Propargyl-PEG5-CH2CO2tBu
- Product Name
- Propargyl-PEG5-CH2CO2tBu
- CAS No.
- 2098489-63-3
- Chemical Name
- Propargyl-PEG5-CH2CO2tBu
- Synonyms
- Propargyl-PEG4-O-C1-Boc;Propargyl-PEG5-CH2CO2tBu;Propargyl-PEG5-CH2COOtBu;Propargyl-PEG5-CH2CO2 t-Bu Ester;Propargyl-PEG5-CH2COOH t-Bu Ester;3,6,9,12,15-Pentaoxaoctadec-17-ynoic acid, 1,1-dimethylethyl ester;tert-butyl 2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]acetate;Propargyl-PEG4-CH2COOtBu/3,6,9,12,15-Pentaoxaoctadec-17-ynoic acid, 1,1-dimethylethyl ester
- CBNumber
- CB24849647
- Molecular Formula
- C17H30O7
- Formula Weight
- 346.42
- MOL File
- 2098489-63-3.mol
Propargyl-PEG5-CH2CO2tBu Property
- Boiling point:
- 406.8±40.0 °C(Predicted)
- Density
- 1.055±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Light yellow to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23857
- Product name
- Propargyl-PEG5-CH2CO2tBu
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-23857
- Product name
- Propargyl-PEG5-CH2CO2tBu
- Purity
- 98%
- Packaging
- 250mg
- Price
- $540
- Updated
- 2021/12/16
- Product number
- BP-23857
- Product name
- Propargyl-PEG5-CH2CO2tBu
- Purity
- 98%
- Packaging
- 500mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- B-1487
- Product name
- Propargyl-PEG4-CH2COOtBu
- Purity
- 97%
- Packaging
- 1g
- Price
- $366.67
- Updated
- 2021/12/16
Propargyl-PEG5-CH2CO2tBu Chemical Properties,Usage,Production
Description
Propargyl-PEG5-CH2CO2tBu enables the formation of triazole linkages with azide compounds or biomolecules in copper catalyzed Click Chemistry reactions. The t-butyl group can be hydrolyzed under acidic conditions.
Uses
Propargyl-PEG4-O-C1-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-O-C1-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs; Alkyl/ether
References
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing ProteinDegradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781
Propargyl-PEG5-CH2CO2tBu Preparation Products And Raw materials
Raw materials
Preparation Products
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