D-Glutamic acid 1-tert-butyl ester

Product Name: D-Glutamic acid 1-tert-butyl ester
CAS No.: 25456-76-2
Chemical Name: D-Glutamic acid 1-tert-butyl ester
Synonyms: H-D-Glu-OtBu;(R)-4-amino-5-tert-butoxy-5-oxopentanoic acid;D-Glu-Otbu;H-D-GLU-OTBU HCL;REF DUPL: H-D-Glu-OtBu;D-GLUTAMIC ACID-OTBU HCL;D-Glutamine t-butyl ester;D-Glutamic acid 1-tert-butyl ester;D-Glutamicacid1-tert-butylester,98%;D-Glutamic acid alpha-tert-butyl ester
CBNumber: CB2460295
Molecular Formula: C9H17NO4
Formula Weight: 203.24
MOL File: 25456-76-2.mol

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D-Glutamic acid 1-tert-butyl ester Property

Melting point:: 144 - 146oC
Boiling point:: 326.8±32.0 °C(Predicted)
Density: 1.133
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Methanol (Slightly), Water (Slightly)
pka: 4.22±0.10(Predicted)
form: Powder
color: White
optical activity: Consistent with structure
Water Solubility: Slightly soluble in water.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: G597025
Product name: D-GlutamicAcid1-tert-ButylEster
Packaging: 1g
Price: $55
Updated: 2021/12/16

Activate Scientific

Product number: AS112874
Product name: H-D-Glu-OtBu
Purity: 97%
Packaging: 1g
Price: $59
Updated: 2021/12/16

Activate Scientific

Product number: AS112874
Product name: H-D-Glu-OtBu
Purity: 97%
Packaging: 5G
Price: $160
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 40671
Product name: D-Glutamicacid1-tert-butylester
Packaging: 1g
Price: $190
Updated: 2021/12/16

Activate Scientific

Product number: AS112874
Product name: H-D-Glu-OtBu
Purity: 97%
Packaging: 25g
Price: $551
Updated: 2021/12/16

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D-Glutamic acid 1-tert-butyl ester Chemical Properties,Usage,Production

Uses

D-Glutamic acid 1-tert-butyl ester, is an aminoacid which is widely used in pharmaceutical and food industry. It is also used as a pharmaceutical intermediate. It is also an important organic intermediate.

Definition

ChEBI: (R)-4-Amino-5-(tert-butoxy)-5-oxopentanoic acid is a glutamic acid derivative.

Synthesis

617-65-2

25456-75-1

Example 1: Synthesis of Di-tert-butyl Glutamate 10 g (68 mmol) of 2-aminoglutaric acid (glutamic acid) was suspended in 290 mL of tert-butyl acetate, 16.6 mL (0.15 mol) of 60% perchloric acid solution was added, and the solution was shaken for about 15 minutes until completely dissolved. The reaction solution was left to react at room temperature for 5 days. After completion of the reaction, the mixture was cooled to -5 °C (ice/NaCl bath) and extracted (4 times) with 0.5 N hydrochloric acid solution. The aqueous phase was neutralized to pH neutral with solid sodium carbonate and subsequently extracted with ether (6 times). All organic phases were combined, washed with saturated aqueous sodium bicarbonate solution (2 times), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give 3.5 g (20% yield) of di-tert-butyl glutamate, the product was a light yellow liquid.

References

[1] Patent: US5387707, 1995, A

D-Glutamic acid 1-tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Glutamic acid 1-tert-butyl ester Suppliers

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View Lastest Price from D-Glutamic acid 1-tert-butyl ester manufacturers

Career Henan Chemical Co

Product: D-Glutamic acid 1-tert-butyl ester 25456-76-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-22

25456-76-2, D-Glutamic acid 1-tert-butyl esterRelated Search:

Tris(trimethylsilyl)phosphate tert-Butyl bromoacetate tert-Butyl carbazate 2-Butoxyethanol tert-Butyl acrylate Buprofezin D(-)-Glutamic acid tert-Butanol tert-Butyl acetoacetate tert-Butyl acetate Methyl acrylate Diethyl phthalate Butyl acetate Butyl acrylate Glutamic acid t-butyl chloroformate H-D-GLU(OTBU)-OTBU HCL N-α-Fmoc-L-glutamic acid α-tert butyl ester,FMOC-L-GLUTAMIC ACID 1-TERT-BUTYL ESTER

(4R)-4-amino-5-(tert-butoxy)-5-oxopentanoic acid

D-Glutamic acid 1-tert-butyl ester

D-GLUTAMIC ACID ALPHA-T-BUTYL ESTER HYDROCHLORIDE

D-GLUTAMIC ACID-OTBU HCL

H-D-GLU-OTBU HCL

H-D-Glu-OtBu

D-Glutamine t-butyl ester

(R)-4-amino-5-tert-butoxy-5-oxopentanoic acid

REF DUPL: H-D-Glu-OtBu

D-Glutamic acid alpha-tert-butyl ester

D-Glutamic acid, 1-(1,1-dimethylethyl) ester

(4R)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoic acid

D-Glutamicacid1-tert-butylester,98%

(4R)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoicaci

D-Glutamic acid 1-tert-butyl ester USP/EP/BP

(4R)-4-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoi

D-Glu-Otbu

25456-76-2

Amino Acids and Derivatives

Amino Acid Derivatives