THIAMINE MONOPHOSPHATE CHLORIDE Property

Melting point:

~200°

Density 

1.53[at 20℃]

storage temp. 

2-8°C

solubility 

Methanol (Slightly), Water (Slightly)

form 

Solid

color 

White to Off-White

Water Solubility 

176g/L at 20℃

Stability:

Hygroscopic

LogP

-4.7 at 20℃

Safety

WGK Germany 

3

F 

3-10

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

THIAMINE MONOPHOSPHATE CHLORIDE Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

Vitamin B1 Monophosphate Chloride is a precursor of thiamine pyrophosphate (T344070), a thiamine (T344185) derivative produced by enzyme thiamine pyrophosphatase. Thiamine pyrophosphate is a cofactor used to catalyze various biochemical reactions.

Definition

ChEBI: Thiamine(1+) monophosphate chloride is an organic chloride salt of thiamine(1+) monophosphate. It is an organic chloride salt and a vitamin B1. It contains a thiamine(1+) monophosphate.

Flammability and Explosibility

Not classified

Purification Methods

Purify it by recrystallisation from aqueous HCl, EtOH slightly acidified with HCl, EtOH/Me2CO, H2O, or H2O/EtOH/Et2O. Dissolve it in a small volume of H2O and mix it with EtOH/Me2CO (1:1) to give the HCl.H2O as crystals. Filter it off, wash it with Et2O and dry it in a vacuum. The chloride hydrochloride, m 215-217o(dec) is obtained when it is crystallised from aqueous HCl. [Wenz et al. Justus Liebigs Ann Chem 618 2280 1958, Viscontini et al. Helv Chim Acta 34 1388 1951, Leichssenring & Schmidt Chem Ber 95 767 1962, McCormick & Wright Methods Enzymol 18A 141, 147 1970, Beilstein 27 III/IV 1766.]