5-Chloro-2-hydroxy-3-nitropyridine

Product Name: 5-Chloro-2-hydroxy-3-nitropyridine
CAS No.: 21427-61-2
Chemical Name: 5-Chloro-2-hydroxy-3-nitropyridine
Synonyms: 5-Chlo;NSC 64258;5-Chloro-3-nitro-2-pyridone;5-CHLORO-3-NITRO-2-PYRIDINOL;5-CHLORO-3-NITROPYRIDIN-2-OL;oro-2-hydroxy-3-nitropyridine;5-chloro-3-nitro-1H-pyridin-2-one;5-Chloro-3-nitro-2(1H)-pyridinone;5-chloro-3-nitropyridin-2(1H)-one;5-Chloro-3-nitropyridin-2-ol, 95+%
CBNumber: CB2479170
Molecular Formula: C5H3ClN2O3
Formula Weight: 174.54
MOL File: 21427-61-2.mol

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5-Chloro-2-hydroxy-3-nitropyridine Property

Melting point:: 232-236 °C
Boiling point:: 284.1±40.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Dimethylformamide
form: powder to crystal
pka: 6.31±0.10(Predicted)
color: Light yellow to Yellow to Green
BRN: 383852
CAS DataBase Reference: 21427-61-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-39-36-37
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 679747
Product name: 5-Chloro-2-hydroxy-3-nitropyridine
Purity: 97%
Packaging: 1g
Price: $124
Updated: 2023/01/07

TCI Chemical

Product number: C1972
Product name: 5-Chloro-2-hydroxy-3-nitropyridine
Purity: >98.0%(T)
Packaging: 5g
Price: $136
Updated: 2025/07/31

TCI Chemical

Product number: C1972
Product name: 5-Chloro-2-hydroxy-3-nitropyridine
Purity: >98.0%(T)
Packaging: 25g
Price: $404
Updated: 2025/07/31

TRC

Product number: C366650
Product name: 5-Chloro-2-hydroxy-3-nitropyridine
Packaging: 5g
Price: $90
Updated: 2021/12/16

TRC

Product number: C366650
Product name: 5-Chloro-2-hydroxy-3-nitropyridine
Packaging: 10g
Price: $140
Updated: 2021/12/16

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5-Chloro-2-hydroxy-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

White to light brown solid

Uses

5-Chloro-2-hydroxy-3-nitropyridine (cas# 21427-61-2) is a compound useful in organic synthesis.

Synthesis

1072-98-6

21427-61-2

Preparation of Example A2 5-chloro-2-hydroxy-3-nitropyridine (STR9): 321 g of 2-amino-5-chloropyridine was slowly added dropwise to 1.25 L of concentrated sulfuric acid with continuous stirring until the raw material was completely dissolved. Subsequently, 172.5 g of sodium nitrite (dissolved in 240 mL of water) was slowly added at 40°C to 45°C and the reaction mixture continued to be stirred for 15 minutes. Next, 125 mL of pure nitric acid was slowly added dropwise over 40 minutes at 50°C. The reaction mixture was maintained at 55°C for 1 hour and then the reaction was quenched by pouring into 5 kg of ice water. The yellow precipitated product was collected by filtration, washed thoroughly with deionized water and dried at 60°C to afford 351 g of 5-chloro-2-hydroxy-3-nitropyridine in 80.5% of the theoretical yield and a melting point of 229°C to 231°C.

References

[1] Patent: US5274100, 1993, A
[2] Yakugaku Zasshi, 1952, vol. 72, p. 431
[3] Chem.Abstr., 1953, p. 6404

5-Chloro-2-hydroxy-3-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-chloropyridine Nitric acid

Preparation Products

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View Lastest Price from 5-Chloro-2-hydroxy-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-Chloro-2-hydroxy-3-nitropyridine 21427-61-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Hebei Chuanghai Biotechnology Co., Ltd

Product: 5-Chloro-2-hydroxy-3-nitropyridine 21427-61-2
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-13

Henan Fengda Chemical Co., Ltd

Product: 5-Chloro-2-hydroxy-3-nitropyridine 21427-61-2
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

21427-61-2, 5-Chloro-2-hydroxy-3-nitropyridineRelated Search:

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5-CHLORO-3-NITRO-2-PYRIDINOL

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5-Chloro-2-hydroxy-3-nitropyridine ,97%

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5-Chloro-3-nitro-2(1H)-pyridinone

NSC 64258

5-chloro-3-nitro-1H-pyridin-2-one

5-Chlo

5-Chloro-2-hydroxy-3-nitropyridine &gt

oro-2-hydroxy-3-nitropyridine

2(1H)-Pyridinone, 5-chloro-3-nitro-

5-Chloro-3-nitro-2-pyridone

5-Chloro-2-hydroxy-3-nitropyridine ISO 9001：2015 REACH

5-CHLORO-3-NITRO-2-PYRIDONE (2-HYDROXY-3-NITRO-5-CHLOROPYRIDINE)

5-CHLORO-3-NITRO-2-PYRIDINE (2-HYDROXY-3-NITRO-5-CHLOROPYRIDINE)

5-chloro-3-nitropyridin-2(1H)-one

21427-61-2

C5H3N2O3Cl

C5H3ClN2O3

Halopyridines

Chloropyridines

Heterocycle-Pyridine series

Chloropyridines

Halopyridines

Bases & Related Reagents

Nucleotides

blocks

NitroCompounds

Pyridines

Pyridine