)-4-Hydroxy-2-pyrrolidinone
Packaging
1g
Price
$1110
Updated
2021/12/16
ChemScene
Product number
CS-W013709
Product name
(R)-4-Hydroxypyrrolidin-2-one
Purity
>98.0%
Packaging
100g
Price
$1492
Updated
2021/12/16
ChemScene
Product number
CS-W013709
Product name
(R)-4-Hydroxypyrrolidin-2-one
Purity
>98.0%
Packaging
25g
Price
$521
Updated
2021/12/16
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(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

The (R)-enantiomer intermediate in the preparation of Oxiracetam

Uses

(R)-(+)-4-Hydroxy-2-pyrrolidinone intermediate in the preparation of Oxiracetam. Also used as enantiomeric intermediate for the asymmetric single isomeric drugs including antitumor, anesthetic, antipasmodic, anti-inflammatory or anti-HIV activity products.

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-4-HYDROXY-2-PYRROLIDINONE Suppliers

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View Lastest Price from (R)-(+)-4-HYDROXY-2-PYRROLIDINONE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
(R)-(+)-4-Hydroxy-2-pyrrolidinone 22677-21-0
Price
US $3.00-9.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2025-06-24
Career Henan Chemical Co
Product
(R)-(+)-4-HYDROXY-2-PYRROLIDINONE 22677-21-0
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

22677-21-0, (R)-(+)-4-HYDROXY-2-PYRROLIDINONERelated Search:

(R)-(+)-4-HYDROXY-2-PYRROLIDINONE (3R,4R)-1-Benzyl-3,4-dihydroxypyrrolidine-2,5-dione (S)-(+)-4-HYDROXY-2-PYRROLIDINONE,(S)-4-HYDROXY-2-PYRROLIDINONE,(S)-(-)-4-HYDROXY-2-PYRROLIDINONE 4-Hydroxy-2-pyrrolidinone (S)-(-)-3-hydroxy-2-pyrrolidinone (S)-(-)-3-AMINO-1-HYDROXYPYRROLIDIN-2-ONE 3-HYDROXY-2-PYRROLIDINONE (S)-1-BENZYL-4-HYDROXY-2-PYRROLIDINONE ALPHA-PYRIDOIN (R)-(+)-1-BENZYL-4-HYDROXY-2-PYRROLIDINONE,(R)-1-BENZYL-4-HYDROXY-2-PYRROLIDINONE 3-CYCLOPENTYL-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID (3R,4S)-1-BENZYL-3,4-DIHYDROXY-2,5-PYRROLIDINEDIONE 4-OXO-3-PHENETHYL-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID (+)-TARTRANIL 3-(2-DIETHYLAMINO-ETHYL)-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID 3-(3-METHOXY-PROPYL)-4-OXO-10-OXA-3-AZA-TRICYCLO[5.2.1.0(1,5)]DEC-8-ENE-6-CARBOXYLIC ACID (S)-4-HYDROXY-2-PYRROLIDINONE-1-N-ACETIC ACID R(+)-3-AMINO-1-HYDROXY-2-PYRROLIDINONE

  • (R)-(+)-4-HYDROXY-2-PYRROLIDINONE
  • (R)-4-HYDROXY-2-PYRROLIDINONE
  • (R)-4-HYDROXY-2-PYRROLIDONE
  • (R)-BETA-HYDROXY-GAMMA-BUTYROLACTAM
  • RHPD
  • 2-PYRROLIDINONE, 4-HYDROXY-, (R)
  • 4-hydroxy-R-2-pyrrolidine
  • (r)-(+)-β-hydroxy-γ-butyrolactam
  • (r)-β-hydroxy-γ-butyrolactam
  • 2-Pyrrolidinone, 4-hydroxy-, (4R)-
  • (R)-4-hydoroxyoyrolidone
  • （R)+4-hydroxy-2-prrolidinone
  • (R)-4-Hydroxy-pyrrolidin-2-one
  • (4R)-4-Hydroxypyrrolidine-2-one
  • (R)-4β-Hydroxypyrrolidine-2-one
  • [4R,(-)]-4-Hydroxypyrrolidin-2-one
  • (R)-4-hydroxy-2-pyrrolidione
  • (4R)-4-hydroxy-2-pyrrolidone
  • (4R)-4-Hydroxy-2-pyrrolidinone
  • In1122 Impurity 78
  • Oxiracetam Impurity P
  • (R)-(+)-4-Hydroxy-2-pyrrolidinone, 97%,
  • (<i>R</i>)-(+)-4-Hydroxy-2-pyrrolidinone
  • (R)-4-hydroxypyrrolidin-2-one, 98%min
  • 22677-21-0
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Heterocyclic Building Blocks
  • Pyrrolidines
  • Pyrrole&Pyrrolidine&Pyrroline
  • Amines
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Drug Intermediates