3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
- Product Name
- 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
- CAS No.
- 100202-39-9
- Chemical Name
- 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE
- Synonyms
- Methyl azetidine-3-carboxylate hydrochloride;Azetidine-3-carboxylic methyl ester hrdrochloride;Methyl azetidine-3-carbox...;methyl azetidine-3-carboxylate HCl;Methyl 3-Azetidine carboxylate HCl;AZETIDINE-3-CARBOXYLIC METHYL ESTER HCL;3-AZETIDINECARBOXYLIC ACID, MEHYDROCHLORIDE;3-Azetidinecarboxylic acid methyl ester HCl;Azetidine-3-Methyl carboxylate Hydrochloride;AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER HCL
- CBNumber
- CB2494090
- Molecular Formula
- C5H10ClNO2
- Formula Weight
- 151.59
- MOL File
- 100202-39-9.mol
3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE Property
- Melting point:
- 93.0 to 97.0 °C
- Boiling point:
- 187-192℃
- Flash point:
- 69°(156°F)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- Water Solubility
- Soluble in water
- form
- powder to crystal
- color
- White to Almost white
- InChI
- InChI=1S/C5H9NO2.ClH/c1-8-5(7)4-2-6-3-4;/h4,6H,2-3H2,1H3;1H
- InChIKey
- UOCWTLBPYROHEF-UHFFFAOYSA-N
- SMILES
- C(C1CNC1)(=O)OC.Cl
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M2521
- Product name
- Methyl Azetidine-3-carboxylate Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 1g
- Price
- $31
- Updated
- 2025/07/31
- Product number
- M2521
- Product name
- Methyl Azetidine-3-carboxylate Hydrochloride
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $89
- Updated
- 2025/07/31
- Product number
- M288698
- Product name
- Methyl Azetidine-3-carboxylate Hydrochloride
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M288698
- Product name
- Methyl Azetidine-3-carboxylate Hydrochloride
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- M5857
- Product name
- Methyl Azetidine-3-carboxylate Hydrochloride
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Methyl Azetidine-3-carboxylate Hydrochloride can be used to prepare inhibitors of of human glycogen phosphorylase to treat hyperglycemia, hyperinsulinemia, hyperlipidemia, insulin resistance or tissue ischemia.
Synthesis
53871-06-0
100202-39-9
The general procedure for the synthesis of methyl azetidine-3-carboxylate hydrochloride from methyl 1 -diphenylmethylazetidine-3-carboxylate was as follows (Preparative Example 85): methyl 1 -diphenylmethylazetidine-3-carboxylate (3.57 g) was dissolved in methanol (360 ml), and ethyl acetate solution of 4N hydrochloric acid (12.7 ml) was added, and the reaction system was maintained at 20 °C. Subsequently, palladium hydroxide (3.57 g) was added as a catalyst and the reaction was stirred at room temperature and under pressurized hydrogen atmosphere (0.4 MPa) for 11 hours. After completion of the reaction, the catalyst was removed by filtration and washed with methanol and water. The filtrate was concentrated to give the crude product of methyl azetidine-3-carboxylate hydrochloride, which presented as a light yellow oil. The reaction was assessed to be quantitative and 1.93 g of product was obtained, which can be used directly in subsequent reactions. The product was detected by ESI-MS, m/z: 116 [M + H]+.
IC 50
Non-cleavable Linker
References
[1] Patent: EP1889836, 2008, A1. Location in patent: Page/Page column 80
[2] Patent: US2008/214815, 2008, A1. Location in patent: Page/Page column 14-15
3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE manufacturers
- Product
- 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE 100202-39-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-11-28
- Product
- 3-AZETIDINECARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE 100202-39-9
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23