ChemicalBook > CAS DataBase List > 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid

2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid

Product Name: 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
CAS No.: 4442-53-9
Chemical Name: 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
Synonyms: 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid;2,3-DIHYDRO-BENZO[1,4]DIOXINE-5-CARBOXYLIC ACID;4-(2;3-Dihydro-1;AKOS BBS-00002750;2,3-Dihydro-1,4-benz;5-CARBOXY-1,4-BENZODIOXANE;Compound 3344 hydrochloride;2,3-Ethylenedioxybenzoic Acid;4-benzodioxine-5-carboxylic acid
CBNumber: CB2467643
Molecular Formula: C9H8O4
Formula Weight: 180.16
MOL File: 4442-53-9.mol

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2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Property

Melting point:: 90-94 °C(lit.)
Boiling point:: 334.1±41.0 °C(Predicted)
Density: 1.376±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 4.09±0.20(Predicted)
color: Light yellow to Brown
InChIKey: VCLSWKVAHAJSFL-UHFFFAOYSA-N
CAS DataBase Reference: 4442-53-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39-36/37/38
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29329900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 563331
Product name: 1,4-Benzodioxan-5-carboxylic acid
Purity: 98%
Packaging: 5g
Price: $69.2
Updated: 2023/06/20

TCI Chemical

Product number: B3864
Product name: 1,4-Benzodioxane-5-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: B3864
Product name: 1,4-Benzodioxane-5-carboxylic Acid
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $194
Updated: 2025/07/31

TRC

Product number: B203528
Product name: 1,4-Benzodioxan-5-carboxylic acid
Packaging: 1g
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139597
Product name: 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid
Packaging: 10g
Price: $100
Updated: 2021/12/16

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2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Synthesis

29668-43-7

4442-53-9

The general procedure for the synthesis of 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid from 2,3-dihydrobenzo[b][1,4]dioxane-5-carboxaldehyde was as follows: 2,3-dihydrobenzo[b][1,4]dioxane-5-carboxaldehyde (0.500 g, 3.04 mmol) was dissolved in acetone (10 mL) and mixed with an aqueous solution of sulfamic acid at 0-5 °C ( 0.455 g, 4.5 mmol) was mixed and stirred. After the reaction mixture was stirred for 20 minutes, aqueous sodium chlorite (0.421 g, 4.5 mmol) was added and the reaction was continued for 18 hours at room temperature. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and quenched with water. The resulting solid was collected by filtration and dried under vacuum to afford the target product 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid (0.332 g). The product was characterized as follows: 1H NMR (DMSO-d6): δ 4.27 (s, 4H), 6.84 (t, J = 7.2 Hz, 1H), 7.02 (d, J = 7.8 Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 12.5 (bs, 1H); MS [M + H]+: 181.12.

References

[1] Patent: WO2013/153535, 2013, A1. Location in patent: Page/Page column 63

2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid 4442-53-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: as request
Release date: 2018-12-24

4442-53-9, 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acidRelated Search:

PHTHALIC ACID DISODIUM SALT CALCIUM DODECYLBENZENE SULFONATE Potassium hydrogen phthalate Dodecylbenzenesulphonic acid DODECYLBENZENE Benzo[b]thien-2-ylboronic acid 2,3-DIHYDRO-1,4-BENZODIOXINE-2-CARBOXYLIC ACID 2,3-dihydro-1,4-benzodioxine -5-carboxylic acid methyl ester 2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOXYLIC ACID 2,3-dihydro-1,4-benzodioxine -6-carboxylic acid methyl ester 1,4-Benzodioxan 6,7-Dibromo-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid 6,7-Dibromo-8-nitro-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid 8-Amino-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid ethyl ester 8-Amino-7-chloro-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid ethyl ester 8-Amino-2,3-dihydrobenzo[1,4]dioxine-5-carboxylic acid 7-AMINO-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOXYLIC ACID 7-BROMO-2,3-DIHYDRO-1,4-BENZODIOXINE-6-CARBOXYLIC ACID

2,3,4a,8a-tetrahydro-1,4-benzodioxin-5-carboxylic acid

AKOS BBS-00002750

7,10-dioxabicyclo[4.4.0]deca-1,3,5-triene-2-carboxylic acid

5-CARBOXY-1,4-BENZODIOXANE

1,4-BENZODIOXAN-5-CARBOXYLIC ACID

1,4-BENZODIOXANE-5-CARBOXYLIC ACID

2,3-DIHYDRO-BENZO[1,4]DIOXINE-5-CARBOXYLIC ACID

2,3-DIHYDRO-1,4-BENZODIOXINE-5-CARBOXYLIC ACID

2,3-dihydro-1,4-benzodioxin-5-carboxylic acid

1,4-Benzodioxine-5-carboxylicacid

2,3-DIHYDRO-1,4-BENZODIOXAN-5-CARBOXYLIC ACID,99%

2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid

2,3-Dihydro-1,4-benzodioxane-5-hydroxyacid

1,4-Benzodioxin-5-carboxylic acid, 2,3-dihydro-

2,3-Dihydro-1,4-benz

3-Dihydro-1

4-benzodioxine-5-carboxylic acid

1,4-Benzodioxan-5-carboxylic acid/2,3-Dihydro-1,4-Benzodioxine-5-Carboxylic Acid

1,4-Benzodioxan-5-carboxylic acid,98%

2,3-Ethylenedioxybenzoic Acid

2,3-dihydro-1,4-benzodioxane-5-carboxylic acid

5-Carboxy-2,3-dihydro-1,4-benzodioxine, 1,4-Benzodioxane-5-carboxylic acid

1,4-Benzodioxane-5-carboxylicAcid&gt

4-(2

4-benzodioxin-5-yl)-~{N}-[3-[(dimethylamino)methyl]phenyl]-2-methoxy-aniline hydrochloride(2368246-78-8 free base)

Compound 3344 hydrochloride

Compound 3344 hydrochloride (2368246-78-8 free base)

4442-53-9

Building Blocks

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Benzodiozoles, Benzodioxines & Benzodioxepines

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