ChemicalBook > CAS DataBase List > endo BCN-O-PNB

endo BCN-O-PNB

Product Name
endo BCN-O-PNB
CAS No.
1263166-91-1
Chemical Name
endo BCN-O-PNB
Synonyms
endo-BCN-PNP-carbonate;endo BCN-PNP;BCN-PNP (ENDO);endo BCN-O-PNP;endo BCN-O-PNB;endo-BCN-PNB ester;endo BCN - active ester (p-NPC);endo BCN - active ester (p-NPE);[(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methyl (4-nitrophenyl) carbonate;((1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl 4-nitrophenyl carbonate
CBNumber
CB24665283
Molecular Formula
C17H17NO5
Formula Weight
315.33
MOL File
1263166-91-1.mol
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endo BCN-O-PNB Property

Boiling point:
475.7±37.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Storage temp. -20°C
solubility 
DMSO : 100 mg/mL (317.14 mM; Need ultrasonic)
form 
Solid
color 
White to off-white
InChI
InChI=1/C17H17NO5/c19-17(23-13-9-7-12(8-10-13)18(20)21)22-11-16-14-5-3-1-2-4-6-15(14)16/h7-10,14-16H,3-6,11H2/t14-,15+,16-
InChIKey
QXNXOXMDBLHIDB-MUJYYYPQNA-N
SMILES
C([C@H]1[C@@]2([H])CCC#CCC[C@@]12[H])OC(=O)OC1C=CC(N(=O)=O)=CC=1 |&1:1,2,10,r|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

BroadPharm
Product number
BP-20506
Product name
endo-BCN-PNP-carbonate
Purity
95%
Packaging
50mg
Price
$380
Updated
2021/12/16
BroadPharm
Product number
BP-20506
Product name
endo-BCN-PNP-carbonate
Purity
95%
Packaging
250mg
Price
$940
Updated
2021/12/16
BroadPharm
Product number
BP-20506
Product name
endo-BCN-PNP-carbonate
Purity
95%
Packaging
1g
Price
$1980
Updated
2021/12/16
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endo BCN-O-PNB Chemical Properties,Usage,Production

Description

endo-BCN-PNP-carbonate is a very reactive compound which can easily react with amine-containing molecules in organic solvents. PNP is a good leaving group. The BCN is used for copper-free Click Chemistry reactions.

Uses

endo-BCN-O-PNB is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-O-PNB is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

endo BCN-O-PNB Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from endo BCN-O-PNB manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
endo BCN-O-PNB 1263166-91-1
Price
US $0.00/mg
Min. Order
100mg
Purity
>98.00%
Supply Ability
1g
Release date
2024-03-20

1263166-91-1, endo BCN-O-PNBRelated Search:

BCN-OH endo-BCN-PEG4-acid - exo BCN-O-PNB endo-BCN-PEG4-NHS ester - (1R,8S,9r)-bicyclo[6.1.0]nonan-9-ylmethanol

  • endo BCN-O-PNB
  • [(1R,8S)-9-bicyclo[6.1.0]non-4-ynyl]methyl (4-nitrophenyl) carbonate
  • endo BCN-O-PNP
  • BCN-PNP (ENDO)
  • endo-BCN-PNB ester
  • endo BCN - active ester (p-NPE)
  • endo BCN - active ester (p-NPC)
  • endo-BCN-PNP-carbonate
  • rel-((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl (4-nitrophenyl) carbonate
  • ((1R,8S,9S)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl 4-nitrophenyl carbonate
  • Carbonic acid, (1α,8α,9β)-bicyclo[6.1.0]non-4-yn-9-ylmethyl 4-nitrophenyl ester
  • endo BCN-PNP
  • 1263166-91-1
  • SiChem