5-Amino-2-chlorobenzonitrile
- Product Name
- 5-Amino-2-chlorobenzonitrile
- CAS No.
- 35747-58-1
- Chemical Name
- 5-Amino-2-chlorobenzonitrile
- Synonyms
- 4-Chloro-3-cyanoaniline;3-CYANO-4-CHLOROANILINE HCL;5-AMINO-2-CHLOROBENZONITRILE;5-aMino-5-chlorobenzonitrile;2-CHLORO-5-AMINO BENZONITRILE;Benzonitrile, 5-amino-2-chloro-
- CBNumber
- CB2471422
- Molecular Formula
- C7H5ClN2
- Formula Weight
- 152.58
- MOL File
- 35747-58-1.mol
5-Amino-2-chlorobenzonitrile Property
- Melting point:
- 115.5°C
- Boiling point:
- 250.67°C (rough estimate)
- Density
- 1.9802 (rough estimate)
- refractive index
- 1.6100 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 2.15±0.10(Predicted)
- Appearance
- Light yellow to brown Solid
- CAS DataBase Reference
- 35747-58-1(CAS DataBase Reference)
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A617703
- Product name
- 5-Amino-2-chlorobenzonitrile
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J51655
- Product name
- 3-Cyano-4-chloroanilineHCl
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA67240
- Product name
- 5-Amino-2-chlorobenzonitrile
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D146
- Product name
- 3-Cyano-4-chloroanilineHCl
- Packaging
- 5g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- J51655
- Product name
- 3-Cyano-4-chloroanilineHCl
- Packaging
- 10g
- Price
- $80
- Updated
- 2021/12/16
5-Amino-2-chlorobenzonitrile Chemical Properties,Usage,Production
Uses
5-Amino-2-chlorobenzonitrile is a useful research reagent for organic synthesis and other chemical transformations.
Synthesis
16588-02-6
35747-58-1
The general procedure for the synthesis of 3-cyano-4-chloroaniline from 2-chloro-5-nitrobenzonitrile was as follows: 2-chloro-5-nitrobenzonitrile (10 g, 54.8 mmol) was heated and refluxed for 1 h in a mixture of isopropanol (125 mL) and concentrated hydrochloric acid (62.5 mL) with stannous chloride dihydrate (56 g, 248.6 mmol). Upon completion of the reaction, the mixture was cooled to room temperature and neutralized with 2N sodium hydroxide solution. Subsequently, the aqueous layer was extracted with dichloromethane, the organic layers were combined and dried with anhydrous magnesium sulfate. The organic layer was concentrated under reduced pressure to afford 3-cyano-4-chloroaniline (8 g, 96% yield). The product was analyzed by high performance liquid chromatography (HPLC) under the following purity detection conditions: detection wavelength 210-370 nm; retention time (RT) 7.2 min; mobile phase 10 mM ammonium formate buffer (pH 3.5)/acetonitrile + methanol (gradient elution from 85/15 to 5/95) for 10 min, hold for 4 min; chromatography column Xterra TM RP18 (3.5 μm, 150×4.6 mm); mobile phase 1.5 μm, 2.5 μm, 2.5 μm, 2.5 μm, 2.5 μm, 2.5 μm. m, 150×4.6 mm); the flow rate was 1.2 mL/min.
References
[1] Tetrahedron Letters, 1984, vol. 25, # 8, p. 839 - 842
[2] Patent: US2007/27126, 2007, A1. Location in patent: Page/Page column 16
[3] Patent: US2007/27201, 2007, A1. Location in patent: Page/Page column 23
[4] Patent: US9204645, 2015, B2. Location in patent: Page/Page column 54; 55
[5] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 3, p. 685 - 695
5-Amino-2-chlorobenzonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Amino-2-chlorobenzonitrile manufacturers
- Product
- 5-Amino-2-chlorobenzonitrile 35747-58-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kgs
- Release date
- 2019-12-25