ChemicalBook > CAS DataBase List > SCOPOLAMINE METHYL NITRATE

SCOPOLAMINE METHYL NITRATE

Product Name
SCOPOLAMINE METHYL NITRATE
CAS No.
6106-46-3
Chemical Name
SCOPOLAMINE METHYL NITRATE
Synonyms
skopyl;viscope;mescomine;skopolate;itrate,(-)-tropate;HYOSCINEMETHONITRATE;Scopolamine (nitrate);dwithmethylnitrate1:1);HYOSCINE METHYL NITRATE;METHSCOPOLAMINE NITRATE
CBNumber
CB2453455
Molecular Formula
C18H24N2O7
Formula Weight
380.4
MOL File
6106-46-3.mol
More
Less

SCOPOLAMINE METHYL NITRATE Property

Melting point:
199 °C
refractive index 
-25 ° (C=1, H2O)
Water Solubility 
almost transparency in Water
form 
powder to crystal
color 
White to Almost white
Merck 
14,8406
CAS DataBase Reference
6106-46-3(CAS DataBase Reference)
EPA Substance Registry System
Methylscopolamine nitrate (6106-46-3)
More
Less

Safety

Hazard Codes 
T,T+
Risk Statements 
23/24/25-26/27/28
Safety Statements 
36/37/39-45-25
RIDADR 
UN 1544 6.1/PG 3
WGK Germany 
3
RTECS 
YM3675150
HS Code 
2939.80.0000
HazardClass 
6.1
PackingGroup 
III
Hazardous Substances Data
6106-46-3(Hazardous Substances Data)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P262Do not get in eyes, on skin, or on clothing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P310Immediately call a POISON CENTER or doctor/physician.

P320Specific treatment is urgent (see … on this label).

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
S0230
Product name
Scopolamine Methyl Nitrate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$158
Updated
2024/03/01
TCI Chemical
Product number
S0230
Product name
Scopolamine Methyl Nitrate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$512
Updated
2024/03/01
TRC
Product number
S200068
Product name
(-)ScopolamineMethylnitrate
Packaging
100mg
Price
$45
Updated
2021/12/16
Chem-Impex
Product number
32523
Product name
Scopolaminemethylnitrate,99%(Assaybytitration,HPLC)
Purity
99%(Assaybytitration,HPLC)
Packaging
1G
Price
$72.8
Updated
2021/12/16
Chem-Impex
Product number
32523
Product name
Scopolaminemethylnitrate,≥99%(Assaybytitration,HPLC)Hazmat
Purity
≥99%(Assaybytitration,HPLC)
Packaging
5G
Price
$262.08
Updated
2021/12/16
More
Less

SCOPOLAMINE METHYL NITRATE Chemical Properties,Usage,Production

Originator

Transderm ,Scop Novartis Consumer Health Inc.

Uses

(-)Scopolamine Methylnitrate is a competitive antimuscarinic agent.

Manufacturing Process

In a one-liter separatory funnel, 94 g (0.215 mol) of scopolamine hydrobromide trihydrate was dissolved in 250 ml of water, made alkaline by shaking with 40 g (1 mol) of sodium hydroxide in 150 ml of water, and the free base immediately extracted with ether. As scopolamine is somewhat soluble in water, the aqueous layer was saturated with potassium carbonate and again extracted with ether. The combined ether extracts were dried over anhydrous magnesium sulfate and the ether removed by distillation, leaving 65 g (0.214 mol; 100% yield) of nearly colorless oil. Then 100 g (1.05 mol) of cold methyl bromide was added to a chilled, 500-ml pressure flask containing the 65 g of scopolamine, the flask stoppered tightly with a clamp, and allowed to stand at room temperature for 96 hours. The flask was cooled before opening, excess methyl bromide removed by distilling, and the white solid washed thoroughly with dry ether. The yield of crude Nmethylscopolammonium bromide was 80 g (94 %t yield). The salt was recrystallized from 550 ml of alcohol; first crop, 70 g, MP: 212-214°C; second crop, 6 g, melting point 195-200°C. The combined crops were again recrystallized from 500 ml of alcohol; melting point 210-212°C. The third recrystallization from 600 ml of alcohol yielded 64 g, melting point 214- 216°C, a 75 % yield based on scopolamine hydro-bromide trihydrate starting material. N-Methylscopolammonium bromide may be dissolved in water. An equivalent of solution AgNO3 was added, a precipitated AgBr was filtered off. The filtrate was evaporated to dryness to give the desired Nmethylscopolammonium nitrate.

brand name

Mesconit;Skopyle.

Therapeutic Function

Anticholinergic, Spasmolytic

World Health Organization (WHO)

Hyoscine methonitrate, a quaternary ammonium anticholinergic agent, was introduced in 1947 for use as a gastrointestinal antispasmodic. The action taken in Sweden relates to the use of this compound in preparations for suppressing the appetite. Preparations may remain available elsewhere.

SCOPOLAMINE METHYL NITRATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SCOPOLAMINE METHYL NITRATE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40240
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44700
Advantage
61
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9664
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Guangzhou Jhd Chemical Reagent Co., Ltd.
Tel
020-84383047
Fax
020-84380294
Email
sales@jhd.com.cn
Country
China
ProdList
9190
Advantage
65
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 13028896684
Email
sales@rrkchem.com
Country
China
ProdList
56056
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
info@afinechem.com
Country
China
ProdList
15396
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39916
Advantage
58
Antai Fine Chemical Technology Co.,Limited
Tel
18503026267
Email
info@antaichem.com
Country
CHINA
ProdList
9641
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
39997
Advantage
58
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-63373950 15353716720
Email
1052@dideu.com
Country
China
ProdList
10011
Advantage
58
Shanghai Maclean Biochemical Technology Co., LTD
Tel
021-50706066 15221275939
Email
shenlinxing@macklin.cn
Country
China
ProdList
29803
Advantage
58
LGC Science (Shanghai) Ltd.
Tel
17717235263
Email
cindy.yang@lgcgroup.com
Country
China
ProdList
11572
Advantage
58
Suzhou ARTK Medchem Co., Ltd.
Tel
+8618168183658
Email
sales1@artkmedchem.com
Country
China
ProdList
39009
Advantage
58
LEAPCHEM CO., LTD.
Tel
+86-852-30606658
Email
market18@leapchem.com
Country
China
ProdList
43348
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6942
Advantage
58
Shanghai Zhenyu Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2836767067@qq.com
Country
CHINA
ProdList
6970
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6921
Advantage
58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6979
Advantage
58
Beijing Yunbang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
yunbnagbio@163.com
Country
China
ProdList
6877
Advantage
50
Shanghai Jinshan Pharmaceutical Co., Ltd
Tel
--
Fax
--
Email
zouxiao8466@yahoo.com.cn
Country
China
ProdList
229
Advantage
56
Atomax Chemicals Co., Ltd
Tel
--
Fax
--
Email
info@atomaxchem.com
Country
China
ProdList
6498
Advantage
43
Guangzhou WeiBo Chemical Co., Ltd.
Tel
--
Fax
--
Email
weibochem@163.com
Country
China
ProdList
6187
Advantage
67

6106-46-3, SCOPOLAMINE METHYL NITRATERelated Search:


  • (-)SCOPOLAMINE METHYL NITRATE
  • SCOPOLAMINE METHYL NITRATE
  • METHSCOPOLAMINE NITRATE
  • HYOSCINE METHYL NITRATE
  • ,9-dimethyl-,[7(s)-(1alpha,2beta,4beta,5alpha,7beta)]-,nitrate(salt)
  • 1alphah,5alphah-tropanium,6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-,nitrate,
  • 4)non-7-ylester,(7(s)-(1alpha,2beta,4beta,5alpha,7beta))-.0comp
  • 5-alpha-h-tropanium,6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-1-alpha-n
  • 9-dimethyl--(7(s)-(1alpha,2beta,4beta,5alpha,7beta))--nitrate(salt)
  • alpha,-(hydroxymethyl)-benzeneaceticaci9-methyl-3-oxa-9-aztricyclo(3.3.1
  • dwithmethylnitrate1:1)
  • epoxytropinetropatemethylnitrate
  • itrate,(-)-tropate
  • mescomine
  • methylnitrate,compdwithscopolamine
  • methylscopolaminenitrate
  • n-methylscopolammoniumnitrate
  • scopolamine,compdwithmethylnitrate(1:1)
  • skopolate
  • skopyl
  • viscope
  • HYOSCINEMETHONITRATE
  • (-)-Scopolaminmethylnitrat
  • (-)-N-methylhyoscinium nitrate
  • Hyoscine methyl nitrate, Methscopolamine nitrate
  • METHYL HYOSCINE NITRATE
  • Scopolamine Methyl Nitrate &gt
  • (-)Scopolamine Methylnitrate
  • (-)-N-methylhyoscinium nitrate
  • Scopolamine (nitrate)
  • (-)-Scopolamine methyl nitrate
  • 6106-46-3
  • C17H21NO4CH3NO3
  • C18H24N2O7
  • C18H24NO4NO3
  • Tropane Alkaloids
  • Alkaloids
  • Alkaloids
  • Biochemistry
  • Tropane Alkaloids