Alkyne-PEGn-NH2 2K, 5K, 10K, 20K
- Product Name
- Alkyne-PEGn-NH2 2K, 5K, 10K, 20K
- CAS No.
- 956348-61-1
- Chemical Name
- Alkyne-PEGn-NH2 2K, 5K, 10K, 20K
- Synonyms
- Propargyl-PEGn-amine;Alkyne-PEGn-NH2 2K, 5K, 10K, 20K;Poly(oxy-1,2-ethanediyl), α-(2-aminoethyl)-ω-(2-propyn-1-yloxy)-
- CBNumber
- CB32654376
- Molecular Formula
- (C2H4O)nC5H9NO
- Formula Weight
- 0
- MOL File
- 956348-61-1.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-23544
- Product name
- Propargyl-PEG24-amine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- BP-23544
- Product name
- Propargyl-PEG24-amine
- Purity
- 98%
- Packaging
- 1g
- Price
- $900
- Updated
- 2021/12/16
Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Chemical Properties,Usage,Production
Description
Propargyl-PEG12-amine is a heterobifunctional reagent that enables amide formation with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group is reactive with azide compounds via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The PEG units enhance the hydrophilicity of the molecule in aqueous media.
Uses
Propargyl-PEG-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs
References
[1] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Preparation Products And Raw materials
Raw materials
Preparation Products
Alkyne-PEGn-NH2 2K, 5K, 10K, 20K Suppliers
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