ChemicalBook > CAS DataBase List > 6-Methyl-2-pyridinecarboxylic acid

6-Methyl-2-pyridinecarboxylic acid

Product Name
6-Methyl-2-pyridinecarboxylic acid
CAS No.
934-60-1
Chemical Name
6-Methyl-2-pyridinecarboxylic acid
Synonyms
6-METHYLPICOLINIC ACID;6-METHYLPYRIDINE-2-CARBOXYLIC ACID;NSC 26023;NSC 109143;IFLAB-BB F1790-0068;RARECHEM AL BO 1402;-2-pyridinecarboxyL;Picolinic acid, 6-methyl-;6-METHYL-2-PICOLINIC ACID;6-Methylpicolinic acid,97%
CBNumber
CB2483171
Molecular Formula
C7H7NO2
Formula Weight
137.14
MOL File
934-60-1.mol
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6-Methyl-2-pyridinecarboxylic acid Property

Melting point:
130 °C
Boiling point:
100°C/4.5mm
Density 
1.230±0.06 g/cm3(Predicted)
Flash point:
100°C/4.5mm
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Soluble in water
form 
powder to crystal
pka
pK1:5.83 (25°C)
color 
White to Almost white
InChI
InChI=1S/C7H7NO2/c1-5-3-2-4-6(8-5)7(9)10/h2-4H,1H3,(H,9,10)
InChIKey
LTUUGSGSUZRPRV-UHFFFAOYSA-N
SMILES
C1(C(O)=O)=NC(C)=CC=C1
CAS DataBase Reference
934-60-1(CAS DataBase Reference)
NIST Chemistry Reference
6-Methyl picolinic acid(934-60-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M0873
Product name
6-Methylpyridine-2-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$46
Updated
2025/07/31
TCI Chemical
Product number
M0873
Product name
6-Methylpyridine-2-carboxylic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$152
Updated
2025/07/31
TRC
Product number
M337943
Product name
6-Methyl-2-pyridinecarboxylicAcid
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
A826
Product name
6-Methyl-2-pyridinecarboxylicacid
Packaging
25g
Price
$93
Updated
2021/12/16
Matrix Scientific
Product number
058455
Product name
6-Methyl-2-pyridinecarboxylic acid
Purity
95+%
Packaging
25g
Price
$109
Updated
2021/12/16
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6-Methyl-2-pyridinecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

White to beige powder

Uses

Pharmacological activity studied in regard to:

  • Interactions of carrier ligands of antidiabetic metal complexes with human serum albumin
  • Ability to chelate metalloenzyme inhibitors
  • Interactions of insulin-mimetic zinc(II) complexes with cell constituents

Reactant for:
  • Synthesis of inhibitors of human 11β -hydroxysteroid dehydrogenase type 1
  • Lewis base organocatalysts for stereoselective hydrosilylation reactions

Biological studies of insulin-enhancing complexes

General Description

6-Methylpyridine-2-carboxylic acid (2-carboxy-6-methylpyridine, 6-methylpicolinic acid) is a heterocyclic building block.

Synthesis

108-48-5

934-60-1

Step 1: 2,6-dimethylpyridine (10.71 g, 0.1 mol) was dissolved in 500 mL of deionized water, stirred and heated to 60 °C. Subsequently, potassium permanganate (KMnO4, 23.7 g, 0.15 mol) was added in ten portions, with an interval of 30 min between each addition. The temperature was strictly controlled at about 60°C during the reaction, which lasted for 5 h and then stopped. Immediately after completion of the reaction, the insoluble impurities were removed by filtration. The filtrate was adjusted to pH=5 and then extracted with ethyl acetate. The organic phase was collected, concentrated under reduced pressure and finally recrystallized from ethanol to obtain 6-methyl-2-pyridinecarboxylic acid (10.3 g, 75% yield). In this step, the effects of different reaction conditions (e.g., equivalents of KMnO4 of 1, 1.5 and 2, aqueous potassium permanganate solution of different pH, temperature and molar ratio) on the reaction were investigated by orthogonal tests, and the optimal reaction conditions were determined to be neutral aqueous potassium permanganate solution with a dosage of 1.5 equivalents of KMnO4.

References

[1] Patent: CN105294552, 2016, A. Location in patent: Paragraph 0047; 0048; 0049; 0050
[2] Chemische Berichte, 1900, vol. 33, p. 1226
[3] Chemische Berichte, 1900, vol. 33, p. 1081
[4] Chemische Berichte, 1900, vol. 33, p. 1230
[5] Journal of Organic Chemistry, 1949, vol. 14, p. 14,17

6-Methyl-2-pyridinecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-Methyl-2-pyridinecarboxylic acid manufacturers

Henan Fengda Chemical Co., Ltd
Product
6-Methyl-2-pyridinecarboxylic acid 934-60-1
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-09
Dideu Industries Group Limited
Product
6-Methyl-2-pyridinecarboxylic acid 934-60-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-25
Career Henan Chemical Co
Product
6-Methyl-2-pyridinecarboxylic acid 934-60-1
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
as request
Release date
2018-12-24

934-60-1, 6-Methyl-2-pyridinecarboxylic acidRelated Search:

Kresoxim-methyl Methanol Basic Violet 1 Acetonitrile 2-Picolinic acid Methyl acrylate 2,6-Lutidine Methylparaben Chromium picolinate Paraquat dichloride 4-Methylpyridine Zinc picolinate Methyl acetate Methyl Dimethyl 2,6-Pyridinedicarboxylate Pyrroloquinoline quinone Pyridine-2,6-dicarboxylic acid Chelidamic acid

  • 6-Methylpyridine-2-carboxylic acid 98%
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  • 6-METHYLPICOLINIC ACID 98+%
  • 6-METHYL PYRIDINE-2-CARBOXYLIC ACID HCL
  • 6-Methylpicolinic acid,97%
  • 6-Methylpyridine-2-carboxylic acid,6-Methylpicolinic acid
  • 6-Methyl-2-pyridinecarboxylic Acid, 95+%
  • IFLAB-BB F1790-0068
  • 6-METHYLPYRIDINE-2-CARBOXYLIC ACID
  • 6-METHYLPICOLINIC ACID
  • 6-METHYL-2-PYRIDINECARBOXYLIC ACID
  • 6-METHYL-2-PICOLINIC ACID
  • 6-Methylpyridine-2-carboxylicacid,95%
  • NSC 109143
  • NSC 26023
  • 2-methyl-6-pyridinecarboxylic acid
  • RARECHEM AL BO 1402
  • 2-Carboxy-6-methylpyridine
  • 2-Picoline-6-carboxylic acid
  • 6-Methylpyridin-2-carbonsure
  • 6-Methylpyridine-2-carboxylicAcid&gt
  • -2-pyridinecarboxyL
  • 6-Methyl-2-pyridinecarboxylicAci
  • 6-Methyl-2-pyridinecarboxylic acid ISO 9001：2015 REACH
  • 6-Methylpyridine-2-carboxalicacid
  • 934-60-1
  • 934-60-0
  • C7 and C8
  • Building Blocks
  • Heterocyclic Building Blocks
  • Pyridines
  • pharmacetical