Tolclofos-methyl
- Product Name
- Tolclofos-methyl
- CAS No.
- 57018-04-9
- Chemical Name
- Tolclofos-methyl
- Synonyms
- S-3349;RIZOLEX;Basilex;Risolex;Risolex(TM);Tolcofos-methyl;olclofos-methyl;Methyl tolclofo;TOLCLOFOS-METHYL;Methyl tolclofos
- CBNumber
- CB2451996
- Molecular Formula
- C9H11Cl2O3PS
- Formula Weight
- 301.13
- MOL File
- 57018-04-9.mol
Tolclofos-methyl Property
- Melting point:
- 78-80°C
- Boiling point:
- 338.5±52.0 °C(Predicted)
- Density
- 1.401±0.06 g/cm3(Predicted)
- vapor pressure
- 1.84 x 10-3 (Pa 25 °C)
- Flash point:
- >100 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- form
- Solid
- Water Solubility
- 1.10 mg l-1 (25 °C)
- color
- White to off-white
- Merck
- 13,9587
- BRN
- 2136521
- InChIKey
- OBZIQQJJIKNWNO-UHFFFAOYSA-N
- LogP
- 4.560
- CAS DataBase Reference
- 57018-04-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Phosphorothioic acid, o-(2,6-dichloro-4-methylphenyl) o,o-dimethyl ester(57018-04-9)
- EPA Substance Registry System
- Tolclofos-methyl (57018-04-9)
Safety
- Hazard Codes
- Xi,N
- Risk Statements
- 43-50/53
- Safety Statements
- 22-24/25-61-60-37-24
- RIDADR
- UN 3077 9 / PGIII
- WGK Germany
- 3
- RTECS
- TF0460000
- HS Code
- 29201900
- Hazardous Substances Data
- 57018-04-9(Hazardous Substances Data)
- Toxicity
- LD50 in male, female rats, male, female mice (mg/kg): ~5000, ~5000, 3500, 3600 orally; all >5000 dermally; ~5000, 4900, 1070, 1260 i.p.; all >5000 s.c. (Ohtsuki, Fujinami)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 31209
- Product name
- Tolclofos-methyl
- Purity
- PESTANAL
- Packaging
- 250mg
- Price
- $49.56
- Updated
- 2024/03/01
- Product number
- T535265
- Product name
- Tolclofos-methyl
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- CS-5201
- Product name
- Tolclofos-methyl
- Purity
- 96.51%
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- PST0000303
- Product name
- TOLCLOFOS-METHYL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.25
- Updated
- 2021/12/16
- Product number
- 99597
- Product name
- Tolclofos-methyl
- Packaging
- 1g
- Price
- $575
- Updated
- 2021/12/16
Tolclofos-methyl Chemical Properties,Usage,Production
Uses
Tolclofos-methyl is a non-systemic organophosphorus fungicide with both protective and curative activities that control soil-borne diseases caused by Rhizoctonia solani, Corticium rolfsii, Tphula incamata and Typhula ishikariensis in/on potatoes, sugar beet, cotton and peanuts.
Uses
Agricultural fungicide.
Definition
ChEBI: An organic thiophosphate that is 2,6-dichloro-4-methylphenol in which the hydrogen of the hydroxy group group has been replaced by a dimethoxyphosphorothioyl group. Tolclofos-methyl is a phospholipid biosynthesis inhibitor and fungicide that is used for co trolling soil-borne diseases caused by Typhula incarnata, Corticium rolfsii, Typhula ishikariensis, and Rhizoctonia solani.
Metabolic pathway
Tolclofos-methyl underwent common degradation and metabolic pathways in water, soil, plants and animals. These reactions are well documented for most organophosphorus compounds and include oxidative desulfuration, hydroxylation/oxidation of the 4-methyl group to the alcohol and carboxylic acid, cleavage of the P-O-aryl linkage, O-demethylation and conjugation. In addition to the above reactions, photolytic isomerisation to the thionate (P=S) was also observed. A schematic presentation of the primary metabolic pathways for tolclofosmethyl is illustrated in Scheme 1.
Degradation
[14C-phenyl]Tolclofos-methyl(1) was stable to hydrolytic degradation at
pH 5, 7 and 9 at 22°C with DT50 values of 139, 417 and 238 days,
respectively. Higher temperature led to a more rapid hydrolysis and two
hydrolysis products were detected. O-Demethylation and oxidative desulfuration
were the major reactions to yield 2,6-dichloro-p-tolyl methyl
hydrogen phosphorothioate (2) and toclofos-methyl oxon (O-2,6-dichlorop-
tolyl O,O-dimethyl phosphate, 3), respectively. Cleavage of the P-O-aryl
linkage yielded 2,6-dichloro-4-methylphenol(4) as a minor degradation
product (WHO, 1994).
Tolclofos-methyl degraded in water under natural sunlight irradiation
with DT50 values of 44 days (in distilled water), 15-28 days (in natural
river and pond water) and less than 2 days in 2% acetone/water. The
major degradation reactions included oxidative desulfuration to yield
compound 3 and O-demethylation to yield compound 2. The major
photodegradation products in river and pond waters and soil thinlayer
surfaces were compounds 2, 3, 4 and the O-demethylated 3 (2,6-
dichloro-p-tolyl methyl hydrogen phosphate, 5) (Mikami et al., 1984).
In acetone solution, demethylation of the isomerisation product [2,6-
dichloro-p-tolyl O,S-dimethyl phosphorothioate (6)] yielded 2,6-dichlorop-
tolyl S-methyl hydrogen phosphorothioate (7) and 2,6-dichloro-p-tolyl
dihydrogen phosphate (8) as the major photodegradates (Mikami et al.,
1984).
Toxicity evaluation
Its acute oral toxicity is very low in comparison with a thio-ester type of other organophosphorus fungicides (edifenphos, iprobenfos, and pyrazophos).
Tolclofos-methyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tolclofos-methyl manufacturers
- Product
- Tolclofos-methyl 57018-04-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-29