H2N-PEG2-Propyne

Product Name: H2N-PEG2-Propyne
CAS No.: 944561-44-8
Chemical Name: H2N-PEG2-Propyne
Synonyms: Propargyl-PEG2-NH2;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine;HC≡C-CH2-PEG2-NH2;2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine hydrochloride;NH2-PEG2-Al;Alkyne-PEG2-NH2;H2N-PEG2-Propyne;Alkyne-PEG2-amine;Propyne-PEG2-amine;NH2-PEG2-Propargyl
CBNumber: CB82546863
Molecular Formula: C7H13NO2
Formula Weight: 143.18
MOL File: 944561-44-8.mol

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H2N-PEG2-Propyne Property

Boiling point:: 213.8±20.0 °C(Predicted)
Density: 0.992±0.06 g/cm3(Predicted)
refractive index: 1.4590 to 1.4630
Flash point:: 88°
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO:100.0(Max Conc. mg/mL);698.37(Max Conc. mM)
form: clear liquid
pka: 8.72±0.10(Predicted)
color: Colorless to Almost colorless
Appearance: colorless to yellow liquid

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Safety

RIDADR: UN 2735 8/PG II
HS Code: 2922.19.9690
HazardClass: 8
PackingGroup: II

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2225
Product name: 2-[2-(2-Propynyloxy)ethoxy]ethylamine
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $96
Updated: 2025/07/31

TCI Chemical

Product number: P2225
Product name: 2-[2-(2-Propynyloxy)ethoxy]ethylamine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $348
Updated: 2025/07/31

BroadPharm

Product number: BP-22519
Product name: Propargyl-PEG2-amine
Purity: 98%
Packaging: 1g
Price: $360
Updated: 2021/12/16

ChemScene

Product number: CS-0044012
Product name: Propargyl-PEG2-amine
Purity: 96.52%
Packaging: 10g
Price: $373
Updated: 2021/12/16

Ark Pharm

Product number: P000486784
Product name: 2-[2-(2-Propynyloxy)ethoxy]ethylamine
Purity: 97%
Packaging: 10g
Price: $379
Updated: 2021/12/16

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H2N-PEG2-Propyne Chemical Properties,Usage,Production

Description

Propargyl-PEG2-amine is a crosslinker that is reactive with NHS esters, carbonyls (carboxylic acid, ketone, aldehyde). The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reaction to form a stable triazole linkage.

Uses

2-[2-(2-Propynyloxy)ethoxy]ethylamine is used in preparation of RSV F protein inhibitors conjugated to Fc variants and albumins.

Synthesis

1245006-63-6

944561-44-8

The general procedure for the synthesis of 2-(2-(prop-2-yn-1-yloxy)ethoxy)ethylamine from the compound (CAS:1245006-63-6) is as follows: General method: polymer-loaded triphenylphosphine (1.15 eq.) was added to an anhydrous tetrahydrofuran (THF) solution of azide alkynes S3. Subsequently, the reaction mixture was stirred at room temperature for 48 hours. Next, deionized water (1 mL) was added to the flask and the resulting mixture was continued to be stirred at room temperature for 48 hours. Upon completion of the reaction, the mixture was filtered through a bed of diatomaceous earth to collect insoluble solids and washed with ethyl acetate (25 mL). Finally, the combined filtrates were concentrated under reduced pressure to give the target product aminoalkynes 6.

IC 50

Non-cleavable Linker; PEGs

References

[1] Molecules, 2013, vol. 18, # 9, p. 11639 - 11657
[2] Journal of the American Chemical Society, 2010, vol. 132, # 36, p. 12711 - 12716
[3] Drug Design, Development and Therapy, 2018, vol. 12, p. 987 - 995
[4] Journal of Porphyrins and Phthalocyanines, 2013, vol. 17, # 1-2, p. 104 - 117

H2N-PEG2-Propyne Preparation Products And Raw materials

Raw materials

Preparation Products

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H2N-PEG2-Propyne Suppliers

Belgium 1 Canada 1 China 122 Germany 2 India 4 Japan 3 Poland 1 Spain 1 United Kingdom 5 United States 23 Global 163

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
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Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
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Energy Chemical

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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
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Email: sales@accelachem.com
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ChemPep, Inc.

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T&W GROUP

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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
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ProdList: 39966
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View Lastest Price from H2N-PEG2-Propyne manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG2-amine 944561-44-8
Price: US $0.00/g
Min. Order: 25g
Purity: >98.00%
Supply Ability: 25g
Release date: 2024-03-26

Career Henan Chemical Co

Product: H2N-PEG2-Propyne 944561-44-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-09

944561-44-8, H2N-PEG2-PropyneRelated Search:

Azido-PEG4-NHS Ester Thiol-dPEG5-azido H2N-PEG4-Propyne H2N-PEG11-OH 20-Azido-3,6,9,12,15,18-hexaoxaeicosan-1-amine HO-PEG8-CH2CH2COOH Maleimide-PEG2-NHS Ester PEG5-acid Bis-PEG4-acid Bromoacetamido-PEG4-azido Amino-PEG12-alcohol Propargyl-PEG7-alcohol Propargyl-PEG3-amine O-(2-AMinoethyl)-O'-(2-azidoethyl)triethylene Glycol 3-(2-(2-bromoethoxy)ethoxy)prop-1-yne Cy7 Propargyl-PEG8-bromide Propargyl-PEG9-amine

H2N-PEG2-Propyne

HC≡C-CH2-PEG2-NH2

Propargyl-PEG2-NH2

Propyne-PEG2-amine

Alkyne-PEG2-NH2

2-[2-(2-Propynyloxy)ethoxy]ethylamine

Propargyl-PEG2-amine

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethanamine

2-[2-(2-Propynyloxy)ethoxy]ethylamine&gt

Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]-

Alkyne-PEG2-amine

2-[2-(Propargyloxy)ethoxy]ethylamine

2-(2-(prop-2-yn-1-yloxy)ethoxy)ethan-1-amine hydrochloride

2-(2-prop-2-ynoxyethoxy)ethanamine

2-(2-Prop-2-ynyloxy-ethoxy)-ethyla

Propargyl-PEG2-NH2/Ethanamine, 2-[2-(2-propyn-1-yloxy)ethoxy]-

NH2-PEG2-Al

NH2-PEG2-Propargyl

944561-44-8

Heterobifunctional PEG

peg