Propargyl-PEG5-amine
- Product Name
- Propargyl-PEG5-amine
- CAS No.
- 1589522-46-2
- Chemical Name
- Propargyl-PEG5-amine
- Synonyms
- Alkyne-PEG5-NH2;HC≡C-CH2-PEG6-NH2;PROPARGYL-PEG5-NH2;Propargyl-PEG5-amine;3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;Propargyl-PEG5-NH2/3,6,9,12,15-Pentaoxaoctadec-17-yn-1-amine;2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethanamine
- CBNumber
- CB63062630
- Molecular Formula
- C13H25NO5
- Formula Weight
- 275.34
- MOL File
- 1589522-46-2.mol
Propargyl-PEG5-amine Property
- Boiling point:
- 360.4±37.0 °C(Predicted)
- Density
- 1.049±0.06 g/cm3(Predicted)
- solubility
- DMSO : 100 mg/mL (363.19 mM; Need ultrasonic)
- pka
- 8.74±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-22103
- Product name
- Propargyl-PEG5-amine
- Purity
- 98%
- Packaging
- 500mg
- Price
- $680
- Updated
- 2021/12/16
- Product number
- BIPG1726
- Product name
- Propargyl-PEG5-amine
- Packaging
- 250mg
- Price
- $759
- Updated
- 2021/12/16
- Product number
- BP-22103
- Product name
- Propargyl-PEG5-amine
- Purity
- 98%
- Packaging
- 1g
- Price
- $1020
- Updated
- 2021/12/16
- Product number
- B-1144
- Product name
- Propargyl-PEG5-NH2
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $201.66
- Updated
- 2021/12/16
- Product number
- B-1144
- Product name
- Propargyl-PEG5-NH2
- Purity
- 97%
- Packaging
- 0.5g
- Price
- $302.5
- Updated
- 2021/12/16
Propargyl-PEG5-amine Chemical Properties,Usage,Production
Description
Propargyl-PEG5-amine is a propargyl linker that is commonly used as a Click Chemistry reagent for copper-catalyzed reactions with azides. The amine moiety reacts with carboxylic acids, activated NHS esters and other carbonyl compounds. The PEG spacer helps improve the water solubility of the molecule in aqueous media.
Biological Activity
Propargyl-PEG5-amine is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Non-cleavable < span> | PEGs
|
Propargyl-PEG5-amine Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG5-amine Suppliers
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View Lastest Price from Propargyl-PEG5-amine manufacturers
- Product
- Propargyl-PEG5-amine 1589522-46-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-04-08
- Product
- Propargyl-PEG5-amine 1589522-46-2
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-26