Morphothiadin
- Product Name
- Morphothiadin
- CAS No.
- 1092970-12-1
- Chemical Name
- Morphothiadin
- Synonyms
- GLS4 (GLS 4;Morphothiadin;Morphothiadin (GLS4);GLS 4(Morphothiadin);Morphothiadin USP/EP/BP;Morphothiadin, 10 mM in DMSO;Morphothiadin,inhibit,HBV,Inhibitor,GLS-4,GLS 4,Hepatitis B virus;Ethyl 4-(2-bromo-4-fluorophenyl)-6-(morpholinomethyl)-2-(thiazol-2-yl)-1,4-dihydropyrimidine-5-carboxylate;5-Pyrimidinecarboxylic acid, 4-(2-bromo-4-fluorophenyl)-1,4-dihydro-6-(4-morpholinylmethyl)-2-(2-thiazolyl)-, ethyl ester
- CBNumber
- CB24673505
- Molecular Formula
- C21H22BrFN4O3S
- Formula Weight
- 509.39
- MOL File
- 1092970-12-1.mol
Morphothiadin Property
- Boiling point:
- 577.2±60.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 12 mg/ml; DMSO: 1 mg/ml; Ethanol: Slightly soluble; PBS (pH 7.2): 0.3 mg/ml
- form
- A solid
- pka
- 8.38±0.10(Predicted)
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 35843
- Product name
- GLS4
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $83
- Updated
- 2026/04/30
- Product number
- 35843
- Product name
- GLS4
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $310
- Updated
- 2026/04/30
- Product number
- 35843
- Product name
- GLS4
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $455
- Updated
- 2026/04/30
- Product number
- 35843
- Product name
- GLS4
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $825
- Updated
- 2026/04/30
- Product number
- BA1817
- Product name
- Morphothiadin
- Packaging
- 1mg
- Price
- $108
- Updated
- 2026/05/06
Morphothiadin Chemical Properties,Usage,Production
Uses
Morphothiadin, is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM. It strongly inhibits virus accumulation in the supernatant of HepAD38 cells at 25 nM to 100 nM (P<0.02).
in vivo
The area under the concentration-time curve from 0 to 24 h (AUC0-24) of Morphothiadin (GLS4) is 556 h ng/mL. After intravenous administration of 10 mg/kg Morphothiadin, the total plasma clearance and apparent volume distribution are 4.2 liters/h/kg and 7.38 liters/kg, respectively. The bioavailability of Morphothiadin is 25.5%. It is found that virus titers have increased 83.5-fold in mice treated with 3.75 mg/kg per day of Morphothiadin, 28.3-fold among mice treated with 7.5 mg/kg per day, but only 3- to 6-fold among mice treated with the higher doses of Morphothiadin. There is generally an inverse relationship between Morphothiadin dose and virus titer, with the greatest rebound seen in mice treated with 3.75 mg/kg per day of Morphothiadin (540-fold) and the smallest rebound in mice treated with 60 mg/kg per day (23-fold) (P<0.001). The Morphothiadin doses of >7.5 mg/kg per day significantly suppresses the virus replication cycle throughout the treatment period, while Morphothiadin doses of >15 mg/kg per day suppresses virus for up to 2 weeks after the end of treatment[2].
Morphothiadin Preparation Products And Raw materials
Raw materials
Preparation Products
Morphothiadin Suppliers
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- 400-400-164-7117 18317119277
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- +86-21-61629029
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- Country
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View Lastest Price from Morphothiadin manufacturers
- Product
- Morphothiadin 1092970-12-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-21
- Product
- Morphothiadin 1092970-12-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 600 Tons
- Release date
- 2020-05-03