6-Methyl-2-pyridinecarboxylic acid
- Product Name
- 6-Methyl-2-pyridinecarboxylic acid
- CAS No.
- 934-60-1
- Chemical Name
- 6-Methyl-2-pyridinecarboxylic acid
- Synonyms
- 6-METHYLPICOLINIC ACID;6-METHYLPYRIDINE-2-CARBOXYLIC ACID;NSC 26023;NSC 109143;IFLAB-BB F1790-0068;RARECHEM AL BO 1402;-2-pyridinecarboxyL;Picolinic acid, 6-methyl-;6-METHYL-2-PICOLINIC ACID;6-Methylpicolinic acid,97%
- CBNumber
- CB2483171
- Molecular Formula
- C7H7NO2
- Formula Weight
- 137.14
- MOL File
- 934-60-1.mol
6-Methyl-2-pyridinecarboxylic acid Property
- Melting point:
- 130 °C
- Boiling point:
- 100°C/4.5mm
- Density
- 1.230±0.06 g/cm3(Predicted)
- Flash point:
- 100°C/4.5mm
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- pka
- pK1:5.83 (25°C)
- color
- White to Almost white
- InChI
- InChI=1S/C7H7NO2/c1-5-3-2-4-6(8-5)7(9)10/h2-4H,1H3,(H,9,10)
- InChIKey
- LTUUGSGSUZRPRV-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC(C)=CC=C1
- CAS DataBase Reference
- 934-60-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 6-Methyl picolinic acid(934-60-1)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M0873
- Product name
- 6-Methylpyridine-2-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $46
- Updated
- 2025/07/31
- Product number
- M0873
- Product name
- 6-Methylpyridine-2-carboxylic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- M337943
- Product name
- 6-Methyl-2-pyridinecarboxylicAcid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- A826
- Product name
- 6-Methyl-2-pyridinecarboxylicacid
- Packaging
- 25g
- Price
- $93
- Updated
- 2021/12/16
- Product number
- 058455
- Product name
- 6-Methyl-2-pyridinecarboxylic acid
- Purity
- 95+%
- Packaging
- 25g
- Price
- $109
- Updated
- 2021/12/16
6-Methyl-2-pyridinecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
White to beige powder
Uses
Pharmacological activity studied in regard to:
- Interactions of carrier ligands of antidiabetic metal complexes with human serum albumin
- Ability to chelate metalloenzyme inhibitors
- Interactions of insulin-mimetic zinc(II) complexes with cell constituents
Reactant for:
- Synthesis of inhibitors of human 11β -hydroxysteroid dehydrogenase type 1
- Lewis base organocatalysts for stereoselective hydrosilylation reactions
Biological studies of insulin-enhancing complexes
General Description
6-Methylpyridine-2-carboxylic acid (2-carboxy-6-methylpyridine, 6-methylpicolinic acid) is a heterocyclic building block.
Synthesis
108-48-5
934-60-1
Step 1: 2,6-dimethylpyridine (10.71 g, 0.1 mol) was dissolved in 500 mL of deionized water, stirred and heated to 60 °C. Subsequently, potassium permanganate (KMnO4, 23.7 g, 0.15 mol) was added in ten portions, with an interval of 30 min between each addition. The temperature was strictly controlled at about 60°C during the reaction, which lasted for 5 h and then stopped. Immediately after completion of the reaction, the insoluble impurities were removed by filtration. The filtrate was adjusted to pH=5 and then extracted with ethyl acetate. The organic phase was collected, concentrated under reduced pressure and finally recrystallized from ethanol to obtain 6-methyl-2-pyridinecarboxylic acid (10.3 g, 75% yield). In this step, the effects of different reaction conditions (e.g., equivalents of KMnO4 of 1, 1.5 and 2, aqueous potassium permanganate solution of different pH, temperature and molar ratio) on the reaction were investigated by orthogonal tests, and the optimal reaction conditions were determined to be neutral aqueous potassium permanganate solution with a dosage of 1.5 equivalents of KMnO4.
References
[1] Patent: CN105294552, 2016, A. Location in patent: Paragraph 0047; 0048; 0049; 0050
[2] Chemische Berichte, 1900, vol. 33, p. 1226
[3] Chemische Berichte, 1900, vol. 33, p. 1081
[4] Chemische Berichte, 1900, vol. 33, p. 1230
[5] Journal of Organic Chemistry, 1949, vol. 14, p. 14,17
6-Methyl-2-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methyl-2-pyridinecarboxylic acid manufacturers
- Product
- 6-Methyl-2-pyridinecarboxylic acid 934-60-1
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-09
- Product
- 6-Methyl-2-pyridinecarboxylic acid 934-60-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 6-Methyl-2-pyridinecarboxylic acid 934-60-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24