2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
- Product Name
- 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
- CAS No.
- 4442-53-9
- Chemical Name
- 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid
- Synonyms
- 2,3-dihydrobenzo[b][1,4]dioxine-5-carboxylic acid;2,3-DIHYDRO-BENZO[1,4]DIOXINE-5-CARBOXYLIC ACID;4-(2;3-Dihydro-1;AKOS BBS-00002750;2,3-Dihydro-1,4-benz;5-CARBOXY-1,4-BENZODIOXANE;Compound 3344 hydrochloride;2,3-Ethylenedioxybenzoic Acid;4-benzodioxine-5-carboxylic acid
- CBNumber
- CB2467643
- Molecular Formula
- C9H8O4
- Formula Weight
- 180.16
- MOL File
- 4442-53-9.mol
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Property
- Melting point:
- 90-94 °C(lit.)
- Boiling point:
- 334.1±41.0 °C(Predicted)
- Density
- 1.376±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 4.09±0.20(Predicted)
- color
- Light yellow to Brown
- InChIKey
- VCLSWKVAHAJSFL-UHFFFAOYSA-N
- CAS DataBase Reference
- 4442-53-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39-36/37/38
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29329900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 563331
- Product name
- 1,4-Benzodioxan-5-carboxylic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $69.2
- Updated
- 2023/06/20
- Product number
- B3864
- Product name
- 1,4-Benzodioxane-5-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $49
- Updated
- 2025/07/31
- Product number
- B3864
- Product name
- 1,4-Benzodioxane-5-carboxylic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $194
- Updated
- 2025/07/31
- Product number
- B203528
- Product name
- 1,4-Benzodioxan-5-carboxylic acid
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J51803
- Product name
- 1,4-Benzodioxan-5-carboxylic acid
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powder
Synthesis
29668-43-7
4442-53-9
The general procedure for the synthesis of 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid from 2,3-dihydrobenzo[b][1,4]dioxane-5-carboxaldehyde was as follows: 2,3-dihydrobenzo[b][1,4]dioxane-5-carboxaldehyde (0.500 g, 3.04 mmol) was dissolved in acetone (10 mL) and mixed with an aqueous solution of sulfamic acid at 0-5 °C ( 0.455 g, 4.5 mmol) was mixed and stirred. After the reaction mixture was stirred for 20 minutes, aqueous sodium chlorite (0.421 g, 4.5 mmol) was added and the reaction was continued for 18 hours at room temperature. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and quenched with water. The resulting solid was collected by filtration and dried under vacuum to afford the target product 2,3-dihydro-1,4-benzodioxane-5-carboxylic acid (0.332 g). The product was characterized as follows: 1H NMR (DMSO-d6): δ 4.27 (s, 4H), 6.84 (t, J = 7.2 Hz, 1H), 7.02 (d, J = 7.8 Hz, 1H), 7.20 (d, J = 7.5 Hz, 1H), 12.5 (bs, 1H); MS [M + H]+: 181.12.
References
[1] Patent: WO2013/153535, 2013, A1. Location in patent: Page/Page column 63
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid manufacturers
- Product
- 2,3-Dihydro-1,4-benzodioxine-5-carboxylic acid 4442-53-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24