(R)-ZINC-3573 ((R)-ZINC3573)

Product Name: (R)-ZINC-3573 ((R)-ZINC3573)
CAS No.: 2089389-15-9
Chemical Name: (R)-ZINC-3573 ((R)-ZINC3573)
Synonyms: ZINC3573;ZINC-3573;ZINC 3573;(R)-ZINC-3573, 10 mM in DMSO;(R)-ZINC-3573 ((R)-ZINC3573);(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine;(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine;(3R)-N,N-dimethyl-1-{5-phenylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-amine;3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-
CBNumber: CB24844415
Molecular Formula: C18H21N5
Formula Weight: 307.39
MOL File: 2089389-15-9.mol

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(R)-ZINC-3573 ((R)-ZINC3573) Property

Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 8.69±0.20(Predicted)
form: Solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

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(R)-ZINC-3573 ((R)-ZINC3573) Chemical Properties,Usage,Production

Biological Activity

(R)-ZINC-3573 is a selective agonist probe of the orphan receptor Mas-related G-protein coupled receptor member X2 (MRGPRX2), a G-protein coupled receptor (GPCR) selectively expressed in mast cells and dorsal root and trigeminal ganglia primary sensory neurons of primates. Lack of selective and potent probes has made it difficult to determine MRGPRX2 funtion. (R)-ZINC-3573 was shown to be a potent and selective agonist with an EC50 value of 760 nM for MRGPRX2 and little activity for MRGPRX1 or over 350 other GPCRs and 97 kinases tested. (R)-ZINC-3573 activates endogenous MRGPRX2 expressed in a human mast cell line and induced degranulation and calcium release. (S)-ZINC-3573 is inactive and can be used as a control.

storage

Store at +4°C

(R)-ZINC-3573 ((R)-ZINC3573) Preparation Products And Raw materials

Raw materials

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(R)-ZINC-3573 ((R)-ZINC3573) Suppliers

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2089389-15-9, (R)-ZINC-3573 ((R)-ZINC3573)Related Search:

4-(2,3-dihydro-1,4-benzodioxin-6-ylcarbonyl)-3-hydroxy-5-[4-(pentyloxy)phenyl]-1-(3-pyridinylmethyl)-1,5-dihydro-2H-pyrrol-2-one ZINC03129319 1-Pyrrolidinecarboxamide, 2-(4-methoxyphenyl)-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]- 1-(4,6-dimethylpyrimidin-2-yl)-3-[2-(trifluoromethyl)phenyl]guanidine 3,4-dihydro-1H-isoquinolin-2-yl-[3-(1H-indol-4-yl)-1,2,4-oxadiazol-5-yl]methanone 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, N-(tetrahydro-2H-pyran-4-yl)- ZINC13466751 2-(2-oxobenzo[cd]indol-1(2H)-yl)-N-[2-(trifluoromethyl)phenyl]acetamide 6-(3,4-dimethoxyphenyl)-3-(2-thienyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole 6-(3,4-dimethoxyphenyl)-3-(2-furyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole

(3R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-3-pyrrolidinamine

(R)-ZINC-3573 ((R)-ZINC3573)

ZINC 3573

ZINC3573

ZINC-3573

3-Pyrrolidinamine, N,N-dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)-, (3R)-

(R)-N,N-Dimethyl-1-(5-phenylpyrazolo[1,5-a]pyrimidin-7-yl)pyrrolidin-3-amine

(3R)-N,N-dimethyl-1-{5-phenylpyrazolo[1,5-a]pyrimidin-7-yl}pyrrolidin-3-amine

(R)-ZINC-3573, 10 mM in DMSO

2089389-15-9