4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE
- Product Name
- 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE
- CAS No.
- 103962-10-3
- Chemical Name
- 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE
- Synonyms
- BUTTPARK 35\01-56;4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE;p-(Trifluoromethoxy)phenacyl Bromide;5-(Trifluoromethoxy)phenacyl bromide;1,1,1-Trifluoromethoxypent-3-en-2-one;4-(Trifluoromethoxy)phenacylbromide97%;2-brom-4'-(trifluormethoxy)-acetophenon;4-(Trifluoromethoxy)phenacyl bromide 97%;2-Bromo-4'-(trifluoromethoxy)acetophenone;2-broMo-1-(4-(trifluoroMethoxy)phenyl)ethanone
- CBNumber
- CB2478416
- Molecular Formula
- C9H6BrF3O2
- Formula Weight
- 283.04
- MOL File
- 103962-10-3.mol
4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE Property
- Melting point:
- 55 °C
- Boiling point:
- 266.0±35.0 °C(Predicted)
- Density
- 1.621±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- Solid
- color
- Pale yellow
- CAS DataBase Reference
- 103962-10-3(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi
- Risk Statements
- 34-36/37/38-36
- Safety Statements
- 26-36/37/39
- RIDADR
- 1759
- WGK Germany
- 3
- HazardClass
- CORROSIVE
- HS Code
- 2914500090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 669474
- Product name
- 2-Bromo-4′-(trifluoromethoxy)acetophenone
- Purity
- 97%
- Packaging
- 1g
- Price
- $79.7
- Updated
- 2025/07/31
- Product number
- 669474
- Product name
- 2-Bromo-4′-(trifluoromethoxy)acetophenone
- Purity
- 97%
- Packaging
- 5g
- Price
- $110.6
- Updated
- 2025/07/31
- Product number
- B200055
- Product name
- 2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one
- Packaging
- 25g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 2617-B-54
- Product name
- 4-(Trifluoromethoxy)phenacyl bromide
- Purity
- 97%
- Packaging
- 5G
- Price
- $55
- Updated
- 2021/12/16
- Product number
- PC7439KM
- Product name
- 4-(Trifluoromethoxy)phenacylbromide
- Purity
- 97%
- Packaging
- 100g
- Price
- $210
- Updated
- 2021/12/16
4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE Chemical Properties,Usage,Production
Uses
2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one is an intermediate used to prepare aminothiazoles as therapeutic leads for prion diseases. It is also used in the synthesis of pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
Synthesis
85013-98-5
103962-10-3
General procedure for the synthesis of 2-bromo-1-[4-(trifluoromethoxy)phenyl]ethanone from 4'-(trifluoromethoxy)acetophenone: To a preheated (80 °C) stirred solution of copper(II) bromide (17.2 g, 77.2 mmol) in ethyl acetate (20 mL) was slowly added 4'-(trifluoromethoxy)acetophenone (8.7 g, 42.89 mmol) in a chloroform (10 mL) solution. The reaction mixture was stirred continuously at 80 °C for 4 h, during which the progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was subsequently concentrated under reduced pressure to give the crude product. The crude product was further purified by silica gel column chromatography with an eluent of 2-2.5% dichloromethane/hexane mixed solvent, resulting in the target compound 2-bromo-1-[4-(trifluoromethoxy)phenyl]ethanone (7 g, 58.0% yield) as an off-white solid. Its 1H NMR (400 MHz, CDCl3) data were as follows: δ 8.05 (d, J=8.0 Hz, 2H), 7.32 (d, J=8.8 Hz, 2H), 4.41 (s, 2H).
References
[1] Journal of Medicinal Chemistry, 2017, vol. 60, # 18, p. 7677 - 7702
[2] Patent: WO2018/165520, 2018, A1. Location in patent: Page/Page column 223
[3] Patent: WO2013/131408, 2013, A1. Location in patent: Page/Page column 128
[4] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 253 - 266
[5] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 4, p. 1432 - 1435
4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE manufacturers
- Product
- 4-(TRIFLUOROMETHOXY)PHENACYL BROMIDE 103962-10-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2020-01-09