1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- Product Name
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- CAS No.
- 108468-00-4
- Chemical Name
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- Synonyms
- 4-(Boc-aMinoMethyl)benzylaMine;N-Boc-4-(aminomethyl)benzylamine;1-(N-BOC-AMINOMETHYL)-4-(AMINOMETHYL) BE;tert-Butyl 4-(Aminomethyl)benzylcarbamate;1-(N-BOC-AMINOMETHYL)-3-(AMINOMETHYL)BENZENE;1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene;tert-Butyl N-[4-(aminomethyl)benzyl]carbamate;4-(tert-Butoxycarbonylaminomethyl)benzylamine;1-(N-Boc-aMinoMethyl)-4-(aMinoMethyl)benzene 95%;1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- CBNumber
- CB2474670
- Molecular Formula
- C13H20N2O2
- Formula Weight
- 236.31
- MOL File
- 108468-00-4.mol
1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene Property
- Melting point:
- 64-68 °C (lit.)
- Boiling point:
- 250 °C(lit.)
- Density
- 1.06 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.523(lit.)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- Powder
- pka
- 12.29±0.46(Predicted)
- color
- White to slightly yellow-pink or beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 539449
- Product name
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- Purity
- 95%
- Packaging
- 1g
- Price
- $79.89
- Updated
- 2025/07/31
- Product number
- 539449
- Product name
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- Purity
- 95%
- Packaging
- 5g
- Price
- $247.8
- Updated
- 2025/07/31
- Product number
- B699953
- Product name
- 1-(N-Boc-Aminomethyl)-4-(aminomethyl)benzene
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB139340
- Product name
- tert-Butyl 4-(aminomethyl)benzylcarbamate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- X8881
- Product name
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene Chemical Properties,Usage,Production
Uses
1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene may be used for the synthesis of:
- oligomeric thioureas
- bipyrrole-based[2]catenane
- model receptors for dicarboxylates and monosaccharides
General Description
1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene is a protected amine.
Synthesis
24424-99-5
539-48-0
108468-00-4
The general procedure for the synthesis of 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene from di-tert-butyl dicarbonate and 1,4-benzenedimethanamine was as follows: a solution of di-tert-butyl dicarbonate (19.0 g, 87 mmol) in dichloromethane (50 mL) was slowly added dropwise to a cooled-to-0°C suspension of 1,4-benzenedimethanamine (44.0 g, 323 mmol) in dichloromethane ( 200 mL) suspension, and the dropwise addition time was controlled to be more than 30 minutes. Subsequently, the reaction mixture was gradually warmed up to room temperature over 2 hours. Upon completion of the reaction, the reaction mixture was washed with 1N aqueous sodium hydroxide (300 mL), the organic phase was separated, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a colorless solid product. Finally, the product was purified by fast column chromatography with the eluent of dichloromethane:methanol:880 ammonia (94:6:1, v/v, in that order) to afford the target compound 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene as a colorless solid (9.61 g, 47% yield).
References
[1] Journal of Materials Chemistry, 2008, vol. 18, # 41, p. 4917 - 4927
[2] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 19, p. 4189 - 4206
[3] Journal of Organic Chemistry, 1996, vol. 61, # 25, p. 8811 - 8818
[4] Journal of the American Chemical Society, 2008, vol. 130, # 18, p. 6025 - 6039
[5] Patent: WO2004/108675, 2004, A1. Location in patent: Page 115
1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene Suppliers
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View Lastest Price from 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene manufacturers
- Product
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene 108468-00-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene 108468-00-4
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-(N-Boc-aminomethyl)-4-(aminomethyl)benzene 108468-00-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 25kg
- Release date
- 2019-07-11